Category: 10570-40-8

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10570-40-8, name is 4-Methyl-4H-1,2,4-triazole, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C3H5N3

Step 1. This step is the same as the preparation of Step 1 in Example 1.Step 2. 40 mmol of 4-methyl-1,2,4-triazole and 100 mmol of vinyl chloride were stirred under nitrogen at 70 C, and condensed and refluxed for 36 h to complete the quaternization reaction, and the reaction product was washed with carbon tetrachloride. Rotary steaming to obtain a light yellow liquid1,2-Divinyl-4-methyl-1,2,4-triazole chloride 7.65 g.

According to the analysis of related databases, 10570-40-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Nanjing Tech University; Guan Guofeng; Ding Jing; He Yuting; Li Xue; Yuan Dashui; Wan Hui; Wang Lei; (9 pag.)CN108250227; (2018); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthetic Route of 10570-40-8, The chemical industry reduces the impact on the environment during synthesis 10570-40-8, name is 4-Methyl-4H-1,2,4-triazole, I believe this compound will play a more active role in future production and life.

General procedure: A solution of 1,4-dichloro-2-butyne (1.23 g, 10 mmol) and the respective N-alkylazole (20 mmol) in MeCN (15 mL) was stirred at 80 C for 24 h. The precipitate wascollected by filtration, washed with MeCN, and dried under reduced pressure.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Methyl-4H-1,2,4-triazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Haslinger, Simone; Laus, Gerhard; Oberparleiter, Stefan; Wurst, Klaus; Kahlenberg, Volker; Nerdinger, Sven; Schreiner, Erwin; Schottenberger, Herwig; Heterocycles; vol. 95; 2; (2017); p. 1148 – 1158;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthetic Route of 10570-40-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 10570-40-8 as follows.

Step 2. 40 mmol of 4-methyl-1,2,4-triazole and 80 mmol of ethyl chloride were stirred at 60 C under nitrogen atmosphere, and quaternized and refluxed for 24 h to cause quaternization reaction.The reaction product was washed with n-hexane and rotary evaporated to give a pale yellow liquid.1,2-Diethyl-4-methyl-1,2,4-triazole chloride 7.80 g

According to the analysis of related databases, 10570-40-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Nanjing Tech University; Guan Guofeng; Ding Jing; He Yuting; Li Xue; Yuan Dashui; Wan Hui; Wang Lei; (9 pag.)CN108250227; (2018); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10570-40-8, name is 4-Methyl-4H-1,2,4-triazole, A new synthetic method of this compound is introduced below., category: Triazoles

4.2 1-(4-Methyl-4H-1,2,4-triazol-3-yl)octan-1-ol To a solution of 4-methyl-1,2,4-triazole (681 mg, 7.78 mmol), TMEDA (0.40 ml) in dry THF (10 ml) and at -60 C, 2.69 M n-BuLi solution (2.9 ml, 7.80 mmol) was added drop wise. After stirring at -60 C for 30 min, 10 ml of dry THF solution of octanol (1.30 mL, 8.33 mmol) was added and the mixture was stirred for additional 4 h at -60 C to -30 C. Then H2O was added and the mixture was extracted three times with ethyl acetate. The organic layer was washed with saturated brine and dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (1-5% methanol/chloroform) as a colorless solid (1.13 g, 69%): Mp. 63-65 C; 1H NMR (500 MHz, CDCl3) delta 0.87 (3H, t, J = 6.6 Hz), 1.30-1.26 (9H, m), 1.46 (1H, q, J = 5.2 Hz), 1.93-1.84 (2H, m), 3.50 (1H, br s), 3.93 (3H, s), 4.82 (1H, q, J = 6.3 Hz), 7.76 (1H, s); 1H NMR (300 MHz, DMSO) delta 0.88 (3H, t, J = 6.9 Hz), 1.26-1.49 (14H, m), 1.87-1.93 (2H, m), 2.70 (1H, d, J = 7.5 Hz) 3.92 (3H, s), 4.84 (1H, q, J = 6.9 Hz), 7.79 (1H, s); 13C NMR (126 MHz) delta 14.1, 22.7, 25.2, 29.5, 31.9, 33.7, 35.4, 39.8, 64,2, 143.6, 155.0; HRMS (ESI) m/z calcd for C11H21N3NaO (M + Na)+ 234.1582, found. 234.1573.

The synthetic route of 10570-40-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Suzuki, Yumiko; Iwata, Naoto; Dobashi, Kohei; Takashima, Ryo; Arulmozhiraja, Sundaram; Ishitsubo, Erika; Matsuo, Naoya; Tokiwa, Hiroaki; Tetrahedron; vol. 74; 3; (2018); p. 392 – 400;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

These common heterocyclic compound, 10570-40-8, name is 4-Methyl-4H-1,2,4-triazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 4-Methyl-4H-1,2,4-triazole

Step 2. 40 mmol of 4-methyl-1,2,4-triazole and 120 mmol of propargyl chloride were stirred under nitrogen at 90 C, and condensed and refluxed for 48 h to complete the quaternization reaction.The reaction product is washed with carbon tetrachloride and steamed to obtain a pale yellow liquid.1,2-Dipropargyl-4-methyl-1,2,4-triazole chloride 8.35 g.

The synthetic route of 4-Methyl-4H-1,2,4-triazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nanjing Tech University; Guan Guofeng; Ding Jing; He Yuting; Li Xue; Yuan Dashui; Wan Hui; Wang Lei; (9 pag.)CN108250227; (2018); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics