In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 15294-81-2 as follows. Recommanded Product: 4,5-Dibromo-1H-1,2,3-triazole
A mixture of A-6.1 (2.00 g, 11.0 mmol), A-6.2 (3.88 g, 17.1 mmol), Cul (0.13 g, 0.68 mmol), A-6.3 (0.15 mL, 1.03 mmol) and K2003 (2.36 g, 17.1 mmol) in dry DMF (10 mL) isheated to 12000 by microwave for 40 mm. The mixture is poured into water and extracted with Et20. The aq. phase is acidified with HCI (4M aq. solution) and extracted with EA. The combined organic phases are dried and concentrated to give the crude product which is purified by flash column chromatography on silica gel (using a solvent gradient from 100percent EA to EAIMeOH = 9/1) to provide 3.6 g of A-6.4. APCI+/-: 365 [M+H] HPLC (Rt): 1.10 mm (methodG).
According to the analysis of related databases, 15294-81-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; RIETHER, Doris; FERRARA, Marco; HEINE, Niklas; LESSEL, Uta, Friederike; LIPINSKI, Radoslaw; SCHEUERER, Stefan; (50 pag.)WO2019/25275; (2019); A1;,
1,2,3-Triazole – Wikipedia,
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