Synthetic Route of 74205-82-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 74205-82-6, name is (1H-1,2,4-Triazol-1-yl)methanol belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below.
Step 2–Preparation of 1-(chloromethyl)-1,2,4-triazole hydrochloride A 4 neck 1 liter flask equipped with condenser, addition funnel and mechanical stirrer was charged 45 gms of 1-(hydroxymethyl)-1,2,4-triazole (0.464 mole) in 500 ml of THF was heating to 40 C. with vigorous stirring. Then SOCl2 (61 ml, 0.84 mole) was added dropwise maintaining the temperature at 45 C. During the addition, a precipitate formed and the mixture was stirred for an additional 2 hours. The product was filtered, washed three times with ethyl acetate and vacuum dried at room temperature. 67.3 gms of product having a melting point of 118-130 C. resulted (94.2% yield).
The synthetic route of (1H-1,2,4-Triazol-1-yl)methanol has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Rohm and Haas Company; US5087635; (1992); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics