Category: 1455-77-2

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1455-77-2, name is 3,5-Diamino-1,2,4-triazole, A new synthetic method of this compound is introduced below., category: Triazoles

In a 500 mL round-bottomed flask, lH-l,2,4-triazole-3,5-diamine (1.5 g, 15.1 mmol, Eq: 1.00) and sodium methoxide 1M (33.3 ml, 16.7 mmol, Eq: 1.1) were combined with MeOH (100 ml) to give a colorless turbid solution. The reaction mixture was stirred for 4 hr and stripped to a gray solid. Suspended in 30 ml DMF and l-(chloromethyl)-4-methoxybenzene (2.42 g, 2.1 ml, 15.4 mmol, Eq: 1.02) was added. The dark brown suspension was stirred at 25C for 60 hrs under argon. The reaction was diluted with water (35 ml) and extracted with EtOAc (3 x 50 ml). The organic layers were combined, washed with H20 (1 x 25 mL), sat NaCl (1 x 50 ml), dried over Na2S04 and concentrated in vacuo to a white pasty solid. Dried under vacuum while gently heating to remove residual DMF and PMB-C1. The crude material was purified by flash chromatography (silica gel, 80g, 0percent to 10percent MeOH in DCM) to give 457 mg of desired product as a yellow solid (14percent). MS (m+1) = 220.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; CHEN, Zhi; CHIN, Elbert; ERICKSON, Shawn David; GABRIEL, Stephen Deems; MERTZ, Eric; WEIKERT, Robert James; WO2014/135483; (2014); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application of 1455-77-2,Some common heterocyclic compound, 1455-77-2, name is 3,5-Diamino-1,2,4-triazole, molecular formula is C2H5N5, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of 10 mmol of 1,2,4-triazole-3,5-diamine, pyridine-2,6-diamine, or 4-hydroxypyrimidine-2,6-diamine in 50 mL of glacial acetic acid was slowly added to a solution of 20 mmol of phthalic anhydride or tetrachlorophthalic anhydride in 100 mL of glacial acetic acid. The colored solution was refluxed with constant stirring for 8 h at 100 ¡ãC (TLC monitoring; MeOH?CH2Cl2, 1 : 4) and poured into cold water. The colored precipitate was filtered off, dried in a vacuum desiccator over fused CaCl2, and recrystallized from DMSO. 2,2?-(1H-1,2,4-Triazole-3,5-diyl)bis[1H-isoindole-1,3(2H)-dione] (1). Yield 66percent, white solid, mp >300¡ãC. IR spectrum, nu, cm?1: 1793, 1743 (C=O), 3298 (N?H),691 [delta(C?Carom)]. 1H NMR spectrum, delta, ppm: 7.60 d (4H, Harom), 7.69 d (4H, Harom), 11.13 s (1H, NH). Mass spectrum: m/z 360.01 [M + 1]+. Found, percent: C60.12; H 2.47; N 19.54. C18H9N5O4. Calculated, percent: C60.17; H 2.52; N 19.49.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,5-Diamino-1,2,4-triazole, its application will become more common.

Reference:
Article; Arif; Nayab, P. Sirajuddin; Rahisuddin; Russian Journal of General Chemistry; vol. 86; 6; (2016); p. 1374 – 1380; Zh. Obshch. Khim.; vol. 86; 6; (2016); p. 1374 – 1380,7;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthetic Route of 1455-77-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1455-77-2, name is 3,5-Diamino-1,2,4-triazole, This compound has unique chemical properties. The synthetic route is as follows.

4′-methoxy acetophenone was used in place of 2-acetylthiophene in Reference Example 001 and heated to reflux in xylene in the presence of N,N-dimethylformamide diethyl acetal as in Reference Example 001, and 3-dimethylamino-1-(4-methoxyphenyl)propenone (yield 99percent) was obtained, which was subsequently reacted with 3,5-diamino-1,2,4-triazole in toluene in the presence of 10-camphor sulfonic acid and the title compound was obtained (yield 61percent).

The chemical industry reduces the impact on the environment during synthesis 3,5-Diamino-1,2,4-triazole. I believe this compound will play a more active role in future production and life.

Reference:
Patent; NIPPON KAYAKU KABUSHIKI KAISHA; EP1674454; (2006); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 1455-77-2, name is 3,5-Diamino-1,2,4-triazole, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1455-77-2, HPLC of Formula: C2H5N5

A solution of 9.0 g 3,5-diamino-1,2,4-triazole and 22.4 ml diethyl phenylmalonate in N,N-dibutylbutan-1-amine is heated under microwave irradiation to 180¡ã C. for 8 h. The reaction mixture forms two layers after cooling to room temperature. The top layer is removed and the solvent of the lower layer is evaporated. The residue is treated with water and acidified with 5N HCl. The precipitated product is collected by filtration and dried. The crude product is used without further purification.MS (M+1): 244

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Holder, Swen; Vennemann, Matthias; Beneke, Gerrit; Zulch, Armin; Gekeler, Volker; Beckers, Thomas; Zimmermann, Astrid; Joshi, Hemant; US2009/137607; (2009); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

1455-77-2, name is 3,5-Diamino-1,2,4-triazole, belongs to Triazoles compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C2H5N5

Example 243: Preparation of 6-((4-((3-amino-lH-l,2,4-triazol-5-yl)amino)-5-(trifluoro methyl)pyrimidin-2-yI)amino)-3,4-dihydroquinolin-2(lH)-one6-((4-Chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroquinolin-2(lH)-one (0.072 g, 0.210 mmol), lH-l ,2,4-triazole-3,5-diamine (0.021 g, 0.210 mmol) and -ethyl-N- isopropylpropan-2-amine (0.037 ml, 0.210 mmol) were mixed in DMF (2 ml). The mixture was microwaved at 1 10 ¡ãC for 20 min. Added copper (6.68 mg, 0.105 mmol) and more base and the mixture was microwaved at 130 ¡ãC for 20 min and then concentrated. 7 mg of product was recovered after automated reverse phase chromatography (water-3percent DMF in MeCN eluent). MS calcd for [C16Hi4F3N90+H]+: 406.14, found 406.10.

The synthetic route of 1455-77-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE; YALE UNIVERSITY; SHAW, Reuben J.; EGAN, Daniel F.; COSFORD, Nicholas; TURK, Benjamin; VAMOS, Mitchell; PANICKAR, Dhanya Raveendra; CHUN, Matthew; SHEFFLER, Doug; (315 pag.)WO2016/33100; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Electric Literature of 1455-77-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1455-77-2, name is 3,5-Diamino-1,2,4-triazole belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A solution of 10 mmol of 1,2,4-triazole-3,5-diamine, pyridine-2,6-diamine, or 4-hydroxypyrimidine-2,6-diamine in 50 mL of glacial acetic acid was slowly added to a solution of 20 mmol of phthalic anhydride or tetrachlorophthalic anhydride in 100 mL of glacial acetic acid. The colored solution was refluxed with constant stirring for 8 h at 100 ¡ãC (TLC monitoring; MeOH?CH2Cl2, 1 : 4) and poured into cold water. The colored precipitate was filtered off, dried in a vacuum desiccator over fused CaCl2, and recrystallized from DMSO.

The synthetic route of 3,5-Diamino-1,2,4-triazole has been constantly updated, and we look forward to future research findings.

Reference:
Article; Arif; Nayab, P. Sirajuddin; Rahisuddin; Russian Journal of General Chemistry; vol. 86; 6; (2016); p. 1374 – 1380; Zh. Obshch. Khim.; vol. 86; 6; (2016); p. 1374 – 1380,7;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthetic Route of 1455-77-2,Some common heterocyclic compound, 1455-77-2, name is 3,5-Diamino-1,2,4-triazole, molecular formula is C2H5N5, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A suspension of 3,5-diamino-1,2,4-triazole (0.1 g, 1 mmol) in absolute EtOH (10 mL) was added to a stirring solution of azo-coupled precursors, Ia-IVa, (2 mmol) in absolute EtOH (50 mL) during a period of 10 min at 60-70 ¡ãC. The mixture was heated in water bath for 15 h at 80 ¡ãC with stirring. The mixture was filtered whilst hot and the obtained solid was washed with hot ethanol (three time) and then with diethylether. The resulted product was dried in air.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,5-Diamino-1,2,4-triazole, its application will become more common.

Reference:
Article; Khanmohammadi, Hamid; Erfantalab, Malihe; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 86; (2012); p. 39 – 43;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Some common heterocyclic compound, 1455-77-2, name is 3,5-Diamino-1,2,4-triazole, molecular formula is C2H5N5, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C2H5N5

3-Amino-6-chloro-1,2,4,5-tetrazine (4) (1:00 g, 7.60mmol) was dissolved in a mixture of 16:0 mL acetonitrile and 2:0 mL water. To the stirred solution 3,5-diamino-1,2,4-triazole (1:51 g, 15:2 mmol) was added. The mixturewas heated to 90 ¡ãC and refluxed for 16 h. The precipitatewas filtered and washed with water and acetonitrile. Theproduct (9) was recrystallized from water. After standing overnight at ambient temperature, the crystals were filteredand dried. 1:33 g (5:78 mmol; 76percent) of red needles of 9 were yielded. ? Elemental analysis (C4H10N10O2, 230.19)exp. (calcd.) in percent: C 20.62 (20.87); H 4.18 (4.38); N 60.37(60.85). ? DSC (5 C min1, ¡ã C): Tdec:: c 314 ¡ãC. ? 1H NMR([D6]DMSO, 25 ¡ãC, ppm): d =5.38 (s, 2H, NH2 triazole),6.94 (s, 2H, NH2 triazole), 7.83 (s, 2H, NH2 tetrazine).? 13C NMR ([D6]DMSO, 25 ¡ãC, ppm): d =155.5 (1C,C-NH2 triazole), 156.3 (1C, C-NH2 triazole), 162.7 (1C,C-tetrazine), 162.9 (1C, C-tetrazine). ? MS ((+)-DEI): m=z = 194.1 (100) [C4H6N10]+, 124.1 (43) [C3H4N6]+,99.1 (5) [C2H5N2]+, 82.1 (19) [C2H2N5]+. ? Raman: n(cm-1)=3250 (2), 3184 (5), 1648 (7), 1570 (5), 1555 (12), 1526 (5), 1477 (90), 1399 (4), 1371 (8), 1335 (6), 1158 (10),1027 (18), 866 (100), 828 (4), 669 (7), 580 (9), 456 (5), 356(4), 345 (7), 321 (6). ? Sensitivity data: IS: > 40 J; FS: >360 N; ESD: > 1 J.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1455-77-2, its application will become more common.

Reference:
Article; Klapoetke, Thomas M.; Preimesser, Andreas; Stierstorfer, Joerg; Zeitschrift fur Naturforschung, B: Chemical Sciences; vol. 68; 12; (2013); p. 1310 – 1320;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1455-77-2, name is 3,5-Diamino-1,2,4-triazole, A new synthetic method of this compound is introduced below., COA of Formula: C2H5N5

Included at room temperature3,5-diamino-1,2,4-triazole 15.6 g (0.157 mol)And dehydrated N,N-dimethylformamide 100mLAdd 53.5 g (0.157 mol) of 20percent sodium ethoxide ethanol solution to the suspension.After heating to 55~60 ¡ã C and stirring for 20 minutes,37.9 g (0.157 mol) of 3-chloropropyltriethoxydecane was added.Stir at 87~90 ¡ã C for 6 hours.After cooling the suspension reaction solution to 3 ¡ã C,Filter out insoluble matter,And the solvent of the filtrate is distilled off under reduced pressure,Obtained 42.3 g of brown viscous material (0.139 mol,Yield 88.8percent).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; SHIKOKU CHEMICALS CORPORATION; MURAI,, TAKAYUKI; TANIOKA, MIYA; IIDA, SHUSAKU; KATSUMURA, MASATO; YAMAJI, NORIAKI; IMAMINE, TAKAHITO; TSUJINO, MASAHIKO; HIRAO, HIROHIKO; (52 pag.)TW2018/41929; (2018); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 1455-77-2, name is 3,5-Diamino-1,2,4-triazole, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1455-77-2, Application In Synthesis of 3,5-Diamino-1,2,4-triazole

The specific steps are as follows: 4 (3.34 g, 10 mmol) is dissolved in a mixture of methanol (10 ml) and acetonitrile (10 ml) at room temperature.Add two equivalents of an aqueous solution of 3,5-diamino-1,2,4-triazole for 2 h.Solid precipitated, filtered, washed with acetonitrile,The target product was obtained in a yield of 88.6percent.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Diamino-1,2,4-triazole, and friends who are interested can also refer to it.

Reference:
Patent; Nanjing University of Science and Technology; Lin Qiuhan; Sun Qi; Lu Ming; Wang Pengcheng; (9 pag.)CN108689959; (2018); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics