Adding a certain compound to certain chemical reactions, such as: 7170-01-6, name is 3-Methyl-1H-1,2,4-triazole, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7170-01-6, Quality Control of 3-Methyl-1H-1,2,4-triazole
A suspension of 6-bromo-7-(dimethoxymethyl)-I ,2,3,4-tetrahydro-I ,8-naphthyridine (intermediate12) (300 mg, 1.045 mmol), 3-methyl-I H-I ,2,4-triazole (104 mg, 1.254 mmol), Cs2CO3 (720 mg,2.210 mmol) and Cul (40 mg, 0.210 mmol) in DMF (2 ml) was heated to 120 C for approximately 6 h. The reaction mixture was diluted with ethyl acetate and water, layers were separated and the aqueous layer was extracted with ethyl acetate (3x). Organic layers were combined, washed with water and brine, dried using Na2SO4, filtered, evaporated. The crude product was purified by silica gel column chromatography eluting with a gradient of MeOH (1-10%) in DCM. Product fractionswere combined, evaporated and dried to yield the title compound as an orange resin. (UPLC-MS 3)tR 0.57 mm; ESI-MS 290.1 [M+H]+. 1H NMR (400 MHz, CDCI3) 5 8.21 (s, I H), 7.21 (s, I H), 5.35 (s, I H), 4.95 (s, I H), 3.51 – 3.41 (m, 2H), 3.36 (s, 6H), 2.75 (t, 2H), 2.47 (s, 3H), 1.97 – 1.86 (m, 2H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Methyl-1H-1,2,4-triazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NOVARTIS AG; BUSCHMANN, Nicole; FAIRHURST, Robin Alec; FURET, Pascal; KNOePFEL, Thomas; LEBLANC, Catherine; MAH, Robert; NIMSGERN, Pierre; RIPOCHE, Sebastien; LIAO, Lv; XIONG, Jing; ZHAO, Xianglin; HAN, Bo; WANG, Can; WO2015/59668; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics