In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7170-01-6 as follows. category: Triazoles
A mixture of 1.66 g (20 mmol) of 3-methyl-1,2,4-triazole and 16.6 ml of tetrahydrofuran was added dropwise, and 2.29 g (10 mmol) of pure 2-bromoisobutyryl bromide was added dropwise over 30 minutes, The mixture was further stirred for 2 hours, filtered and the insoluble material was filtered off and the filtrate was concentrated to dryness under reduced pressure. 5 ml of methyl tert-butyl ether was added, stirred for 30 minutes, filtered, and the cake was dried to obtain 2.09g of product, yield 90%.
According to the analysis of related databases, 7170-01-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Ningbo Baisijia Pharmaceutical Technology Co., Ltd.; Jin Chunhua; Tang Jianbo; Wang Kedi; Zhu Qinfeng; (13 pag.)CN106866558; (2017); A;,
1,2,3-Triazole – Wikipedia,
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