Adding a certain compound to certain chemical reactions, such as: 288-88-0, name is 1H-1,2,4-Triazole, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 288-88-0, Safety of 1H-1,2,4-Triazole
To a stirred solution of 4-fluro benzaldehyde (1.0 g, 0.8 mmol) in dry DMF (5 mL), 1 H-1 ,2,4-triazole (660 mg, 0.9 mmol) and K2CO3 (2.2 g, 1.6 mmol) were added at RT and the resulting mixture was stirred overnight at 1 10 C. After completion of reaction, ice water (2 mL) was added and the mixture was extracted with EtOAc (2 x 20 ml_). The combined organic layer was washed with brine (2 ml_), dried over Na2S04 and concentrated under vacuum. The resulting product was used in next step without further purification. Yield: 46% (610 mg, white solid). LCMS: (Method A) 174.1 (M+H), Rt.1.27 min, 67.51 % (Max).
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Reference:
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; WISHART, Grant; KULKARNI, Santosh S.; RAKESH, Paul; (338 pag.)WO2020/39027; (2020); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics