Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone, is researched, Molecular C10H7F2N3O, CAS is 86404-63-9, about Development & validation of stability indicating UPLC method for quantitative estimation of voriconazole and its impurities in drug substance.Formula: C10H7F2N3O.
Simple and sensitive RP-UPLC method for the separation and quantification of voriconazole and its impurities are described. Samples are analyzed by means of reverse phase (RP-UPLC) using an Acquity UPLC BEH Shield RP18 (2.1mm x 100mm, 1.7μ), and the mobile phase consists of two Channels A and B. Channel-A 0.05% TFA in water and Channel-B: 0.05% TFA in methanol. The flow rate is 0.2 mL/min. The column temperature was maintained at 30°C and sample temperature was maintained at ambient and wavelength fixed at 255nm UVdetection. It is found that the method of RP-UPLC with UV-detection system for the anal. of voriconazole impurities are straight forward and applied in qual. and quant. anal. The developed UPLC method was validated with respect to specificity, precision, linearity, ruggedness and robustness. Validation study compared as per ICH guideline.
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Reference:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics