Synthetic Route of 288-88-0, New Advances in Chemical Research in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 288-88-0, name is 1H-1,2,4-Triazole, molecular formula is C2H3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
Into a clean 1000ml four-necked flask 200g of 2- (4-chlorophenethyl) -2-t-butyl ethylene oxide,200g triazole,90 g PEG-7000, 38 g KOH and 0.6 g 18-crown-6,To the dropping funnel, 400 g of 2- (4-chlorophenethyl) -2-t-butyl-oxirane were added dropwise.Turn on stirringWhen heated to 108 C,Begin with the dropwise addition of 2- (4-chlorophenethyl) -2-t-butyl-oxirane,Control the reaction flask temperature does not exceed 112 ,Dropping 2h, after the addition was completed,The reaction flask temperature was controlled at 108 ~ 112 ,Insulation 5h;Then warmed to 125 ~ 128 ,Insulation 8h, sample testing,Raw material peak is less than 0.5%4-H isomer 0.3%To the reaction flask was added enough water and methylcyclohexane,Wherein the mass ratio of water and methylcyclohexane is 1: 3.5;After stratification, the water cooled crystallization of PEG,Suction filtered solid PEG recovery applied;The organic layer was cooled to crystallize tebuconazole, filtered with suction,Filter cake was washed to pH 7 to 8,The filter cake was dried to give 772 g of 1H-tebuconazole.
Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.In my other articles, you can also check out more blogs about 1H-1,2,4-Triazole.
Reference:
Patent; Jiangsu Jianpai Agrochemical Co., Ltd.; Liu Zhiyong; Zhu Peng; Yao Xuelin; Li Ming; (9 pag.)CN107176929; (2017); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics