1186050-58-7, name is 2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid, belongs to Triazoles compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: Triazoles
A solution of 1 , 1 -dimethyl-4-(((3i?,6i?)-6-methylpiperidin-3-yl)oxy)furo[3.4- c]pyridin-3(lH)-one hydrogen chloride (0.050 g, 0.16 mmol), 2-fluoro-6-(2H)-l,2,3-triazol-2-yl) benzoic acid (0.036 g, 0.18 mmol), benzotriazole-l-yl-oxy-tris-(dimethylamino)-phosphonium hexaflurophosphate (Bop, 0.092 g, 0.21 mmol), and triethylamine (0.067 mL, 0.48 mmol) in DMF (1 mL) was stirred at RT overnight. The reaction was concentrated in vacuo and azeotroped 3x with toluene. The residue was purified by silica gel gradient chromatography (0-80% ethyl acetate in hexanes), providing the titled compound. HRMS m z (M+H) 466.1890 found, 466.1887 required.
The synthetic route of 1186050-58-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; SKUDLAREK, Jason, W.; WO2015/95442; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics