Racemization studies during solid-phase peptide synthesis using azabenzotriazole-based coupling reagents was written by Carpino, Louis A.;El-Faham, Ayman;Albericio, ernando. And the article was included in Tetrahedron Letters in 1994.Electric Literature of C17H27F6N7OP2 The following contents are mentioned in the article:
1-Hydroxy-7-azabenzotriazole (HOAt) (I) and its corresponding uronium salts are more effective in avoiding racemization in a model solid-phase peptide segment coupling process than their benzotriazole analogs. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0Electric Literature of C17H27F6N7OP2).
((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeElectric Literature of C17H27F6N7OP2
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics