Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 342617-08-7, name is 3-(3-Bromophenyl)-4H-1,2,4-triazole, A new synthetic method of this compound is introduced below., category: Triazoles
EXAMPLE 11 A mixture of 2.67 g of oxamohydrazide, 4.05 g of formamidine acetate and 30 ml of formamide was heated for reaction at 72 to 74 C. for 1.5 hours. After reaction, the resulting reaction mixture was cooled to room temperature and then filtered. The thus obtained crystal was washed with 10 ml of 2-propanol and then added to a mixture of 20 ml of conc. aqueous ammonia and 80 ml of water. The resulting reaction mixture was stirred at room temperature for 10 minutes and then filtered to obtain 0.22 g of oxamide as a crystal. The filtrate was concentrated under reduced pressure to obtain 2.01 g (69%) of 1,2,4-triazole-3-carboxamide as a crystal.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Ube Industries, Ltd.; US4578479; (1986); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics