Brief introduction of 7170-01-6

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Methyl-1H-1,2,4-triazole, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 7170-01-6, name is 3-Methyl-1H-1,2,4-triazole, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7170-01-6, Formula: C3H5N3

2-fluoro-5-nitrobenzontre (237 g, 14.3 mrno), 3-methy1 H-I ,2,4-trazoe (1.18 g, 14.3 mrno) and K2C03 (3.94 g, 28.5 mmo) n DMF (20 mD were stirred at RT for 18h, The reacUon mxture was quenched wth water and extracted with AcOEt, The organic phase was dried over Na2SO4, fHtered and concentrated. The residue was purfled by preparative HPLC (Method A4) to afford 2-(3-methy[-1 H-I ,2,4-triazo-1-y)-5- ntrobenzontre. M/z = 230 [M+H]+, Rt = 0.69 rnn (UPLC Method B5).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Methyl-1H-1,2,4-triazole, and friends who are interested can also refer to it.

Reference:
Patent; NOVARTIS AG; PISSOT SOLDERMANN, Carole; QUANCARD, Jean; SCHLAPBACH, Achim; SIMIC, Oliver; TINTELNOT-BLOMLEY, Marina; ZOLLER, Thomas; (161 pag.)WO2015/181747; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics