Computed Properties of C2H4N4. Landin, EJB; Lovera, S; de Fabritiis, G; Kelm, S; Mercier, J; McMillan, D; Sessions, RB; Taylor, RJ; Sands, ZA; Joedicke, L; Crump, MP in [Landin, Erik J. B.; Crump, Matthew P.] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England; [Kelm, Sebastian; McMillan, David; Taylor, Richard J.; Joedicke, Lisa] UCB Celltech, 216 Bath Rd, Slough SL1 3WE, Berks, England; [Lovera, Silvia; Mercier, Joel; Sands, Zara A.] UCB Biopharma, 1 Chemin Foriest, B-1420 Braine Lalleud, Belgium; [de Fabritiis, Gianni] Acellera, Barcelona Biomed Res Pk PRBB,C Doctor Aiguader 88, Barcelona 08003, Spain; [de Fabritiis, Gianni] Passeig Lluis Co 23, ICREA, Barcelona 08010, Spain; [Sessions, Richard B.] Univ Bristol, Biomed Sci, Bristol BS8 1TD, Avon, England published The Aminotriazole Antagonist Cmpd-1 Stabilises a Distinct Inactive State of the Adenosine 2A Receptor in 2019.0, Cited 25.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.
The widely expressed G-protein coupled receptors (GPCRs) are versatile signal transducer proteins that are attractive drug targets but structurally challenging to study. GPCRs undergo a number of conformational rearrangements when transitioning from the inactive to the active state but have so far been believed to adopt a fairly conserved inactive conformation. Using (FNMR)-F-19 spectroscopy and advanced molecular dynamics simulations we describe a novel inactive state of the adenosine 2A receptor which is stabilised by the aminotriazole antagonist Cmpd-1. We demonstrate that the ligand stabilises a unique conformation of helix V and present data on the putative binding mode of the compound involving contacts to the transmembrane bundle as well as the extracellular loop 2.
Welcome to talk about 61-82-5, If you have any questions, you can contact Landin, EJB; Lovera, S; de Fabritiis, G; Kelm, S; Mercier, J; McMillan, D; Sessions, RB; Taylor, RJ; Sands, ZA; Joedicke, L; Crump, MP or send Email.. Computed Properties of C2H4N4
Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics