Category: 129027-65-2

Reference of 129027-65-2, New Advances in Chemical Research in 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic,A common heterocyclic compound, 129027-65-2, name is 1-(tert-Butyl)-1H-1,2,3-triazole-4-carbaldehyde, molecular formula is C7H11N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

To a 250-mL round bottom flask was added a solution of 1-tert-butyl-1H-1,2,3-triazole-4-carbaldehyde (2.47 g, 16.1 mmol, 2.2 eq) in dichloroethane, followed by addition of propargyl amine (361 mg, 72 mmol, 1.0 eq). To this mixture sodium triacetoxyborohydride (3.8 g, 17.9 mmol, 2.5 eq) was added in one portion with vigorous stirring. The reaction mixture was stirred at room temperature for 40 h. 1N H2SO4 (86 mL) was added to the reaction, and the mixture was stirred for 15 min. The pH was adjusted to >10 by addition of potassium carbonate. The reaction mixture was diluted with water (100 mL) and extracted with dichloromethane (3×300 mL). The organic layers were combined, dried over anhydrous MgSO4, and filtered. Solvent was removed and the residue was purified on column to afford the product as a white powder. 1H NMR complies with the reported value.

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Reference:
Patent; UNIVERSITY OF PITTSBURGH – OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCACATION; Zeng, Dexing; (26 pag.)US2017/297008; (2017); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Reference of 129027-65-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 129027-65-2, name is 1-(tert-Butyl)-1H-1,2,3-triazole-4-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows.

To a 250-mL round bottom flask was added a solution of 1-tert-butyl-1H-1,2,3-triazole-4-carbaldehyde (2.47 g, 16.1 mmol, 2.2 eq) in dichloroethane, followed by addition of propargyl amine (361 mg, 72 mmol, 1.0 eq). To this mixture sodium triacetoxyborohydride (3.8 g, 17.9 mmol, 2.5 eq) was added in one portion with vigorous stirring. The reaction mixture was stirred at room temperature for 40 h. 1N H2SO4 (86 mL) was added to the reaction, and the mixture was stirred for 15 min. The pH was adjusted to >10 by addition of potassium carbonate. The reaction mixture was diluted with water (100 mL) and extracted with dichloromethane (3¡Á300 mL). The organic layers were combined, dried over anhydrous MgSO4, and filtered. Solvent was removed and the residue was purified on column to afford the product as a white powder. 1H NMR complies with the reported value.

The chemical industry reduces the impact on the environment during synthesis 1-(tert-Butyl)-1H-1,2,3-triazole-4-carbaldehyde. I believe this compound will play a more active role in future production and life.

Reference:
Patent; UNIVERSITY OF PITTSBURGH – OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCACATION; Zeng, Dexing; (26 pag.)US2017/297008; (2017); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 129027-65-2, name is 1-(tert-Butyl)-1H-1,2,3-triazole-4-carbaldehyde belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below. Safety of 1-(tert-Butyl)-1H-1,2,3-triazole-4-carbaldehyde

Synthesis of N,N-bis((1-tert-butyl-1H-1,2,3-triazol-4-yl)methyl)prop-2-yn-1-amine To a 250-mL round bottom flask was added a solution of 1-tert-butyl-1H-1,2,3-triazole-4-carbaldehyde (2.47 g, 16.1 mmol, 2.2 eq) in 84 mL dichloroethane (?0.2 M), followed by addition of propargyl amine (361 mg, 7.2 mmol, 1.0 eq). To this mixture sodium triacetoxyborohydride (3.8 g, 17.9 mmol, 2.5 eq) was added in one portion with vigorous stirring. The reaction mixture was stirred at rt for 40 h. 1N H2SO4 (86 mL) was added to the reaction, and the mixture was stirred for 15 min. The pH was adjusted to >10 by addition of potassium carbonate. The reaction mixture was diluted with 100 mL of water and extracted with dichloromethane (3*300 mL). The organic layers were combined, dried over anhydrous MgSO4, filtered, and concd in vacuo to provide a crude product.Further purification by flash chromatography (100 g silica gel, 20% hexanes in EtOAc, Rf 0.2, KMnO4 stain) provided 1.98 g of product (yield: 84%) as a white powder. mp 125.5-126.1 C.; 1H NMR (300 MHz, CDCl3) delta 7.67 (s, 2H), 3.87 (s, 4H), 3.40 (d, J=2.4 Hz, 2H), 2.28 (t, J=2.4 Hz, 1H), 1.67 (s, 18H); 13C NMR (75 MHz, CDCl3) delta 143.6, 120.2, 78.8, 73.5, 59.2, 47.8, 42.2, 30.0; HRMS cacld for [M+H]+ C17H28N7 330.2406, found 330.2400.

The synthetic route of 129027-65-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Albert Einstein College of Medicine of Yeshiva Uni; Wu, Peng; Soriano del Amo, David; Wang, Wei; Marlow, Florence L.; US2013/295019; (2013); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics