Some common heterocyclic compound, 41253-21-8, name is Sodium 1,2,4-triazol-1-ide, molecular formula is C2H2N3Na, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: Sodium 1,2,4-triazol-1-ide
Production Example 3Synthesis of 5-(4-chlorobenzyl)-2-meth- oxymethoxymethyl-2-methyl- 1 -(1H- 1 ,2,4-triazole- 1-ylmethyl)cyclopentanol (Compound (4)): 10182] 1H-i,2,4-triazolesodium salt (13.1 mmol) was dissolved in NMP (7 ml), and then heated to an internal temperature of 115 C. To this, Compound (6) (8.76 mmol) was added, and the mixture was thoroughly washed with NMP (1.8 ml). After the internal temperature was returned to 115 C., sodium t-butoxide (5.26 mmol) and trimethyl sulfoxonium bromide (1.476 mmol) were gradually added to the mixture over a period of 3 hours. After the addition, the resulting mixture was stirred at a temperature of 115 C. for 75 minutes. After the reaction solution was cooled down to35 C., water was added to the reaction solution, and then extraction with ethyl acetate was performed. An organic layer of the extract was washed with water and saturated brine, and then dried with anhydrous sodium sulfate. The solvent was distilled off, followed by purification of the residue by silica gel column chromatography, and thus Compound (4), which was a mixture of isomers, was obtained.10183] Yield: 71%
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 41253-21-8, its application will become more common.
Reference:
Patent; KUREHA CORPORATION; Miyake, Taiji; Araki, Nobuyuki; Yamazaki, Toru; US2014/94362; (2014); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics