Application of 584-13-4,Some common heterocyclic compound, 584-13-4, name is 4H-1,2,4-Triazol-4-amine, molecular formula is C2H4N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example – 2 4-Amino-1-[3,5-bis-(1-cyano-1-methylethyl)benzyl]-1H-[1,2,4]triazolium bromide (8) (Q. A.-Salt); Isopropanol (1.5 L), 3,5-bis-(1-cyano-1-methylethyl)benzylbromide (2) (100 g) and 4-amino-1,2,4-triazole (22.5 g) were charged in a flask at room temperature. The reaction mass was heated at 80 – 85 C for next 5 hours. The reaction mass was further cooled down to room temperature and stirred for next one hour at 25 – 35 C. The precipitated solid QA-salt was filtered and washed with fresh isopropanol (100 mL x 2). The Q.A.-salt was dried at 60 – 70 C till LOD is less than 1.0 %, giving solid product (74.4 g). m.p.: 198 – 200 C.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4H-1,2,4-Triazol-4-amine, its application will become more common.
Reference:
Patent; Cadila Healthcare Limited; EP2397472; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics