Related Products of 6523-49-5, New Advances in Chemical Research in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 6523-49-5, name is 4-(1,2,4-Triazol-1-yl)aniline, molecular formula is C8H8N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
A solution of Intermediate 11 (96mg, 0.23mmol, leq), and 4-(7No.-l,2,4-triazol-l- yl)aniline (38mg, 0.24mmol, 1.05mmol) in acetic acid (2mL) was heated at reflux. After Ih the reaction was allowed to cool to room temperature, concentrated in vacuo and treated with a saturated aqueous solution OfK2CO3 until effervescence ceased. The resulting mixture was then concentrated in vacuo to dryness to yield a brown residue. The residue was purified using flash column chromatography, eluting initially with 200:8:1 and then 100:8:1 CH2Cl2 :EtOH:NH3. The title compound was isolated as an off-white solid (48mg, 40%). Rf = 0.39 (40:8:1 CH2Cl2:Et0H:NH3). 1H-NMR (DMSCwZ6) 2.11 (s, 6H), 2.17 (s, 3H), 2.43 (m, 2H), 2.68 (t, 2H), 4.08 (t, 2H), 7.23 (m, IH), 7.56 (m, IH), 7.75 (m, 3H), 7.93 (m, 2H), 8.08 (m, 2H), 8.50 (s, IH), 8.68 (s, IH), 9.14 (s, IH), 9.92 (br. s, IH). LC-MS rt 2.08 m/z 527 ES+
Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.In my other articles, you can also check out more blogs about 4-(1,2,4-Triazol-1-yl)aniline.
Reference:
Patent; ARROW THERAPEUTICS LIMITED; WO2007/80401; (2007); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics