Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 584-13-4, name is 4H-1,2,4-Triazol-4-amine, A new synthetic method of this compound is introduced below., Application In Synthesis of 4H-1,2,4-Triazol-4-amine
5-(4H-l,2,4-TriazoI”4’ylamino)biphenyl-2-carbonitrile (CAB06022)To a solution of 4-amino-4JY-l ,2,4-triazole (3.29 g, 39.14 mmol) in DMSO (40 mL) was added KOtBu (4.39 g, 39, 14 mmol). The mixture was stirred for 0.5 hours at room temperature before CABTheta6020 (3.86 g, 19.57 mmol) was added and stirring was continued for 1 hour. The mixture was poured into crushed ice and neutralised with 2MKHSO4-solution, The white precipitate was filtered off, washed with water and iecrystalised from 2-propanol to give CAB06022 (3.62 g, 71%) as light yellow crystals. Mp. 181-182 0C; 1H NMR (400 MHz5 OMSO-d6) delta 6,51 (d, J = 2.5 Hz, IH), 6,60 (dd, J = 8.5, 2.5 Hz, IH), 7.42-7,58 (m, 5H), 7,81 (d, J = 8.5 Hz, IH), 8.89 (s, 2H), 10.34 (s, IH); 13C NMR (100,6 MHz, DMSO^) delta 101.3, 111.4, 1 12.6, 119.0, 128.4, 128.8, 128.9, 135.7, 137.8, 144.1, 146,4, 150.9; LRMS (ES+): m/z 262.0 (100%, [M+H]+); HRMS (ES+) calcd for Ci5HnN5 [M+Hf: 262,1087, found 262.1080.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; STERIX LIMITED; WOO, Lok Wai Lawrence; BUBERT, Christian; WOOD, Paul Michael; PUTEY, Aurelien; PUROHIT, Atul; POTTER, Barry Victor Lloyd; WO2011/23989; (2011); A1;,
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