In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 22300-52-3 as follows. Safety of 4,5-Dibromo-2H-1,2,3-triazole
Step 1 : A mixture of A-24.1 (2.00 g, 1 1 .0 mmol), A-24.2 (3.80 g, 17.0 mmol), Cul (0.13 g, 0.68 mmol), A-24.3 (0.14 mL, 1 .00 mmol) and K2C03 (2.30 g, 17.0 mmol) in dry DMF (10 mL) is heated to 120¡ãC by microwave irradiation and stirred for 40 min. The mixture is poured into water and extracted with Et20. The aq. phase is acidified with HCI (4N aq. solution) and extracted with EA. The combined organic phases are dried and concentrated to give the crude product which is purified by flash column chromatography on silica gel (using a solvent gradient from 100percent EA to EA/MeOH = 9/1 ) to provide 3.6 g of A-24.4. APCI+/-: 365 [M+H]+; HPLC (Rt): 1 .10 min (Method N).
According to the analysis of related databases, 22300-52-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; RIETHER, Doris; FERRARA, Marco; HEINE, Niklas; LESSEL, Uta; NICHOLSON, Janet Rachel; PEKCEC, Anton; (102 pag.)WO2017/178344; (2017); A1;,
1,2,3-Triazole – Wikipedia,
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