Nagarkoti, S; Dubey, M; Sadaf, S; Awasthi, D; Chandra, T; Jagavelu, K; Kumar, S; Dikshit, M in [Nagarkoti, Sheela; Dubey, Megha; Sadaf, Samreen; Awasthi, Deepika; Jagavelu, Kumaravelu; Kumar, Sachin] Cent Drug Res Inst, CSIR, Pharmacol Div, Lucknow, Uttar Pradesh, India; [Chandra, Tulika] King Georges Med Univ, Lucknow, Uttar Pradesh, India; [Dikshit, Madhu] Translat Hlth Sci & Technol Inst, NCR Biotech Sci Cluster, THSTI Natl Chair, 3rd Milestone,Faridabad Gurgaon Expressway, Faridabad 121001, Haryana, India published Catalase S-Glutathionylation by NOX2 and Mitochondrial-Derived ROS Adversely Affects Mice and Human Neutrophil Survival in 2019.0, Cited 70.0. SDS of cas: 61-82-5. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.
Neutrophil survival and oxidative stress during inflammatory conditions are linked to tissue damage. The present study explores less understood role of catalase, the enzyme catalysing hydrogen peroxide decomposition, in neutrophil survival/death. Importantly, inhibition of catalase activity following S-glutathionylation in the PMA, NO, or zymosan-activated neutrophils or treatment with catalase inhibitor led to neutrophil death. On the contrary, introducing reducing environment by TCEP rescued catalase activity and significantly improved neutrophil survival. Furthermore, augmentation in ROS generation by NOX-2 activation or induction of mitochondrial ROS by Antimycin-A induced catalase S-glutathionylation and cell death, which was prevented in the neutrophil cytosolic factor1 (NCF-1-/-) cells or was rescued by MitoTEMPO, a mitochondrial ROS scavenger, thus, suggesting a correlation between catalase S-glutathionylation/activity inhibition and reduced neutrophil survival. Altogether, enhanced NOX2 activation/mitochondrial dysfunction led to reduced survival of human and mice neutrophils, due to H2O2 accumulation, S-glutathionylation of catalase, and reduction in its enzymatic activity. The present study thus demonstrated mitigation of catalase activity under oxidative stress-impacted neutrophil survival.
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Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
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