So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zou, Yan; Zhao, Qingjie; Liao, Jun; Hu, Honggang; Yu, Shichong; Chai, Xiaoyun; Xu, Mingjuan; Wu, Qiuye researched the compound: 1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone( cas:86404-63-9 ).SDS of cas: 86404-63-9.They published the article 《New triazole derivatives as antifungal agents: Synthesis via click reaction, in vitro evaluation and molecular docking studies》 about this compound( cas:86404-63-9 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: triazolylpropanol difluorophenyl fluconazole derivative preparation antifungal. We’ll tell you more about this compound (cas:86404-63-9).
A series of 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-substituted-2-propanols, which are analogs of fluconazole, have been designed and synthesized via Cu(I)-catalyzed azide-alkyne cycloaddition on the basis of computational docking experiments to the active site of the cytochrome P 450 14α-demethylase (CYP51). The in vitro antifungal activities of all the target compounds were evaluated against eight human pathogenic fungi. 4-Methylbenzyl-substituted compound I showed the best antifungal activities.
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Reference:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics