Category: 138624-97-2

Research speed reading in 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic. 138624-97-2, name is 1-Benzyl-1H-1,2,4-triazole-3-carboxylic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. name: 1-Benzyl-1H-1,2,4-triazole-3-carboxylic acid

A mixture of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimidehydrochloride (35 mg, 0.18 mmol), 6-amino-4-methyl-2-(tetrahydrofuran-3-ylmethyl)-7,8-dihydro-6H-pyrazolo[1,5-a][1,3]diazepin-5-one (40 mg, 0.15 mmol), 1-hydroxybenzotriazole (25 mg, 0.18 mmol) and 1-benzyl-1,2,4-triazole-3-carboxylic acid (34 mg, 0.17 mmol) in N,N-dimethylformamide (3 mL) was stirred at 25 C. for 12 h. The reaction mixture was concentrated under reduced pressure. The residue was purified by RP-HPLC (methanol 40%-70%/0.05% ammonia hydroxide in water) to afford 1-benzyl-N-[4-methyl-5-oxo-2-(tetrahydrofuran-3-ylmethyl)-7,8-dihydro-6H-pyrazolo[1,5-a][1,3]diazepin-6-yl]-1,2,4-triazole-3-carboxamide (30 mg, 43%) as a white solid.

In conclusion, we affirm that quantitative kinetic descriptions of catalytic behavior continue to serve as an indispensable tool to navigate research efforts intended to model. Read on for other articles about 138624-97-2.

Reference:
Patent; Genentech, Inc.; Patel, Snahel; Hamilton, Gregory; (73 pag.)US2018/170927; (2018); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 138624-97-2, name is 1-Benzyl-1H-1,2,4-triazole-3-carboxylic acid, A new synthetic method of this compound is introduced below., HPLC of Formula: C10H9N3O2

A mixture of 1-benzyl-1H-1,2,4-triazole-3-carboxylic acid (32 mg, 0.16 mmol), 1-(3- dimethylaminopropyl)-3-ethylcarbodiimidehydrochloride (28 mg, 0.14 mmol), 3-amino-i – methyl-4,5-dihydro-3h-pyrido [1,2-a] [1,3] diazepine-2,7-dione (25 mg, 0.12 mmol) and 1- hydroxybenzotriazole (20 mg, 0.14 mmol) in N,N-dimethylformamide (3 mL) was stuffed at 25 C for 12 h. The mixture was concentrated to dryness under reduce pressure. The resultingresidue was purified by reverse phase chromatography (acetonitrile 10-40% / 0.05% ammonia hydroxide in water) to afford 1 -benzyl-N-( 1 -methyl-2,7-dioxo- 1,2,3,4,5,7- hexahydropyrido [1,2-a] [1,3] diazepin-3-yl)- 1 H-i ,2,4-triazole-3-carboxamide (30 mg, 63%) as a white solid. The racemic material was further purified by SFC to give arbitrarily assigned:1 -benzyl-N-[(3S)- 1 -methyl-2,7-dioxo-4,5-dihydro-3H-pyrido[ 1,2-a] [1 ,3]diazepin-3-yl]-1,2,4-triazole-3-carboxamide (Peak 1, retention time = 5.180 mm) (12 mg, 40%) as white solids. ?H NMR (400 MHz, CD3OD) 5 8.57 (s, 1H), 7.64 – 7.56 (m, 1H), 7.47 – 7.25 (m, 5H), 6.53 (d, J = 9.2 Hz, 1H), 6.46 (d, J = 7.2 Hz, 1H), 5.47 (s, 2H), 5.07 – 5.03 (m, 1H),4.61 – 4.55 (m, 1H), 3.71 – 3.63 (m, 1H), 3.39 (s, 3H), 2.68 – 2.60 (m, 1H), 2.19 – 2.12 (m, 1H). LC-MS RT = 1.177 mm, mlz = 393.2 [M+H]. LCMS (10 to 80% acetonitrile in water +0.03% ammonium bicarbonate over 3.0 mins) retention time 1.177 mm, ESI+ found [M+H] =393.2.1 -benzyl-N- [(3R)- 1 -methyl-2,7-dioxo-4,5-dihydro-3H-pyrido [1,2-a] [1,3] diazepin-3-yl]-1,2,4-triazole-3-carboxamide. (Peak 2, retention time = 6.616 mm) (8 mg, 26%) as white solids. ?H NMR (400 MHz, CD3OD) (5 8.56 (s, 1H), 7.63 – 7.57 (m, 1H), 7.43 – 7.25 (m, 5H), 6.52 (d, J = 9.2 Hz, 1H), 6.45 (d, J = 7.2 Hz, 1H), 5.47 (s, 2H), 5.06 – 5.01 (m, 1H),4.59 – 4.56 (m, 1H), 3.69 – 3.62 (m, 1H), 3.39 (s, 3H), 2.68 – 2.60 (m, 1H), 2.19 – 2.12 (m, 1H). LC-MS RT = 1.179 mi mlz = 393.1 [M+Hf?. LCMS (10 to 80% acetonitrile in water +0.03% ammonium bicarbonate over 3.0 mins) retention time 1.179 mi ESI+ found [M+H] =393.1.SFC condition: column: chiralcel OD-3 100 x 4.6mm I.D., 3um mobile phase:A:C02 B: ethanol (0.05% DEA) gradient: hold 5% for 1.0 mm, then from 5% to 40% of B in 4.5 mm and hold 40% for 2.5 mm, then 5% of B for 1.0 mm. Flow rate: 2.8 mL/min. Columntemperature: 40 C.

The synthetic route of 138624-97-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; PATEL, Snahel; (105 pag.)WO2018/73193; (2018); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 138624-97-2 as follows. category: Triazoles

A mixture of 7-amino-i ,5-dimethyl- 8 ,9-dthydro-7H-pyrido [3,2-b] azepine-2,6-dione(20 mg, 0.09 mmol), i-(3-dimethylaminopropyl)-3-ethylcarbodiimidehydrochloride (26 mg,0.14 mmol), 1 -hydroxybenzotriazole (18.3 mg, 0.14 mmol) and 1 -benzyl- 1 ,2,4-triazole-3-carboxylic acid (22 mg, 0.11 mmol) in N,N-dimethylformamide (1 mL) was stuffed at 25 Cfor 12 h. The mixture was concentrated under reduced pressure. The residue was purified byRP-HPLC (acetonitrile 20-50%/0.05% ammonium hydroxide in water) to afford the racemicmaterial (30 mg), which was separated by chiral SFC to give arbitrarily assigned:1 -benzyl-N- [(7R)- 1 ,5-dimethyl-2,6-dioxo- 8 ,9-dihydro-7H-pyrido [3,2-b] azepin-7-yl] – i,2,4-triazole-3-carboxamide (Peak 1, retention time 2.38 mm) (8.1 mg, 25%) as white solids.?H NMR (400 MHz, CD3OD) oe 8.56 (s, 1H), 7.58 (d, J = 10.0 Hz, 1H), 7.36 – 7.34 (m, 5H),6.57 (d, J = 9.2 Hz, 1H), 5.47 (s, 2H), 4.67 – 4.62 (m, 1H), 3.68 (s, 3H), 3.29 (s, 3H), 3.06 -3.05 (m, 1H), 2.88 – 2.84 (m, 1H), 2.75 – 2.72 (m, 1H), 2.27 – 2.22 (m, 1H). LCMS RT =0.695 mm, mlz = 407.1 [M + H]. LCMS (5 to 95% acetonitrile in water + 0.03%trifluoacetic acid over 1.5 mins) retention time 0.695 mi ESI+ found [M+H] =407.1.1 -benzyl-N-[(7S)- 1 ,5-dimethyl-2,6-dioxo-8,9-dihydro-7H-pyrido[3,2-b] azepin-7-yl] -i,2,4-triazole-3-carboxamide (Peak 2, retention time 3.639 mm) (5.3 mg, 17%) as white solids. ?H NMR (400 MHz, CD3OD) oe 8.56 (s, 1H), 7.58 (d, J = 9.6 Hz, 1H), 7.37 – 7.33 (m, 5H), 6.57 (d, J = 10.0 Hz, 1H), 5.47 (s, 2H), 4.67 – 4.62 (m, 1H), 3.68 (s, 3H), 3.29 (s, 3H),3.10 – 3.05 (m, 1H), 2.88 – 2.86 (m, 1H), 2.75 – 2.72 (m, 1H), 2.27 – 2.22 (m, 1H). LCMS RT = 1.202 mi mlz = 407.2 [M + H]. LCMS (10 to 80% acetonitrile in water + 0.05%ammonium hydroxide over 3 mins) retention time 1.202 mi ESI+ found [M+H] = 407.2. SFC condition: Column: Chiralpak AD-3 100×4.6mm I.D., 3um Mobile phase: A:C02 B: methanol (0.05% DEA) Gradient: from 5% to 40% of B in 5mm and hold 40% for 2.5 mm, then 5% of B for 2.5 mm Flow rate: 2.8mL/min Column temp.: 40 C.

According to the analysis of related databases, 138624-97-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; PATEL, Snahel; (105 pag.)WO2018/73193; (2018); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

138624-97-2, name is 1-Benzyl-1H-1,2,4-triazole-3-carboxylic acid, belongs to triazoles compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 138624-97-2

M-30 (25 mg) was dissolved in 2 mL of dichloromethane and 1 mL of trifluoroacetic acid, and after 1 hour of reaction, the solvent was spin-dried to obtain the intermediate amine. Subsequently, the intermediate was dissolved in DMSO (1 mL), and 35 mg of acid-6 was added (the acid was purchased commercially, or the preparation of the acid please refer to: CN 105121432 A, J. Med. Chem. 2017, 60, 1247 ), HATU (56mg), DIPEA (60 mg), the reaction was overnight, added water and ethyl acetate extraction, the organic layer was collected, dried over anhydrous sodium sulfate, vacuum rotary evaporation to remove the solvent, HPLC separation to obtain compound ZB-R-24.

The synthetic route of 138624-97-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Zhou Bing; Tang Wei; Yang Xiangbo; Lu Huimin; Gao Mengying; Yang Yaxi; Feng Huijin; (69 pag.)CN111138448; (2020); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Electric Literature of 138624-97-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 138624-97-2, name is 1-Benzyl-1H-1,2,4-triazole-3-carboxylic acid belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below.

A mixture of (3S)-3-amino- 1 ,8-dimethyl-4,5-dihydro-3H-pyrido[3,4-b] azepine-2,7- dione (15 mg, 0.07 mmol), 1- (3-dimethylaminopropyl) -3-ethylcarbodiimidehydrochloride (16 mg, 0.08 mmol), i-hydroxybenzotriazole (ii mg, 0.08 mmol) and i-benzyl-i,2,4- triazole-3-carboxylic acid (17 mg, 0.08 mmol) in N,N-dimethylformamide (3 mL) was stirredat 25 C for 2 h. The mixture was concentrated under reduced pressure and the residue was purified by RP-HPLC (acetonitrile 20-50%/0.05% ammonium hydroxide in water) to afford arbitrarily assigned (S)- 1 -benzyl-N-( 1 ,8-dimethyl-2,7-dioxo-2,3,4,5,7,8-hexahydro- 1H- pyrido[3,4-b]azepin-3-yl)-1H-i,2,4-triazole-3-carboxamide (22.2 mg, 78%) as a white solid. ?H NMR (400 MHz, CD3OD) 8.56 (s, 1H), 7.87 (s, 1H), 7.37 – 7.33 (m, 5H), 6.49 (s, 1H),5.46 (s, 2H), 4.71 – 4.65 (m, 1H), 3.59 (s, 3H), 3.32 (s, 3H), 2.74 – 2.68 (m, 2H), 2.45 – 2.38 (m, 1H), 2.13 – 2.08 (m, 1H). LCMS RT = 0.697 mm, m/z = 407.1 [M + H]. LCMS (5 to 95% acetonitrile in water + 0.1% formic acid over 1.5 mins) retention time 0.697 mi ESI+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Benzyl-1H-1,2,4-triazole-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; PATEL, Snahel; (105 pag.)WO2018/73193; (2018); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 138624-97-2, name is 1-Benzyl-1H-1,2,4-triazole-3-carboxylic acid, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 138624-97-2, Recommanded Product: 138624-97-2

M-10 (25 mg) was dissolved in 2 mL of dichloromethane and 1 mL of trifluoroacetic acid, and after 1 hour of reaction, the solvent was spin-dried to obtain the intermediate amine. Subsequently, the intermediate was dissolved in DMSO (1 mL), and 35 mg of acid-6 was added (the acid was purchased commercially, or the preparation of the acid please refer to: CN 105121432 A, J. Med. Chem. 2017, 60, 1247 ), HATU (56mg), DIPEA (60mg), the reaction was overnight, added water and ethyl acetate extraction, the organic layer was collected, dried over anhydrous sodium sulfate, vacuum rotary evaporation to remove the solvent, HPLC separation to obtain compound ZB-R-5.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Zhou Bing; Tang Wei; Yang Xiangbo; Lu Huimin; Gao Mengying; Yang Yaxi; Feng Huijin; (69 pag.)CN111138448; (2020); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Related Products of 138624-97-2, The chemical industry reduces the impact on the environment during synthesis 138624-97-2, name is 1-Benzyl-1H-1,2,4-triazole-3-carboxylic acid, I believe this compound will play a more active role in future production and life.

A mixture of (3S)-3-amino- 1 ,7-dimethyl-4,5-dihydro-3H-pyrido [4,3-b] azepine-2,8- dione (15 mg, 0.07 mmol), i-hydroxybenzotriazole (ii mg, 0.08 mmol), i-(3-dimethylaminopropyl)-3-ethylcarbodiimidehydrochloride (16 mg, 0.08 mmol) and 1 -benzyli,2,4-triazole-3-carboxylic acid (17 mg, 0.08 mmol) in N,N-dimethylformamide (3 mL) was stirred at 25 C for 2 h. The solvent was removed under reduced pressure. The residue was purified by HPLC reverse phase chromatography (acetonitrile 17-47% / 0.05% NH4OH in water) to afford arbitrarily assigned 1 -benzyl-N- [(3S)- 1 ,7-dimethyl-2,8 -dioxo-4,5-dihydro-3H-pyrido[4,3-b]azepin-3-yl]-i,2,4-triazole-3-carboxamide (i6.6 mg, 60%) as a white solid.?H NMR (400 MHz, CD3OD) oe 8.57 (s, iH), 7.63 (s, iH), 7.38 – 7.32 (m, 5H), 6.46 (s, iH),5.47 (s, 2H), 4.64 – 4.59 (m, 1H), 3.57 (s, 3H), 3.36 (s, 3H), 2.67 – 2.61 (m, 2H), 2.45 – 2.41(m, 1H), 2.10 – 2.06 (m, 1H). LCMS RT = 0.582 mm, m/z = 407.1 [M + H]. LCMS (5 to95% acetonitrile in water + 0.1% formic acid over 1.5 mins) retention time 0.5 82 mi ESI+found [M+H] = 407.1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Benzyl-1H-1,2,4-triazole-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; PATEL, Snahel; (105 pag.)WO2018/73193; (2018); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Electric Literature of 138624-97-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 138624-97-2, name is 1-Benzyl-1H-1,2,4-triazole-3-carboxylic acid belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 1-benzyl-1,2,4-triazole-3-carboxylic acid (16 mg, 0.08 mmol), (6S)-6-amino-2,4-dimethyl-7,8-dihydro-6H-pyrazolo[4,3-b]azepin-5-one (15 mg, 0.08 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimidehydrochloride (15 mg, 0.08 mmol) and 1-hydroxybenzotriazole (10 mg, 0.08 mmol) in N,N-dimethylformamide (5 mL) was stirred at 30 C. for 2 h. The mixture was concentrated under reduce pressure. The residue was purified by RP-HPLC (acetonitrile 22-50%/0.05% hydrochloride acid in water) to afford 1-benzyl-N-[(6S)-2,4-dimethyl-5-oxo-7,8-dihydro-6H-pyrazolo[4,3-b]azepin-6-yl]-1,2,4-triazole-3-carboxamide (16.3 mg, 56%) as a white solid. 1H NMR (400 MHz, CD3OD) delta 8.81 (s, 1H), 7.84 (s, 1H), 7.38-7.33 (m, 5H), 5.51 (s, 2H), 4.73-4.68 (m, 1H), 3.93 (s, 3H), 3.31 (s, 3H), 3.00-2.90 (m, 2H), 2.50-2.45 (m, 1H), 2.27-2.22 (m, 1H). LCMS RT=1.088 min, m/z=380.2 [M+H]+. LCMS (5 to 95% acetonitrile in water+0.03% trifluoroacetic acid over 1.5 mins) retention time 1.088 min, ESI+ found [M+H]=380.2.

The synthetic route of 1-Benzyl-1H-1,2,4-triazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Genentech, Inc.; Patel, Snahel; Hamilton, Gregory; (73 pag.)US2018/170927; (2018); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

138624-97-2, name is 1-Benzyl-1H-1,2,4-triazole-3-carboxylic acid, belongs to Triazoles compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 138624-97-2

To a screw cap vial 6-amino-4-methyl-2-(trifluoromethyl)-7,8-dihydro-4H-pyrazolo[1,5-a][1,3]diazepin-5(6H)-one (74mg, 0.298 mmol), l-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (158 mg, 0.417 mmol), 1-benzyl-1H-1,2,4-triazole-3-carboxylic acid (76mg, 0.358 mmol) was added and dissolved in N,N-dimethylformamide (5 mL). To the reaction mixture was added trimethyl amine (0.166 mL, 1.19 mmol), the vial was capped and stirred at RT for 16 h. The mixture was concentrated to dryness in vacuo and the residue was purified by RP-HPLC affording 1-benzyl-N-(4-methyl-5-oxo-2-(trifluoromethyl)-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,3]diazepin-6-yl)-1H-1,2,4-triazole-3-carboxamide (77mg, 59% yield): 1H NMR (400 MHz, DMSO-d6) delta 8.82 (s, 1H), 8.63 (d, J = 7.6 Hz, 1H), 7.49 – 7.19 (m, 5H), 6.93 (s, 1H), 5.49 (s, 2H), 4.51 – 4.42 (m, 1H), 4.39 – 4.27 (m, 2H), 3.27 (s, 3H), 2.72 – 2.59 (m, 1H), 2.48 – 2.42 (m, 1H). LC-MS RT = 4.34 min, m/z = 434.1 (M+H) +. LCMS (2 to 98% acetonitrile in water + 0.1% formic acid over 10 mins) retention time 4.34 min, ESI+ found [M+H] = 434.1.

The synthetic route of 138624-97-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GENENTECH, INC.; F. HOFFMANN-LA ROCHE AG; PATEL, Snahel; HAMILTON, Gregory; STIVALA, Craig; CHEN, Huifen; ZHAO, Guiling; (1236 pag.)WO2017/4500; (2017); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 138624-97-2, name is 1-Benzyl-1H-1,2,4-triazole-3-carboxylic acid, A new synthetic method of this compound is introduced below., Quality Control of 1-Benzyl-1H-1,2,4-triazole-3-carboxylic acid

A mixture of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimidehydrochloride (35 mg, 0.18 mmol), 6-amino-4-methyl-2-(tetrahydrofuran-3-ylmethyl)-7,8-dihydro-6H-pyrazolo[1,5-a][1,3]diazepin-5-one (40 mg, 0.15 mmol), 1-hydroxybenzotriazole (25 mg, 0.18 mmol) and 1-benzyl-1,2,4-triazole-3-carboxylic acid (34 mg, 0.17 mmol) in N,N-dimethylformamide (3 mL) was stirred at 25 C. for 12 h. The reaction mixture was concentrated under reduced pressure. The residue was purified by RP-HPLC (methanol 40%-70%/0.05% ammonia hydroxide in water) to afford 1-benzyl-N-[4-methyl-5-oxo-2-(tetrahydrofuran-3-ylmethyl)-7,8-dihydro-6H-pyrazolo[1,5-a][1,3]diazepin-6-yl]-1,2,4-triazole-3-carboxamide (30 mg, 43%) as a white solid.

The synthetic route of 138624-97-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Genentech, Inc.; Patel, Snahel; Hamilton, Gregory; (73 pag.)US2018/170927; (2018); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics