Synthetic Route of 7411-23-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7411-23-6 as follows.
3,5-Dibromo-1,2,4-triazole (1; 1.134 g, 5.0 mmol) and 4-chloro-2,6-bis(hydroxymethyl)phenol (2q; 472 mg, 2.5 mmol) were refluxed for5 h in DMF (10 mL). After completion of the reaction, the mixture wascooled and poured into H2O (30 mL). The precipitate formed was collectedby filtration, washed with H2O, dried, and recrystallized; yield:722 mg (55%); colorless crystals; mp 258-260 C (DMF).IR (KBr): 2924, 1601, 1555, 1520, 1470, 1431, 1292, 1261, 1180, 1150,1065, 987, 864 cm-1.1H NMR (400 MHz, DMSO-d6): delta = 7.58 (d, J = 2.3 Hz 1 H, Ar), 7.50 (d,J = 2.3 Hz, 1 H, Ar), 5.47 (s, 2 H, CH2), 5.29 (s, 2 H, CH2).13C NMR (100 MHz, DMSO-d6): delta = 153.2 (C), 145.0 (C), 140.3 (C),137.2 (C), 132.2 (C), 130.6 (CH), 129.2 (C), 128.4 (CH), 124.9 (C), 119.0(C), 48.0 (CH2), 46.1 (CH2).MS for 79Br, 35Cl (EI): m/z (%) = 522 (2, [M]+), 443 (2, [M – Br]+), 364 (1,[M – 2 Br]+), 298 (7, [M – C2Br2N3]+), 218 (5), 177 (5), 156 (21), 153(23, [C8H6ClO]+), 137 (20), 128 (30), 125 (58), 102 (73), 89 (100), 80(65).Anal. Calcd for C12H6Br3ClN6O: C, 27.43; H, 1.15; N, 16.00. Found: C,27.51; H, 1.09; N, 16.09.
According to the analysis of related databases, 7411-23-6, the application of this compound in the production field has become more and more popular.
Reference:
Article; Osipov, Dmitry V.; Osyanin, Vitaly A.; Voskressensky, Leonid G.; Klimochkin, Yuri N.; Synthesis; vol. 49; 10; (2017); p. 2286 – 2296;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics