Authors Abd El-Aleam, RH; George, RF; Hassan, GS; Abdel-Rahman, HM in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about CATALYTIC INHIBITORS; DISCOVERY; DESIGN in [Abd El-Aleam, Rehab H.] Modern Univ Technol & Informat MTI, Fac Pharm, Pharmaceut Chem Dept, Cairo 11571, Egypt; [George, Riham F.; Hassan, Ghaneya S.] Cairo Univ, Fac Pharm, Pharmaceut Chem Dept, Cairo 11562, Egypt; [Hassan, Ghaneya S.] Badr Univ, Fac Pharm, Pharmaceut Chem Dept, Cairo 11829, Egypt; [Abdel-Rahman, Hamdy M.] Assiut Univ, Fac Pharm, Med Chem Dept, Assiut 71526, Egypt; [Abdel-Rahman, Hamdy M.] Nahda Univ, Fac Pharm, Pharmaceut Chem Dept, Bani Suwayf, Egypt in 2020.0, Cited 20.0. HPLC of Formula: C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5
A series of 1,2,4-triazolo [1,5-a]pyrimidine derivatives was designed, synthesized and screened for their antibacterial and antifungal activities as well as their safety profile. Compounds 2b, 3a, 6b, 8b, 8c, 8h, 9a,b, 10b, 11a,b and 12a,b showed high activity against Gram-positive and Gram-negative bacteria with MIC values ranging from 0.25 to 2.0 mu g/mL. Many compounds were safe with no cytotoxicity against human embryonic kidney and red blood cells at concentration up to 32 mu g/mL. Moreover, compound 9a showed the highest inhibitory activity against DNA Gyrase with IC50 = 0.68 mu M compared to ciprofloxacin IC50 = 0.85 mu M. Molecular docking at DNA Gyrase active site revealed binding mode and docking scores comparable to that of ciprofloxacin confirming their antibacterial activity via DNA Gyrase inhibition.
About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Abd El-Aleam, RH; George, RF; Hassan, GS; Abdel-Rahman, HM or concate me.. HPLC of Formula: C2H4N4
Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics