The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 6-Methylnicotinic acid(SMILESS: O=C(O)C1=CN=C(C)C=C1,cas:3222-47-7) is researched.Safety of 2,4-Dimethyl-1H-pyrrole. The article 《Catalytic deoxygenative coupling of aromatic esters with organo-phosphorus compounds》 in relation to this compound, is published in ChemRxiv. Let’s take a look at the latest research on this compound (cas:3222-47-7).
We have developed a deoxygenative coupling of aromatic esters with diarylphosphine oxides/dialkyl phosphonates under palladium catalysis. Reaction of Ph aromatic esters ArCO2Ph with hydrophosphoryl compounds HP(O)R2 (R = Ph, aryl, BuO) in the presence of PdCl2/dcype and HCO2Na reductant afforded benzyl phosphine oxides, phosphonates and phosphinates ArCH2P(O)R2. In this reaction, aromatic esters can work as novel benzylation reagents to give the corresponding benzylic phosphorus compounds The key of this reaction is the use of Ph esters, an electron-rich diphosphine as a ligand, and sodium formate as a hydrogen source. Arylcarboxylic acids were also applicable in this reaction using (Boc)2O as an additive. Palladium/dcype worked as a bifunctional catalyst to activate the acyl C-O bond of the ester and to support the reduction with sodium formate.
Different reactions of this compound(6-Methylnicotinic acid)Name: 6-Methylnicotinic acid require different conditions, so the reaction conditions are very important.
Reference:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics