Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Zhang, Maoyuan, once mentioned the application of 288-88-0, Name is 1H-1,2,4-Triazole, molecular formula is C2H3N3, molecular weight is 69.0653, MDL number is MFCD00005228, category is Triazoles. Now introduce a scientific discovery about this category, HPLC of Formula: C2H3N3.
Cu(I)-N-heterocyclic carbene-catalyzed base free C-N bond formation of arylboronic acids with amines and azoles
A new N-heterocyclic carbene (NHC) precursor of imidazolium chloride and its corresponding Cu(I)-NHC complex 1 was synthesized. The complex 1 was found to be a highly effective catalyst for Chan-Evans-Lam coupling of arylboronic acid with amines and azoles (including imidazole, pyrazole and triazole), without addition of base at room temperature. Various substituents on three substrates can be tolerated, giving the desired coupling products in good to excellent yields (62-94%). The method is practical and offers an alternative to the corresponding copper-catalyzed Chan-Evans-Lam process for the construction of C-N bonds. (C) 2020 Published by Elsevier Ltd.
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