Category: 143426-50-0

Synthetic Route of 143426-50-0, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 143426-50-0, name is 4-(1,2,4-Triazol-1-yl)benzyl Alcohol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of (4-(1 H-1 ,2,4-triazol-1-yl)phenyl)methanol (133 mg, 0.76 mmol) in dry DCM (2 mL), SOCI2 (0.1 mL, 1.52 mol) was added at 0 C and the resulting mixture was stirred for 3 h at RT. The completion of the reaction was monitored by TLC. The reaction mixture was concentrated under vacuum and the resulting product was co-distilled with DCM (2 x 10 mL) to get the title compound that was used without any further purification. Yield: 60% (1 10 mg, pale yellow solid). 1H NMR (400 MHz, DMSO -cfe): d 9.33 (s, 1 H), 8.26 (s, 1 H), 7.89 (d, 8.8 Hz, 2H), 7.64 (d, J = 8.8 Hz, 2H), 4.85 (s, 2H). LCMS: (Method A) 194.1 (M+H), Rt.1.73 min, 79.10% (Max).

By the way, if you are interested in learning more fun chemistry with your kids, get your hands into one chemistry set now, and start enjoying the best part of chemistry: experiments about 4-(1,2,4-Triazol-1-yl)benzyl Alcohol.

Reference:
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; WISHART, Grant; KULKARNI, Santosh S.; RAKESH, Paul; (338 pag.)WO2020/39027; (2020); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Reference of 143426-50-0, New Advances in Chemical Research in 2021.In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 143426-50-0, name is 4-(1,2,4-Triazol-1-yl)benzyl Alcohol, molecular formula is C9H9N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

General procedure: To a 25-mL Schlenk tube equipped with a magnetic stirrer, PdCl2(CH3CN)2 (0.05mol, 5mol%), Bi(OTf)3 (0.05mol, 5mol%), K2CO3 (1mmol) were added. Substrates 1 (1mmol) and MeOH (2mL) were added subsequently. The reaction tube was vacuumed and backfilled with oxygen (3 times). Then the reaction mixture was stirred at 60C for 3h in the presence of an oxygen balloon. The progress of the reaction was monitored by TLC. After completion, the reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate. Subsequently, the combined organic layer was concentrated under reduced pressure and the crude product was purified by column chromatography with hexane/ethyl acetate to afford the corresponding products 2.

We very much hope you enjoy reading the articles and that you will join us to present your own research about 143426-50-0, Happy reading!

Reference:
Article; Hu, Yongke; Li, Bindong; Tetrahedron; vol. 73; 52; (2017); p. 7301 – 7307;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Research speed reading in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 143426-50-0, name is 4-(1,2,4-Triazol-1-yl)benzyl Alcohol belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. category: Triazoles

A mixture of 14 (100 mg, 0.34 mmol), [4-(1H-1,2,4-triazol-1-yl)phenyl]methanol16 (118 mg, 0.67 mmol)and (tributylphosphoranylidene)acetonitrile (163 mg, 0.68 mmol) in toluene (2 mL) wasstirred at 100 C for 1.5 h and allowed to cool to room temperature. Themixture was evaporated in vacuo and the crude mixture was purifiedusing amino-functionalized silica-gel column chromatography (CHCl3)and washed with diisopropyl ether to give N-ethyl-5-(2-methyl-8-{[4-(1H-1,2,4-triazol-1-yl)phenyl]methoxy}imidazo[1,2-a]pyridin-3-yl)pyridine-2-carboxamide (87 mg). Next, 4M HCl in EtOAc (0.20 mL,0.80 mmol) was added to a 2.2 mL EtOAc-EtOH (10:1) solution of thiscompound. After stirring at room temperature, the precipitate was filteredto give the product as a beige solid (87 mg, 49% yield [2 steps]).1H NMR (DMSO-d6) delta ppm 1.16 (3H, t, J=7.1 Hz), 2.50 (3H, s),3.33-3.43 (2H, m), 5.59 (2H, s), 7.39 (1H, dd, J=8.0, 6.9 Hz), 7.63(1H, d, J=8.2 Hz), 7.80-7.85 (2H, m), 7.94-7.99 (2H, m), 8.24-8.32(4H, m), 8.88 (1H, dd, J=2.0, 1.0 Hz), 8.96 (1H, t, J=6.1 Hz), 9.37(1H, s); MS (ESI) m/z [M+H]+ 454. HRMS (ESI) m/z calcd forC25H24N7O2 ([M+H]+): 454.1986. Found: 454.1989. Anal. calcd forC25H23N7O21.5HCl·2.3H2O0.15EtOAc: C, 54.63; H, 5.43; N, 17.42;Cl, 9.45. Found: C, 54.87; H, 5.32; N, 17.72; Cl, 9.10.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 143426-50-0, and we look forward to future research findings.

Reference:
Article; Sekioka, Ryuichi; Honda, Shugo; Honjo, Eriko; Suzuki, Takayuki; Akashiba, Hiroki; Mitani, Yasuyuki; Yamasaki, Shingo; Bioorganic and Medicinal Chemistry; vol. 28; 1; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Electric Literature of 143426-50-0, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 143426-50-0, name is 4-(1,2,4-Triazol-1-yl)benzyl Alcohol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of (4-(1 H-1 ,2,4-triazol-1-yl)phenyl)methanol (133 mg, 0.76 mmol) in dry DCM (2 mL), SOCI2 (0.1 mL, 1.52 mol) was added at 0 C and the resulting mixture was stirred for 3 h at RT. The completion of the reaction was monitored by TLC. The reaction mixture was concentrated under vacuum and the resulting product was co-distilled with DCM (2 x 10 mL) to get the title compound that was used without any further purification. Yield: 60% (1 10 mg, pale yellow solid). 1H NMR (400 MHz, DMSO -cfe): d 9.33 (s, 1 H), 8.26 (s, 1 H), 7.89 (d, 8.8 Hz, 2H), 7.64 (d, J = 8.8 Hz, 2H), 4.85 (s, 2H). LCMS: (Method A) 194.1 (M+H), Rt.1.73 min, 79.10% (Max).

By the way, if you are interested in learning more fun chemistry with your kids, get your hands into one chemistry set now, and start enjoying the best part of chemistry: experiments about 4-(1,2,4-Triazol-1-yl)benzyl Alcohol.

Reference:
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; WISHART, Grant; KULKARNI, Santosh S.; RAKESH, Paul; (338 pag.)WO2020/39027; (2020); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 143426-50-0, name is 4-(1,2,4-Triazol-1-yl)benzyl Alcohol, belongs to triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 143426-50-0, COA of Formula: C9H9N3O

A mixture of 14 (100 mg, 0.34 mmol), [4-(1H-1,2,4-triazol-1-yl)phenyl]methanol16 (118 mg, 0.67 mmol)and (tributylphosphoranylidene)acetonitrile (163 mg, 0.68 mmol) in toluene (2 mL) wasstirred at 100 C for 1.5 h and allowed to cool to room temperature. Themixture was evaporated in vacuo and the crude mixture was purifiedusing amino-functionalized silica-gel column chromatography (CHCl3)and washed with diisopropyl ether to give N-ethyl-5-(2-methyl-8-{[4-(1H-1,2,4-triazol-1-yl)phenyl]methoxy}imidazo[1,2-a]pyridin-3-yl)pyridine-2-carboxamide (87 mg). Next, 4M HCl in EtOAc (0.20 mL,0.80 mmol) was added to a 2.2 mL EtOAc-EtOH (10:1) solution of thiscompound. After stirring at room temperature, the precipitate was filteredto give the product as a beige solid (87 mg, 49% yield [2 steps]).1H NMR (DMSO-d6) delta ppm 1.16 (3H, t, J=7.1 Hz), 2.50 (3H, s),3.33-3.43 (2H, m), 5.59 (2H, s), 7.39 (1H, dd, J=8.0, 6.9 Hz), 7.63(1H, d, J=8.2 Hz), 7.80-7.85 (2H, m), 7.94-7.99 (2H, m), 8.24-8.32(4H, m), 8.88 (1H, dd, J=2.0, 1.0 Hz), 8.96 (1H, t, J=6.1 Hz), 9.37(1H, s); MS (ESI) m/z [M+H]+ 454. HRMS (ESI) m/z calcd forC25H24N7O2 ([M+H]+): 454.1986. Found: 454.1989. Anal. calcd forC25H23N7O21.5HCl¡¤2.3H2O0.15EtOAc: C, 54.63; H, 5.43; N, 17.42;Cl, 9.45. Found: C, 54.87; H, 5.32; N, 17.72; Cl, 9.10.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-(1,2,4-Triazol-1-yl)benzyl Alcohol, and friends who are interested can also refer to it.

Reference:
Article; Sekioka, Ryuichi; Honda, Shugo; Honjo, Eriko; Suzuki, Takayuki; Akashiba, Hiroki; Mitani, Yasuyuki; Yamasaki, Shingo; Bioorganic and Medicinal Chemistry; vol. 28; 1; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthetic Route of 143426-50-0,Some common heterocyclic compound, 143426-50-0, name is 4-(1,2,4-Triazol-1-yl)benzyl Alcohol, molecular formula is C9H9N3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of (4-(1 H-1 ,2,4-triazol-1-yl)phenyl)methanol (133 mg, 0.76 mmol) in dry DCM (2 mL), SOCI2 (0.1 mL, 1.52 mol) was added at 0 C and the resulting mixture was stirred for 3 h at RT. The completion of the reaction was monitored by TLC. The reaction mixture was concentrated under vacuum and the resulting product was co-distilled with DCM (2 x 10 mL) to get the title compound that was used without any further purification. Yield: 60% (1 10 mg, pale yellow solid). 1H NMR (400 MHz, DMSO -cfe): d 9.33 (s, 1 H), 8.26 (s, 1 H), 7.89 (d, 8.8 Hz, 2H), 7.64 (d, J = 8.8 Hz, 2H), 4.85 (s, 2H). LCMS: (Method A) 194.1 (M+H), Rt.1.73 min, 79.10% (Max).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(1,2,4-Triazol-1-yl)benzyl Alcohol, its application will become more common.

Reference:
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; WISHART, Grant; KULKARNI, Santosh S.; RAKESH, Paul; (338 pag.)WO2020/39027; (2020); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 143426-50-0, name is 4-(1,2,4-Triazol-1-yl)benzyl Alcohol, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C9H9N3O

General procedure: To a 25-mL Schlenk tube equipped with a magnetic stirrer, CuCl (0.05 mol, 5 mol%), DABCO (0.10 mol, 10 mol%), 4-HO-TEMPO (0.05 mmol, 5 mol%) were added. Substrates 1 (1 mmol) and NH3 (aq, 25-28%, 3 mmol, 3.0 equiv) in CH3CN (2 mL) were added subsequently. Then the reaction mixture was stirred at room temperature for 24 h in the presence of an air balloon. The progress of the reaction was monitored by TLC. After completion, the reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was dried over anhydrous MgSO4. Subsequently, the combined organic layer was concentrated under reduced pressure and the crude product was purified by column chromatography to afford the corresponding products.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 143426-50-0.

Reference:
Article; Hu, Yongke; Chen, Lei; Li, Bindong; Chinese Chemical Letters; vol. 29; 3; (2018); p. 464 – 466;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Reference of 143426-50-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 143426-50-0, name is 4-(1,2,4-Triazol-1-yl)benzyl Alcohol belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a 25-mL Schlenk tube equipped with a magnetic stirrer, PdCl2(CH3CN)2 (0.05mol, 5mol%), Bi(OTf)3 (0.05mol, 5mol%), K2CO3 (1mmol) were added. Substrates 1 (1mmol) and MeOH (2mL) were added subsequently. The reaction tube was vacuumed and backfilled with oxygen (3 times). Then the reaction mixture was stirred at 60C for 3h in the presence of an oxygen balloon. The progress of the reaction was monitored by TLC. After completion, the reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate. Subsequently, the combined organic layer was concentrated under reduced pressure and the crude product was purified by column chromatography with hexane/ethyl acetate to afford the corresponding products 2.

The synthetic route of 4-(1,2,4-Triazol-1-yl)benzyl Alcohol has been constantly updated, and we look forward to future research findings.

Reference:
Article; Hu, Yongke; Li, Bindong; Tetrahedron; vol. 73; 52; (2017); p. 7301 – 7307;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics