Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7170-01-6, name is 3-Methyl-1H-1,2,4-triazole, A new synthetic method of this compound is introduced below., Safety of 3-Methyl-1H-1,2,4-triazole
Example 23a 5-(3-Methyl-1H-1,2,4-triazol-1-yl)pyridin-2-amine CuI (285 mg, 20 mol %), L-proline (345 mg, 40 mol %) and potassium carbonate3 (2.07 g, 15.00 mmol) were added to a solution of 5-bromo-pyridin-2-ylamine (CAS 1072-97-5, 1.30 g, 7.50 mmol) and 3-methyl-1H-[1,2,4]triazole (CAS 7170-01-6, 935 mg, 11.3 mmol) in anhydrous DMSO (5 mL). The reaction mixture was heated at 120 C. for 5 days, cooled to r.t., diluted with DCM and filtered through a pad of Celite. The filtrate was concentrated under reduced pressure and the residue was purified by a reversed phase purification (C18-column) using stepped gradients of 20 to 50% MeOH in water (containing 1% NH4OH) to give the title product (153 mg, 12%). 1H NMR (400 MHz, MeOD) delta ppm 2.41 (s, 3H) 6.67 (d, 1H) 7.75 (dd, 1H) 8.24 (d, 1H) 8.72 (s, 1H). MS (ES) m/z 176.2 [M+H]+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ASTRAZENECA AB; US2012/122843; (2012); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics