Category: 1001401-62-2

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 2-(2H-1,2,3-Triazol-2-yl)benzoic acid

A solution of 2-(2H-l,2,3-triazol-2-yl)benzoic acid (60.5 mg, 0.320 mmol) and methyl 4-methoxy-2-(((3i?,6i?)-6-methylpiperidin-3-yl)amino)nicotinate (74.5 mg, 0.267 mmol) in DMF (1778 mu) was treated with l-hydroxy-7-azabenzotriazole (72.6 mg, 0.533 mmol), EDC (102 mg, 0.533 mmol), and triethylamine (112 muEpsilon, 0.800 mmol) and heated at 50 C overnight. The reaction was cooled, diluted with water and saturated aqueous sodium bicarbonate, and extracted 2x with EtOAc. The combined organic fractions were washed with brine, dried over magnesium sulfate, filtered, and concentrated. The residue was purified by silica gel gradient chromatography (0-95% EtOAc in hexanes), providing the title compound. HRMS m/z (M+H) 451.2070 found, 451.2088 required

The synthetic route of 1001401-62-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; SKUDLAREK, Jason, W.; WO2015/95441; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, A new synthetic method of this compound is introduced below., COA of Formula: C9H7N3O2

Step (vii): tert-butyl N-{4-[(4-methoxyphenyl)methoxy]-2-[2-(2H-l,2,3-triazol-2- yl)benzamido]cyclopentyl}carbamate To a solution of ieri-butyl N-{2-amino-4-[(4- methoxyphenyl)methoxy]cyclopentyl}carbamate (1.71 g, 5.08 mmol) in dry DMF (17 ml) was added 2-(2H-l,2,3-triazol-2-yl)benzoic acid (CAS number 1001401 -62-2; 1.058 g, 5.59 mmol), HATU (2.90 g, 7.62 mmol) and triethylamine (2.125 ml, 15.25 mmol). The reaction was stirred at room temperature for 72 hours. The reaction was partitioned between ethyl acetate and water, washed with brine, dried over magnesium sulfate, concentrated in vacuo and purified by column chromatography (silica, 0-100% ethyl acetate / petrol) to afford the title compound. 1H NMR (400 MHz, DMSO-d6) delta ppm 1.37 (s, 9 H), 1.46 – 1.59 (m, 1 H), 1.58 – 1.77 (m, 1 H), 1.86 – 1.97 (m, 1 H), 2.18 – 2.37 (m, 1 H), 3.67 – 3.79 (m, 4 H), 3.83 – 4.01 (m, 2 H), 4.32 (s, 2 H), 6.85 – 6.95 (m, 2 H), 7.17 – 7.31 (m, 2 H), 7.44 – 7.54 (m, 2 H), 7.55 – 7.66 (m, 1 H), 7.76 (s, 1 H), 7.96 – 8.05 (m, 2 H)MS ES+: 508

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; TAKEDA CAMBRIDGE LIMITED; TAKEDA PHARMACEUTICAL COMPANY LIMITED; FIELDHOUSE, Charlotte; GLEN, Angela; ROBINSON, John Stephen; FUJIMOTO, Tatsuhiko; WO2015/55994; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Electric Literature of 1001401-62-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below.

A solution of (3R, 6R)-6-methylpiperidin-3-ol (5.31 g, 46.1 mmol), 2-(2H-l,2,3- triazol-2-yl)benzoic acid (10.5 g, 55.3 mmol), EDC (17.7 g, 92.0 mmol), l-hydroxy-7- azabenzotriazole (12.6 g, 92.0 mmol), and triethylamine (19.3 mL, 138 mmol) in DMF (300 mL) was stirred at 50 C overnight, then diluted with saturated aqueous sodium bicarbonate and extracted 3x with ethyl acetate. The organics were washed with brine, dried over magnesium sulfate, filtered, and concentrated. The crude material was purified by silica gel gradient chromatography (0-100% ethyl acetate in hexanes), providing the titled compound as a pale yellow solid. LRMS m/z (Mu+Eta) 287.3 found, 287.1 required.

The synthetic route of 2-(2H-1,2,3-Triazol-2-yl)benzoic acid has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; SKUDLAREK, Jason, W.; WO2014/137883; (2014); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, A new synthetic method of this compound is introduced below., COA of Formula: C9H7N3O2

A mixture of [4-(hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-6-methoxy-pyrimidin-2-yl]- dimethyl-amine (60.0 mg, 0.23 mmol), 2-[1 ,2,3]triazol-2-yl-benzoic acid (47.4 mg, 0.25 mmol), HATU (130.0 mg, 0.34 mmol) and DIPEA (0.12 mL, 0.68 mmol) was stirred into DMF (4.0 mL) at room temperature for 30 minutes. The reaction mixture was diluted with ethyl acetate (60.0 mL) and washed with water (2X 100 mL). The organic phase was dried (Na2SO4), filtered and concentrated to dryness. The crude product was purified using Agilent HPLC (Basic system) to yield pure title compound (47.0 mg, 47.5 %). MS (ESI) mass calcd. for C22H26N8O2, 434.5; m/z found [M+H]+. 1H NMR (CDCI3): 7.98 (d, J = 8.1 , 1 H), 7.73 (s, 2H), 7.75 (s, 2H), 7.55-7.47 (m, 1 H), 7.45-7.37 (m, 2H), 5.00- 4.90 (m, 1 H), 3.91 -3.80 (m, 5H), 3.70 (dd, J = 12.5, 3.9, 2H), 3.60-3.29 (m, 4H), 3.19-3.04 (m, 8H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; CHAI, Wenying; LETAVIC, Michael, A.; LY, Kiev, S.; PIPPEL, Daniel, J.; RUDOLPH, Dale, A.; SAPPEY, Kathleen, C.; SAVALL, Brad, M.; SHAH, Chandravadan, R.; SHIREMAN, Brock, T.; SOYODE-JOHNSON, Akinola; STOCKING, Emily, M.; SWANSON, Devin, M.; WO2011/50198; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1001401-62-2, Quality Control of 2-(2H-1,2,3-Triazol-2-yl)benzoic acid

A solution of (R)-tert-butyl 5-methyl-l,4-diazepane-l-carboxylate Int A (2.50 g, 11.7 mmol) in DMF (50 mL) was treated with Int H (2.21 g, 11.7 mmol), HATU (4.47 g, 11.8 mmol), and DIEA (4.89 ml, 28.0 mmol). The reaction was stirred at room temperature overnight, then diluted with saturated, aqueous NH4CI. The solution was extracted with EtOAc (2x) and the organics were subsequently washed with brine, then with water, then with brine again, dried over MgS04, filtered, and concentrated. The crude material was purified by silica gel gradient chromatography (0-60% ethyl acetate in hexanes), providing 1-1 as an oil. LRMS m/z (M+H) 386.2 found, 386.2 required.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; REGER, Thomas, S.; SKUDLAREK, Jason, W.; (0 pag.)WO2016/85784; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Reference of 1001401-62-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, This compound has unique chemical properties. The synthetic route is as follows.

Step (vii): tert-Butyl N-{4-[(4-methoxyphenyl)methoxy]-2-[2-(2H-1,2,3-triazol-2-yl)benzamido]cyclopentyl}carbamate To a solution of tert-butyl N-{2-amino-4-[(4-methoxyphenyl)methoxy]cyclopentyl}-carbamate (1.71 g, 5.08 mmol) in dry DMF (17 ml) was added 2-(2H-1,2,3-triazol-2-yl)benzoic acid (CAS number 1001401-62-2; 1.06 g, 5.59 mmol), HATU (2.90 g, 7.62 mmol) and triethylamine (2.13 ml, 15.25 mmol). The reaction was stirred at room temperature for 72 hours then partitioned between ethyl acetate and water. The organics were washed with brine, dried over magnesium sulfate, filtered and concentrated in vacuo. The crude material was purified by column chromatography (silica, 0-100% ethyl acetate petrol) to afford the title compound. 1H NMR (400 MHz, DMSO-d6) delta ppm 1.37 (s, 9H), 1.46-1.59 (m, 1H), 1.58-1.77 (m, 1H), 1.86-1.97 (m, 1H), 2.18-2.37 (m, 1H), 3.67-3.79 (m, 4H), 3.83-4.01 (m, 2H), 4.32 (s, 2H), 6.85-6.95 (m, 2H), 7.17-7.31 (m, 2H), 7.44-7.54 (m, 2H), 7.55-7.66 (m, 1H), 7.76 (s, 1H), 7.96-8.05 (m, 2H) MS ES+: 508

The chemical industry reduces the impact on the environment during synthesis 2-(2H-1,2,3-Triazol-2-yl)benzoic acid. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Takeda Pharmaceutical Company Limited; Fieldhouse, Charlotte; Glen, Angela; Maine, Stephanie; Fujimoto, Tatsuhiko; Robinson, John Stephen; US2015/232460; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below. name: 2-(2H-1,2,3-Triazol-2-yl)benzoic acid

A solution of 2-(2H-1,2,3-triazol-2-yl)benzoic acid (4.3 g, 0.023 mol) in 15 mL of 50C12 was heated at 50 C for 30 mins. After cooling to RT, the mixture was concentrated in vacuo to remove the solvent. To a solution of the product from step 1 (3.3 g, 0.02 mol) and TEA (8.7 mL, 0.06 mol) in dry DCM (10 mL) at 0 C was added a solution of the above residue inDCM (10 mL) dropwise. The resulting mixture was stirred at RT overnight. The mixture was filtered and the filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography (50% EtOAc in petroleum ether) to give the title compound as an oil. LRMS m/z (M+H) 331.1 found, 331.2 required.

The synthetic route of 1001401-62-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; LIVERTON, Nigel; LUO, Yunfu; (58 pag.)WO2016/89722; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1001401-62-2, Product Details of 1001401-62-2

A solution of 2-(2H-1,2,3-triazol-2-yl)benzoic acid (500 mg, 2.64 mmol) in SOCl2 (5 mL) was heated to reflux for 1 h, cooled to RT and concentrated in vacuo. The residue was dissolved in toluene (5 mL) and added to a solution of ((3R,6R)-6-methylpiperidin-3-yl)methanol hydrochloride (437 mg,2.65 mmol) in toluene (5 mL), followed by addition of aq. NaOH (5.3 mL, 1M, 5.3mmol). The resulting mixture was stirred at 10C for 12 h, poured into water (5mL) and extracted with EtOAc (5 mLx3). The combined organic layers were dried over Na2S04, filtered and concentrated in vacuo. The residue was purified by chromatography on silica (20-50 % EtOAc in petroleum ether) to afford the title compound as a solid. LRMS 25 m/z (M+H) 301.1 found, 301.2 required.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, and friends who are interested can also refer to it.

Reference:
Patent; MERCK SHARP & DOHME CORP.; LIVERTON, Nigel; KUDUK, Scott D.; BESHORE, Douglas; LUO, Yunfu; MENG, Na; YU, Tingting; (114 pag.)WO2016/65585; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

1001401-62-2,Some common heterocyclic compound, 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, molecular formula is C9H7N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of [6-(hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-2-trifluoromethyl-pyrimidin- 4-yl]-dimethyl-amine (50 mg, 0.17 mmol), 2-[1 ,2,3]triazol-2-yl-benzoic acid (34.5 mg, 0.18 mmol), HATU (94.6 mg, 0.25 mmol) and DIPEA (0.09 mL, 0.50 mmol) in DMF (4.0 mL) was stirred at room temperature for 30 minutes. The reaction mixture was diluted with ethyl acetate (60.0 mL) and washed with water (2 X 100 mL). The organic phase was dried (Na2SO4), filtered and concentrated to dryness. The crude product was purified using Agilent HPLC (Basic system) to yield pure title compound (34.0 mg, 43.4 %). MS (ESI) mass calcd. for C22H23F3N8O, 472.47; m/z found 473.2 [M+H]+ 1 H NMR (CDCI3): 7.98 (d, J = 8.1 , 1 H), 7.70-7.69 (m, 2H), 7.56-7.49 (m, 1 H), 7.45-7.37 (m, 2H), 5.20- 5.10 (m, 1 H), 3.90-3.66 (m, 4H), 3.60-3.28 (m, 4H), 3.08 (s, 6H), 3.02-2.89 (m, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1001401-62-2, its application will become more common.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; CHAI, Wenying; LETAVIC, Michael, A.; LY, Kiev, S.; PIPPEL, Daniel, J.; RUDOLPH, Dale, A.; SAPPEY, Kathleen, C.; SAVALL, Brad, M.; SHAH, Chandravadan, R.; SHIREMAN, Brock, T.; SOYODE-JOHNSON, Akinola; STOCKING, Emily, M.; SWANSON, Devin, M.; WO2011/50198; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

1001401-62-2, Adding a certain compound to certain chemical reactions, such as: 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1001401-62-2.

A solution of2-(2H-1,2,3-triazol-2-yl)benzoic acid (P. Coleman, J. Schreier,W02007/126934) (1 g, 4.1 mmol) in SOCb (10 mL) was stirred at 80 C for 30 min. Thesolvent was removed under reduced pressure and toluene (10 mL) was added to give solution A.The product from step 4 (1 g, 4.1 mmol) was dissolved in DCM (10 mL), DIEA (1.58 g, 1225 mmol) added, and then solution A added at 0 C. The resulting mixture was stirred at RT for 2 h,then poured into water (10 mL) and extracted with DCM (10 mL x 3). The combined organiclayers were washed with brine (10 mL), dried overNa2S04, filtered and concentrated in vacuo.The residue was purified by chromatography on silica (petroleum ether : EtOAc = 10 : 1 to = 3 :1) then purified by prep. TLC (petroleum ether: EtOAc = 1 : 1) to give the title compound (0.230 g). LRMS m/z (M+H) 416.0, 418.0 found, 416.1, 418.1 required

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME CORP.; BESHORE, Douglas C.; KUDUK, Scott D.; LIVERTON, Nigel; LUO, Yunfu; MENG, Na; YU, Tingting; WO2015/18029; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics