Category: 103755-58-4

New discoveries in chemical research and development in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 103755-58-4, name is (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C9H9N3O

General procedure: Into a round-bottom flask were added 5.71mmolof alditolyl-triazole 12 or 21a in 50ml dichloromethane, 0.9mL of pyridine (2 eq.), 5.71mmolof acyl chloride and catalytic amount of DMAP. The mixture was stirred vigorously at room temperature, and the reaction progress was monitored by thin layer chromatography. Next, the mixture was washed with distilled water (3×100mL), saturated sodium bicarbonate solution (5×100mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The product was purified via silica-gel column chromatography using gradient mixture of hexane-ethyl acetate, to afford the pure derivatives 13a-k and 22a-d.

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Reference:
Article; Gonzaga, Daniel; Senger, Mario Roberto; Da Silva, Fernando De Carvalho; Ferreira, Vitor Francisco; Silva Jr., Floriano Paes; European Journal of Medicinal Chemistry; vol. 74; (2014); p. 461 – 476;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Related Products of 103755-58-4, New Advances in Chemical Research in 2021. The appropriate choice of redox mediator can avoid electrode passivation and overpotential, which strongly inhibit the efficient activation of substrates in electrolysis. 103755-58-4, name is (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol, molecular formula is C9H9N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

(1-Phenyl-1H-1,2,3-triazol-4-yl)methanol (0.37 g, 2.0 mmol) was added at 0 C to a mixture of potassium hydroxide (0.64 g, 5.0 mmol) and p-toluenesulfonyl chloride (0.45 g, 2.2 mmol) in tetrahydrofuran (8 mL). The mixture was stirred at room temperature for 3 h. The mixture was then diluted with ethyl acetate (20 mL) and washed with water (2 x 20 mL). The organic layer was dried over with MgSO4, concentrated in vacuo and the obtained crude product was purified by column chromatography (ethyl acetate/hexanes, 3:7) on a silica gel to give compound 2 (0.33 g, 50%) as a white solid; m.p. 104-106 oC. 1H NMR (300 MHz, CDCl3): delta = 8.00 (s, 1 H), 7.82 (d, J = 8.3 Hz, 2 H), 7.69-7.65 (m, 2 H), 7.56-7.43 (m, 3 H), 7.34 (d, J = 8.0 Hz, 2 H), 5.30 (d, J = 0.3 Hz, 2 H), 2.43 (s, 3 H). 13C NMR (75 MHz, CDCl3): delta = 145.3, 141.8, 136.8, 133.1, 130.1, 130.0, 129.3, 128.1, 122.3, 120.7, 63.2, 21.7. HRMS (ESI): calcd. for C16H16N3O3S [M + H]+ 330.0912; found 330.0913.

In the meantime we’ve collected together some recent articles in this area about (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol to whet your appetite. Happy reading!

Reference:
Article; Kwon, Young-Do; Son, Jeongmin; Yun, Mijin; Chun, Joong-Hyun; Tetrahedron Letters; vol. 59; 29; (2018); p. 2848 – 2852;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Electric Literature of 103755-58-4, New Advances in Chemical Research in 2021.In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 103755-58-4, name is (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol, molecular formula is C9H9N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

Example 12: (R)-3-(l-Phenyl-cycloheptanecarbonyloxy)-l-(l-phenyl-lH- [1, 2,3]triazol-4-ylm ethyl)- l-azonia-bicyclo[2.2.2]octane chloridea) 4-Chloromethyl- 1 -phenyl- lH-[ 1 ,2,3]triazole (1 -Phenyl- IH-[1, 2, 3]triazol-4-yl)-methanol (700 mg) was treated with thionyl chloride (2 mL) in dichloromethane (10 mL). The mixture was stirred and heated under reflux to form a solution. The excess reagent and solvent were removed and the residue dissolved in dichloromethane (50 mL) and passed down a plug of silica gel. The silica was washed with dichloromethane followed by ether and the eluants combined and concentrated to afford the sub-titled compound as a crystalline solid (600 mg).1H NMR (399.826 MHz, CDCl3) delta 8.00 (s, IH), 7.73 – 7.68 (m, 2H), 7.54 – 7.48 (m, 2H), 7.47 – 7.41 (m, IH), 4.77 (s, 2H).

The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.I hope my blog about (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol is helpful to your research.

Reference:
Patent; ASTRAZENECA AB; ARGENTA DISCOVERY Ltd.; FORD, Rhonan; WO2009/139709; (2009); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application of 103755-58-4, New Advances in Chemical Research in 2021.In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 103755-58-4, name is (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol, molecular formula is C9H9N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

General procedure: Into a round bottom flask was added 5.71mmolof triazole type 12 or 21a in 50mL of dry THF, 17.13mmolof sodium hydride and 57.1mmolof alkyl bromide. The mixture was heated to reflux, and reaction progress was monitored by TLC. Subsequently, the solvent was evaporated and the mixture was extracted with ethyl acetate, washed with distilled water (3×100mL) and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the product was purified via silica-gel column chromatography using a gradient mixture of hexane-ethyl acetate, to afford the pure derivatives 14a-g and 23a-b.

I am very proud of our efforts over the past few months and hope to (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol help many people in the next few years.

Reference:
Article; Gonzaga, Daniel; Senger, Mario Roberto; Da Silva, Fernando De Carvalho; Ferreira, Vitor Francisco; Silva Jr., Floriano Paes; European Journal of Medicinal Chemistry; vol. 74; (2014); p. 461 – 476;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthetic Route of 103755-58-4, New Advances in Chemical Research in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 103755-58-4, name is (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol, molecular formula is C9H9N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

General procedure: 1-Azido-4-methylbenzenes 1 (0.3 mmol), propargyl alcohol 2 (0.36 mmol), CuI (0.03 mmol),NaAsc (0.06 mmol), and 2 mL solvent were added to a 15 mL pressure tube. The tube was thensealed, and the mixture was stirred at 80 C for 5 hours. After the reaction completed, the abovesystem was added with KMnO4 (0.75 mmol) and Na2CO3 (0.45 mmol), and stirred at 80 C for 8h until the reaction completed. Then, Ag2O (0.03 mmol) and K2S2O7 (0.6 mmol) were added tothe tube and the mixture was conducted at 100 C for 24 h until the transformation finished byTLC analysis. H2O (25 mL) was added to the mixture and the system was extracted with EtOAc (3× 20 mL). The combined organic layer was washed with brine (3 × 5 mL), dried with Na2SO4, andconcentrated under reduced pressure to afford the crude product. Purification by columnchromatography on silica gel with EtOAc-PE (1:3) afforded the desired product 3.

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Reference:
Article; Han, Chunmei; Dong, Suping; Zhang, Wensheng; Chen, Zhen; Synlett; vol. 29; 5; (2018); p. 673 – 677;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Research speed reading in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 103755-58-4, name is (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol

Methanesulfonyl chloride (0.30 g, 2.6 mmol) was added at 0 C to a solution of (1-phenyl-1H-1,2,3-triazol-4-yl)methanol (0.16 g, 0.87 mmol) and trimethylamine (0.38 mL, 2.6 mmol) in dichloromethane (10 mL). The mixture was stirred at 0 C for 45 min. The mixture was washed with water (20 mL). The organic layer was dried over with MgSO4, evaporated and purified by column chromatography (ethyl acetate/hexane, 1:1.2) on silica gel to yield compound 3 (0.15 g, 70%) as a white solid; m.p. 110-112 C. 1H NMR (300 MHz, CDCl3): delta = 8.15 (s, 1 H), 7.76-7.72 (m, 2 H), 7.58-7.45 (m, 3 H), 5.47 (s, 2 H), 3.09 (s, 3 H). 13C NMR (75 MHz, CDCl3): delta = 141.9, 136.8, 130.0, 129.4, 122.7, 120.8, 62.4, 38.5. HRMS (ESI): calcd. for C10H12N3O3S [M + H]+ 254.0599; found 254.0599.

The catalyzed pathway has a lower Ea, but the net change in energy that results from the reaction is not affected by the presence of a catalyst. In my other articles, you can also check out more blogs about 103755-58-4

Reference:
Article; Kwon, Young-Do; Son, Jeongmin; Yun, Mijin; Chun, Joong-Hyun; Tetrahedron Letters; vol. 59; 29; (2018); p. 2848 – 2852;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

New discoveries in chemical research and development in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 103755-58-4, name is (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 103755-58-4

General procedure: Into a round-bottom flask equipped with a magnetic stirring bar already containing a solution of 10mmolof 1,2,3-triazoles type 12 in 27.5mL of DMSO was added 11mmolof IBX. This mixture was stirred at room temperature for 4h. Next, distilled water (20mL) was added, and stirring was continued for 15minat room temperature. Subsequently, the mixture was filtered, extracted with ethyl acetate and dried over with MgSO4. The product was purified via silica-gel column chromatography using gradient mixture of hexane-ethyl acetate to afford the pure derivatives 11 and 15a-b.

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Reference:
Article; Gonzaga, Daniel; Senger, Mario Roberto; Da Silva, Fernando De Carvalho; Ferreira, Vitor Francisco; Silva Jr., Floriano Paes; European Journal of Medicinal Chemistry; vol. 74; (2014); p. 461 – 476;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Electric Literature of 103755-58-4, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 103755-58-4, name is (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Phosphorus(III) bromide, 9.7 mL (0.05 mol), was added with vigorous stirring to a solution of 8.75 g (0.05 mol) of (1-phenyl-1H-1,2,3-triazol-4-yl)metha-nol (11) in 200 mL of anhydrous benzene. The mixture was heated for 2 h and cooled, 50 g of crushed ice was added, and the mixture was neutralized with a saturat-ed solution of sodium carbonate. The organic layer was separated and washed with a saturated solution of sodium carbonate, and the solvent was evaporated under reduced pressure. Yield 10.0 g (84%), mp 124-126C. 1 H NMR spectrum (500 MHz, DMSO-d 6 ), delta, ppm: 4.84 s (2H, CH 2 ), 7.52 t (1H, p-H, J = 7.2 Hz), 7.62 t (2H, m-H, J = 7.2 Hz), 8.92 s (1H, 5-H), 7.91 d (2H o-H, J = 7.2 Hz). Mass spectrum, m/z (I rel , %): 238 (100), 240 (97) [M + H] + . Found, %: C 45.23; H 3.30; N 17.62. C 9 H 8 BrN 3 . Calculated, %: C 45.40; H 3.39; N 17.65.

Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.In my other articles, you can also check out more blogs about (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol.

Reference:
Article; Pokhodylo; Tupychak; Shyyka, O. Ya.; Obushak; Russian Journal of Organic Chemistry; vol. 55; 9; (2019); p. 1310 – 1321; Zh. Org. Khim.; vol. 55; 9; (2019); p. 1393 – 1405,13;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

New discoveries in chemical research and development in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 103755-58-4, name is (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C9H9N3O

General procedure: A 10mL microwave tube was loaded with6a(1.4mmol), paraformaldehyde (4mmol), the appropriate alcohol (4.5mmol) and were irradiated for 20min. The internal temperature reached 150C. The alcohol excess was evaporated under reduced pressure. The residual solid product was purified by column chromatography on silica gel and eluted with an increasing polarity gradient mixture of hexane and ethyl acetate (9/1). For the product 7e was used 5mL of chloroform as solvent.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol, in my other articles.

Reference:
Article; Jordao, Alessandro K.; Novais, Juliana; Leal, Bruno; Escobar, Ana C.; Dos Santos Junior, Helvecio M.; Castro, Helena C.; Ferreira, Vitor F.; European Journal of Medicinal Chemistry; vol. 63; (2013); p. 196 – 201;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Related Products of 103755-58-4, New Advances in Chemical Research in 2021.In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 103755-58-4, name is (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol, molecular formula is C9H9N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

Step 2 Synthesis of 1-Phenyl-1H-[1,2,3]triazole-4-carbaldehyde MnO2 (1.23 g, 14.14 mmol) was added to a stirred solution of (1-phenyl-1H-[1,2,3]triazol-4-yl)-methanol (245 mg, 1.4 mmol) in DCM (15 mL) and the resulting mixture was stirred at room temperature overnight. The mixture was filtered over a celite bed, and the filtrate was concentrated under reduced pressure to afford 271 mg (99%) of 1-phenyl-1H-[1,2,3]triazole-4-carbaldehyde.

The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol, hurry up and to see.

Reference:
Patent; Bischoff, Alexander; Subramanya, Hosahalli; Sundaresan, Kumar; Sammeta, Srinivasa Raju; Vaka, Anil Kumar; US2010/160323; (2010); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics