Synthetic Route of 41253-21-8, New Advances in Chemical Research in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 41253-21-8, name is Sodium 1,2,4-triazol-1-ide, molecular formula is C2H2N3Na, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
With a thermometer,Condenser tube,Add 120ml DMF to the 250ml four-mouth reaction bottle of the stirrerAnd 1,2,4-triazole sodium salt (18.5 g 203 mmol),Add 1-chloro-2-(4-chlorophenyl)-3-cyclopropylbutan-2-ol (44 g, 170 mmol),Heat to 100 C,Reaction 60-100min,Sampling analysis,When the content of 1-chloro-2-(4-chlorophenyl)-3-cyclopropylbutan-2-ol is less than 1%,It is considered as the end of the reaction.Cool to room temperature,The reaction droplets were added to 120 ml of cold water.Stir the precipitated solid,filter,Washed,dry,A cyclic azole solvent having a content of 96% is obtained.The weight yield is 90%.
Future efforts will undeniably focus on the diversification of the new catalytic transformations. These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. Keep reading other articles of 41253-21-8.
Reference:
Patent; Huai’an Guorui Chemical Co., Ltd.; Zhang Pu; Jin Yucun; Li Ming; Chen Chao; Zhong Yu; Chen Mingguang; Wang Fengyun; (12 pag.)CN109400541; (2019); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics