Category: 1455-77-2

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1455-77-2, name is 3,5-Diamino-1,2,4-triazole, A new synthetic method of this compound is introduced below., Quality Control of 3,5-Diamino-1,2,4-triazole

Intermediate Example 36.0: 4-(2-Bromo-6-phenyl[1,2,4]triazolo[1,5- a]pyrimidin-5-yl)benzaldehyde; Stepi : 2-Amino-6-phenyl[1 ,2,4]triazolo[1 ,5-a]pyrimidine-5,7-diol; A solution of 9.Og 3,5-diamino-1 ,2,4-triazole and 22.4mL diethyl phenylmalonate in N,N-dibutylbutan-1-amine was heated under microwave irradiation to 1800C for 8h. The reaction mixture formed two layers after cooling to room temperature. The top layer was removed and the solvent of the lower layer was evaporated. The residue was treated with water and acidified with 5N HCI. The precipitated product was collected by filtration and dried. The crude product was used without further purification. MS (M+1): 244

The synthetic route of 1455-77-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; VENNEMANN, Matthias; MAIER, Thomas; HOeLDER, Swen; BENEKE, Gerrit; DEHMEL, Florian; ZUeLCH, Armin; STRUB, Andreas; BECKERS, Thomas; INCE, Stuart; REHWINKEL, Hartmut; LIU, Ningshu; BOeMER, Ulf; WO2010/91808; (2010); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Reference of 1455-77-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1455-77-2, name is 3,5-Diamino-1,2,4-triazole, This compound has unique chemical properties. The synthetic route is as follows.

3,5-Diamino-1,2,4-triazole (151.7 mg, 1.5 mmol) in ethanol(10 mL) was added to a solution containing 2-hydroxy-1-naphthalehyde (298.7 mg, 1.7 mmol) in ethanol (10 mL).The reaction mixture was stirred for 1 d, until the yellow precipitate appeared. The precipitate was filtered and washed with ether (10 mL¡Á2) and ethanol (10 mL). The yield was 69 percent (262.1 mg). 1H NMR (400 MHz, DMSO-d6, ppm) delta12.13 (s, 1H), 9.84 (s, 1H), 8.21 (d, J=8.7 Hz, 1H), 8.00 (d,J=9.2 Hz, 1H), 7.87 (d, J=8.1 Hz, 1H), 7.60 (t, J=7.7 Hz,1H), 7.41 (t, J=7.5 Hz, 1H), 7.13 (d, J=9.1 Hz, 1H), 6.30 (s,2H); 13C NMR (100 MHz, DMSO-d6, ppm): 166.36 (1C),160.37 (1C), 157.71 (1C), 157.30 (1C), 136.61 (1C), 133.02(1C), 129.66 (1C), 128.89 (1C), 127.64 (1C), 124.18 (1C),120.89 (1C), 120.03 (1C), 108.95 (1C). LRMS (ESI): m/zcalcd for C13H10N5O: 252.089 ([M-H+]); found, 252.267.Anal. calcd for C13H11N5O (249.273): C, 61.65; H, 4.38; N,27.65; found: C, 61.75; H, 4.39; N, 27.93.

The chemical industry reduces the impact on the environment during synthesis 3,5-Diamino-1,2,4-triazole. I believe this compound will play a more active role in future production and life.

Reference:
Article; Lee, Jae Jun; Lee, Sun Young; Bok, Kwon Hee; Kim, Cheal; Journal of Fluorescence; vol. 25; 5; (2015); p. 1449 – 1459;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 1455-77-2, name is 3,5-Diamino-1,2,4-triazole, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1455-77-2, SDS of cas: 1455-77-2

Example 9A(rac)-2-Amino-7-[4-cyano-2-(methylsulfonyl)phenyl]-5-methyl-4,7-dihydro[1,2,4]triazolo[1,5-a]-pyrimidine-6-carbonitrileUnder argon, 4-(2-cyano-3-oxobut-1-en-1-yl)-3-(methylsulfonyflbenzonitrile (1.0 g, 3.65 mmol), 3,5-diaminotriazole (1.08 g, 10.94 mmol, 3.0 eq.), D,L-proline (214 mg, 2.55 mmol, 0.7 eq.) and molecular sieve (4 A, 0.5 g) were suspended in a mixture of pyridine (20 ml) and DMF (30 ml) and stirred for 3 d.More 3,5-diaminotriazole (361 mg, 3.64 mmol, 1 eq.) was added, and the mixture was stirred for a further 5 d.The reaction mixture was then filtered and the filtrate was concentrated under reduced pressure (intermediate 4-[2-cyano-1-(3,5-diamino-1H-1,2,4-triazol-1-yl)-3-oxobutyl]-3-(methylsulfonyl)benzonitrile).Toluene (68 ml), pyridine (55 ml) and 4-toluenesulfonic acid monohydrate (100 mg, 0.53 mmol, 0.14 eq.) were added to the intermediate, and the mixture was heated under reflux (1 h).The reaction mixture was then concentrated under reduced pressure and the residue was dried under high vacuum.Ethanol (30 ml) was added, the residue was suspended and stirred in an ultrasonic bath and the solid was then filtered off and finally dried under high vacuum.This gave 673 mg (50percent of theory) of the title compound.LC-MS (Method 7): Rt=1.00 min; MS (ESIpos): m/z (percent)=356.1 (100) [M+H]+; MS (ESIneg): m/z (percent)=354.2 (100) [M-H]-.1H-NMR (400 MHz, DMSO-d6): delta=2.15 (s, 3H), 3.55 (s, 3H), 5.40 (m, 2H), 7.05 (s, 1H), 7.75 (m, 1H), 8.25 (m, 1H), 8.35 (s, 1H), 11.05 (s, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Diamino-1,2,4-triazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; US2012/4203; (2012); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application of 1455-77-2,Some common heterocyclic compound, 1455-77-2, name is 3,5-Diamino-1,2,4-triazole, molecular formula is C2H5N5, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of Hdatrz (9.9mg, 0.1mmol), NO2-H2ip (21.1mg, 0.1mmol) and Co(NO3)2¡¤6H2O (14.5mg, 0.05mmol) was dissolved in doubly distilled water (15.0mL), and the initial pH of the reactant mixture was adjusted to ca. 6 by slow addition of triethylamine with constant stirring. The resulting mixture was then transferred into a Teflon-lined stainless steel vessel (23.0mL) and heated at 140¡ãC for 72h under autogenous pressure. After the mixture was cooled to room temperature at a rate of 3.2¡ãCh?1, pink block-shaped crystals suitable for X-ray analysis were obtained directly, washed with water and dried in air (Yield: 50percent, based on CoII salt). Anal. Calc. for C20H18Co2N12O14: C, 31.27; H, 2.36; N, 21.88. Found: C, 31.25; H, 2.37; N, 21.86percent. IR (KBr pellet, cm?1): 3422 (br), 3336 (w), 3270 (w), 3083 (w), 1620 (s), 1571 (s), 1533 (s), 1366 (s), 1348 (s), 1200 (w), 1102 (w), 1068 (w), 822 (w), 785 (w), 753 (w), 735 (m), 718 (s), 669 (w), 563 (w), 525 (w), 477 (w), 433 (w).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,5-Diamino-1,2,4-triazole, its application will become more common.

Reference:
Article; Zhao, Hong; Li, Hong-Xue; Liu, Zhong-Yi; Yang, En-Cui; Zhao, Xiao-Jun; Polyhedron; vol. 101; (2015); p. 29 – 36;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

A common compound: 1455-77-2, name is 3,5-Diamino-1,2,4-triazole, belongs to Triazoles compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 1455-77-2

To a methanolic solution (15mL) of 9 3,5-diamino-1,2,4-triazole (0.099g, 1mmol) an equimolar solution of 10 2-chlorobenzaldehyde (0.141g, 1mmol) was added and the mixture was first stirred at room temperature for 30min and then refluxed for 5?6h. The excess of solvent was removed by under reduced pressure using rotavapor and then washed with methanol and recrystallized from dichloromethane – methanol. The resulted product was dried under vacuum. The synthesis scheme alongwith atom number (for assignment only) of the schiff base is presented in Scheme 1 . 2.1.2 12 (E)-N3-(2-chlorobenzylidene)-1H-1,2,4-triazole-3,5-diamine Yield: 0.157g, 71percent; colour: light yellow; m.p: 235?240¡ãC; 1H NMR (delta in ppm DMSO-d6, 500MHz): 12.10 (s, 1H, NHtriazole), 9.36 (s, 1H, H-7), 8.13 (d, 1H, J=7.5Hz, H-3), 7.53 (d, 1H, J=8Hz, H-4), 7.49 (d, 1H, J=8Hz, H-6), 7.43 (t, 1H, J=7.5Hz, H-5), 6.20 (s, 2H, NH2); 13C NMR (delta in ppm DMSO-d6/125MHz): 163.85 (C-8), 157.39 (C-7), 157.10 (C-9), 135.82 (C-2), 133.59 (C-1), 132.93 (C-3), 130.65 (C-6), 128.49 (C-4), 128.27 (C-5); FT-IR (KBr, cm?1): 3322 nuas(NH2), 3233 nu(N?H), 3149 nus(NH2), 2785 nu(C?H), 1651 nu(C=N), 681 nu(C?Cl); MS (ESI) m/z: ([M+H]+) 222.05; Anal. Calc percent for C9H8N5Cl: C, 48.76; H, 3.61; N, 31.60; Found: C, 48.50; H, 3.32; N, 31.4.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1455-77-2, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Pokharia, Mamta; Yadav, Swatantra K.; Mishra, Hirdyesh; Pandey, Nidhi; Tilak, Ragini; Pokharia, Sandeep; Journal of Molecular Structure; vol. 1144; (2017); p. 324 – 337;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics