On January 25, 2017, Bhagat, Ujjawal Kumar; Kamaluddin; Peddinti, Rama Krishna published an article.Application In Synthesis of 4-(p-Tolyl)-1H-1,2,3-triazole The title of the article was DABCO-mediated aza-Michael addition of 4-aryl-1H-1,2,3-triazoles to cycloalkenones. Regioselective synthesis of disubstituted 1,2,3-triazoles. And the article contained the following:
Aza-Michael addition of 4-aryl-1H-1,2,3-triazoles to 2-cycloalken-1-ones was studied in the presence of DABCO as organic base. The reactions were carried out in acetonitrile at room temperature to provide 2,4-disubstituted 2H-1,2,3-triazoles I [R = H, Me; Ar = C6H5, 4-MeC6H4, 2-MeO-1-naphthyl, etc.; n = 1] as major adducts and 1,4-disubstituted 1H-1,2,3-triazoles II [n = 0] as minor adducts. Though the reaction times are longer (4-8 days), the two regioisomers were separated by using column chromatog. and the adducts were obtained in very good to excellent combined chem. yields. The electron-rich and electron-poor substituents on aryl moiety of 4-aryl-triazoles could tolerate the reaction conditions to afford the title adducts. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Application In Synthesis of 4-(p-Tolyl)-1H-1,2,3-triazole
The Article related to disubstituted triazole regioselective preparation, aryl triazole cycloalkenone aza michael addition dabco mediated, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application In Synthesis of 4-(p-Tolyl)-1H-1,2,3-triazole
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics