Application of 4-(1,2,4-Triazol-1-yl)aniline

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6523-49-5 as follows. Safety of 4-(1,2,4-Triazol-1-yl)aniline

Step 1 intermediate (310 mg) was treated with DMF-DMA (5 ml) in DMF(3 ml) at 80 for 3 h. The mixture was evaporated, dissolved in toluene and concentrated to a pale yellow solid which was dried overnight. A portion of this material (74 mg) was treated with 4-triazolylaniline (57 mg) in AcOH (1 ml) at 80 for 2 h. The cooled mixture was basified with aq sodium bicarbonate and the resulting precipitate filtered, washed with water, ether and MeCN to give the title compound (88 mg, 59 %). 1H NMR delta 10.5 (IH, brs), 9.26 (IH5 s), 8.87 (IH5 s), 8.59 (3H5 m), 8.23 (IH5 s), 8.1 (3H5 m), 7.84 (5H, m) 7.47 (5H, m), 7.18 (2H, m), 5.29 (2H5 s); LC-MS rt 2.23 m/z472 ES+.

According to the analysis of related databases, 6523-49-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ARROW THERAPEUTICS LIMITED; WO2007/80401; (2007); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics