Category: Triazoles. In 2020.0 BIOORG CHEM published article about BIOLOGICAL EVALUATION; TOPOISOMERASE-I; ANTICANCER; DESIGN; INHIBITORS; CHALCONES; ANALOGS; SERIES in [Radwan, Mohamed A. A.; Alshubramy, Maha A.; Abdel-Motaal, Marwa] Qassim Univ, Dept Chem, Collage Sci, Buraydah, Saudi Arabia; [Radwan, Mohamed A. A.] Natl Res Ctr, Dept Appl Organ Chem, Dokki, Egypt; [Abdel-Motaal, Marwa] El Mansoura Univ, Fac Sci, Dept Chem, Mansoura, Egypt; [Hemdan, Bahaa A.] Natl Res Ctr, Water Pollut Res Dept, Environm Microbiol Lab, 33 El Bohouth St, Giza 12622, Egypt; [El-Kady, Dina S.] Natl Res Ctr, Hormones Dept, Cairo, Egypt in 2020.0, Cited 56.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.
Synthesis of some new heterocyclic ring systems incorporated pyrimidine and pyridine moieties starting from 1-(furan-2-yl)-3-(thiophen-2-yl) chalcone was achieved. The structure of the new compounds was interpreted by spectral studies and ESI-MS analysis. Antimicrobial investigations of the designated compounds were performed towards some harmful pathogenic microbes. Antimicrobial tests proved that compound 11 unveiled a greater antimicrobial activity than other designed compounds. Docking of compound 11 into active site of DNA gyrase B chain displayed binding-energy of -13.05 kJ mol(-1) and distance at 3.18 A degrees. Furthermore, docking investigation was approved for the goal compounds into DNA gyrase B chain and exhibiting binding energy extended from -13.05 to -20.48 kJ mol(-1).
Welcome to talk about 61-82-5, If you have any questions, you can contact Radwan, MAA; Alshubramy, MA; Abdel-Motaal, M; Hemdan, BA; El-Kady, DS or send Email.. Category: Triazoles
Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
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