Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 2-(2H-1,2,3-Triazol-2-yl)benzoic acid
Step iii) ir 3s-N-{4-[(6-FIuoro-l,3-benzot azol-2-yl)ammo]oxolaii-3-yI}-2-(2H-l,2,3- triazoI-2-y)beiizamide A solution of tran5-3-N-(6-fluoro-l,3-benzothiazol-2-yl)oxolane-3,4-diarriinehydrochloride (106 mg, 0.366 mmol), 2-(2H-l ,2,3-triazol-2-yl)benzoic acid (CAS number 1001401-62-2; 83 mg, 0.439 mmol), EDC (105 mg, 0.549 mmol), aza-HOBt (85 mg, 0.549 mmol ) and triethylamime (0.153 ml, 1 .097 mmol) in DCM (2 ml) was stirred at room temperature for 18 hours. The reaction mixture was diluted with DCM (20 ml) and washed with HC1 (aq., IM, 20 ml) and saturated sodium bicarbonate solution (20 ml). The organics were filtered through a hydrophobic frit and solvent evaporated in vacuo. This was then purified by reverse phase preparative HPLC (acetonitrile / water with 0.1% ammonia) to afford the title compound.1H NMR (400 MHz, CD2C12-d2) : delta ppm 3.58 – 3.95 (m, 2 H), 4.13 – 4.32 (m, 2 H), 4.32 – 4.51 (m, 2 H), 6.77 (br. s., 1 H), 6.96 – 7.11 (m, 1 H), 7.25 – 7.41 (m, 2 H), 7.43 – 7.53 (m, 1 H), 7.56 – 7.65 (m, 2 H), 7.76 (s, 2 H), 7.81 – 7.87 (m, 1 H)MS ES+: 425
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1001401-62-2.
Reference:
Patent; TAKEDA CAMBRIDGE LIMITED; TAKEDA PHARMACEUTICAL COMPANY LIMITED; FIELDHOUSE, Charlotte; GLEN, Angela; ROBINSON, John Stephen; FUJIMOTO, Tatsuhiko; WO2015/55994; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics