Category: 1455-77-2

Synthetic Route of 1455-77-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1455-77-2, name is 3,5-Diamino-1,2,4-triazole, This compound has unique chemical properties. The synthetic route is as follows.

It has been reported that the salts of 1,2,4-triazole and 3-amino-1,2,4-triazole could be obtained via an acid-base neutralization [29, 30]. Likewise, the LiDAtz with two amino groups on the triazole ring was prepared by the neutralization from equimolar 3,5-diamino-1H-1,2,4-triazole (DAtzH) and LiOH. Briefly, equimolar DAtzH and LiOH were added into deionized water separately, mixed and kept reacting and stirring at room temperature for 24 h, and the synthetic process is listed in Scheme 1. The product, a yellow powder, was obtained with 96.8% yield after evaporation of water and then drying at 120 C under vacuum for 24 h. 13C Nuclear magnetic resonance (NMR, 400 MHz, D2O): 161.73 ppm. Fourier transform infrared (FT-IR, KBr, cm-1) spectra: 3374, 3417 (w, nuNH2), 3335 (m, nuH2O), 1608 (m, deltaNH2), 1558 (m, nuC-N), 1475 (s, nuC-N), 1382 (m, nuC-N-C), 1070 (m, nuC-N), 688, 773 (w, deltaN-C-N). Elemental analyses (EA; C2H4N5Li, 105.06): found: C 13.22, H 2.20, N 78.42%; calculated: C 13.20, H 2.22, N 76.96%. High-resolution mass spectra [HRMS-electrospray ionization (ESI)]: m/z: [M+H+] calcd. for C2H5LiN5: 106.0700, found: 106.0700.

The chemical industry reduces the impact on the environment during synthesis 3,5-Diamino-1,2,4-triazole. I believe this compound will play a more active role in future production and life.

Reference:
Article; Fei, Yuqing; Liu, Shimin; Lu, Liujin; He, Yude; Deng, Youquan; Research on Chemical Intermediates; vol. 44; 12; (2018); p. 7187 – 7204;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthetic Route of 1455-77-2, A common heterocyclic compound, 1455-77-2, name is 3,5-Diamino-1,2,4-triazole, molecular formula is C2H5N5, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A suspension of 3,5-diamino-1,2,4-triazole (0.1 g, 1 mmol) in absolute EtOH (10 mL) was added to a stirring solution of azo-coupled precursors, Ia-IVa, (2 mmol) in absolute EtOH (50 mL) during a period of 10 min at 60-70 ¡ãC. The mixture was heated in water bath for 15 h at 80 ¡ãC with stirring. The mixture was filtered whilst hot and the obtained solid was washed with hot ethanol (three time) and then with diethylether. The resulted product was dried in air.

The synthetic route of 1455-77-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Khanmohammadi, Hamid; Erfantalab, Malihe; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 86; (2012); p. 39 – 43;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Reference of 1455-77-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1455-77-2, name is 3,5-Diamino-1,2,4-triazole, This compound has unique chemical properties. The synthetic route is as follows.

A mixture containing Co(NO3)2¡¤6H2O (58.2mg, 0.2mmol), Hdatrz (19.8mg, 0.2mmol) and NH2-H2ip (36.2mg, 0.2mmol) was dissolved in mixed H2O?CH3OH (v:v=1:1, 10.0mL) solution, and the initial pH value of the reactant mixture was adjusted to 6 by triethylamine. The resulting mixture was then transferred into a Teflon-lined stainless steel vessel (23.0mL) and heated at 165¡ãC for 96h under autogenous pressure. After the mixture was cooled to room temperature at a rate of 2.9¡ãCh?1, red block-shaped crystals suitable for X-ray analysis were obtained directly, washed with water and dried in air (Yield: 50percent, based on NH2-H2ip). Anal. Calc. for C36H32Co4N14O17: C, 37.01; H, 2.76; N, 16.78. Found: C, 37.04; H, 2.65; N, 16.72percent. IR (KBr pellet, cm?1): 3409 (br), 3319 (w), 3167 (w), 1625 (s), 1588 (s), 1559 (s), 1481 (s), 1449 (s), 1386 (s), 1322 (w), 1011 (m), 985 (m), 952 (w), 797 (w), 778 (w), 724 (w), 666 (w).

The chemical industry reduces the impact on the environment during synthesis 3,5-Diamino-1,2,4-triazole. I believe this compound will play a more active role in future production and life.

Reference:
Article; Zhao, Hong; Li, Hong-Xue; Liu, Zhong-Yi; Yang, En-Cui; Zhao, Xiao-Jun; Polyhedron; vol. 101; (2015); p. 29 – 36;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

These common heterocyclic compound, 1455-77-2, name is 3,5-Diamino-1,2,4-triazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 3,5-Diamino-1,2,4-triazole

Example 12-Amino-6- [(3-chlorophenyl)methyl] -5-cyclopropyl-4H- [ 1 ,2,4] triazolo [5,1- b] pyrimidin-7-one3,5-Diamino-l,2,4-triazole (141 mg, 1.42 mmol) was added to ethyl 2-[(3- chlorophenyl)methyl]-3-cyclopropyl-3-oxo-propanoate (200 mg, 0.71 mmol) and 1-butyl- 3-methylimidazolium hexafluorophosphate (1 mL, 4.25 mmol) in a microwave tube at room temperature. The open tube was then placed in a fitted aluminium block preheated to 200 ¡ãC and magnetically stirred for 20 minutes with the formation of a white precipitate. After cooling the mixture was added to DCM (30 mL), water (10 mL) and citric acid (10percent aqueous solution, 1 mL) and stirred for 20 minutes. The layers were separated using a hydrophobic membrane filter and the organic layer was evaporated. The remaining aqueous layer was filtered and the solid collected. The crude product was dissolved and purified by preparative HPLC (Waters XTerra CI 8 column, 5mu silica, 19 mm diameter, 100 mm length), using decreasingly polar mixtures of water (containing 0.1percent NH3) and MeCN as eluents. Fractions containing the desired compound were evaporated to dryness to afford the title compound (110 mg, 48.9 percent) as a white solid.1H NMR (700.03 MHz, DMSO-d6) delta 0.85-0.90 (2H, m), 0.93-0.98 (2H, m), 2.06-2.10 (1H, m), 3.98 (2H, s), 6.16 (2H, br s), 7.15-7.21 (2H, m), 7.27-7.29 (2H, m), 12.17 (1H, br s) m/z (ES) (M+H)+ = 316.

The synthetic route of 3,5-Diamino-1,2,4-triazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BENGTSSON, Boel, Ase; BLACKABY, Wesley; CUMMING, John; FAULL, Alan, Wellington; LARSSON, Joakim; NASH, Ian, Alun; OLDHAM, Keith; PAPE, Andrew; WO2011/114148; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

These common heterocyclic compound, 1455-77-2, name is 3,5-Diamino-1,2,4-triazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: Triazoles

4′-nitroacetophenone was used in place of 2-acetylthiophene in Reference Example 001 and heated to reflux in xylene in the presence of N,N-dimethylformamide diethyl acetal as in Reference Example 001, and 3-dimethylamino-1-(4-nitrophenyl)propenone (quantitative) was obtained, which was subsequently reacted with 3,5-diamino-1,2,4-triazole in xylene in the presence of 10-camphor sulfonic acid and the title compound was obtained (yield 82percent).

The synthetic route of 3,5-Diamino-1,2,4-triazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NIPPON KAYAKU KABUSHIKI KAISHA; EP1674454; (2006); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 1455-77-2, name is 3,5-Diamino-1,2,4-triazole, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1455-77-2, COA of Formula: C2H5N5

A mixture of Hdatrz (19.8mg, 0.2mmol), CH3-H2ip (36.0mg, 0.2mmol) and Co(OAc)2¡¤4H2O (24.9mg, 0.1mmol) was dissolved in mixed H2O?CH3OH (v:v=1:1, 10.0mL) solution, and the initial pH value of the reactant mixture was adjusted to ca. 6 by slow addition of triethylamine with constant stirring. The resulting mixture was then transferred into a Teflon-lined stainless steel vessel (23.0mL) and heated at 160¡ãC for 96h under autogenous pressure. After the mixture was cooled to room temperature at a rate of 1.4¡ãCh?1, red block-shaped crystals suitable for X-ray analysis were obtained directly, washed with water and dried in air (Yield: 50percent, based on CoII salt). Anal. Calc. for C12H15CoN5O5: C, 39.14; H, 4.11; N, 19.02. Found: C, 39.14; H, 4.12; N, 19.05percent. IR (KBr pellet, cm?1): 3445 (s), 3333 (w), 3070 (w), 1670 (s), 1633 (s), 1546 (s), 1439 (s), 1370 (s), 1246 (w), 1083 (m), 1032 (m), 817 (w), 783 (m), 751 (w), 723 (m).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Diamino-1,2,4-triazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zhao, Hong; Li, Hong-Xue; Liu, Zhong-Yi; Yang, En-Cui; Zhao, Xiao-Jun; Polyhedron; vol. 101; (2015); p. 29 – 36;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

1455-77-2, name is 3,5-Diamino-1,2,4-triazole, belongs to Triazoles compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: Triazoles

A mixture of Zn(NO3)2?6H2O (0.029 g, 0.10 mmol), Hnic(0.036 g,0.10 mmol), Hdatrz (0.01 g, 0.1 mmol), H2O (2 mL), andDMF (2 mL) was placed in a small vial. The resulting mixture was stirred for 30 min at room temperature, and thenthe mixture was kept at 110C for three days. After beingslowly cooled to the room temperature, colorless block crystals of 1were isolated in 35percent yield based on Zn(II). Anal. Calcd. for C16H16N12O4Zn2(571.19): C, 33.61; N, 29.41; H,2.80percent. Found: C, 33.62; N, 29.38; H, 2.84percent.

The synthetic route of 1455-77-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Bu, Xianzhong; Chen, Jinquan; Hu, Mingzhen; Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry; vol. 46; 1; (2016); p. 123 – 126;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1455-77-2 as follows. HPLC of Formula: C2H5N5

A mixture of Zn(NO3)26H2O (0.030 g, 0.1 mmol), H3bpt (0.025 g,0.1 mmol), Hdatrz (0.01 g, 0.1 mmol), DMF (3 mL) and CH3OH(1 mL) was placed in a small vial at 90 C for 72 h and then cooledto room temperature slowly. Colorless block crystals were obtainedin 42percent yield based on Zn(NO3)26H2O. Anal. calcd. forC36H29N11O12Zn3 (1004.88): C, 42.99; H, 2.89; N, 15.33percent. Found: C,42.89; H, 2.85; N, 15.42percent. IR (cm1): 3422(w), 1712(m), 1675(s),1587(m), 1509(m), 1389(m), 1378(m), 1109(w), 1025(w), 958(m),893(m), 826(m), 778(w), 690(w), 674(w), 589(w), 562(w).

According to the analysis of related databases, 1455-77-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Zhao, Haixiang; Dong, Yanli; Liu, Haiping; Journal of Molecular Structure; vol. 1105; (2016); p. 112 – 117;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 1455-77-2, name is 3,5-Diamino-1,2,4-triazole, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1455-77-2, Safety of 3,5-Diamino-1,2,4-triazole

3,5-Diamino-1,2,4-triazole was dissolved in 66percent hydrofluoric acid aqueous solution. After short heating in a water bath and slow cooling, crystals of (HL)(H2L)(HF2)2F compound (I) were found.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Diamino-1,2,4-triazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Goreshnik, Evgeny; Journal of Fluorine Chemistry; vol. 197; (2017); p. 94 – 99;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

1455-77-2, name is 3,5-Diamino-1,2,4-triazole, belongs to Triazoles compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 3,5-Diamino-1,2,4-triazole

Potassium tetranitropropane (200 mg, 0.67 mmol) was added to 20 mL of a mixed solvent of methanol and water (1:1 by volume), then concentrated hydrochloric acid (0.14 mL, 37%, 1.67 mmol) was added dropwise.Then, 3,5-diamino-1,2,4-triazole (293 mg, 1.34 mmol) was added and reacted at room temperature for 2 h. The reaction of the starting material was completely monitored by TLC, and a certain amount of NaHCO3 was added.Then add anhydrous magnesium sulfate to dry, spin dry, and pass the column (PE: EA = 4:1).A yellow solid 168 mg was obtained in 40% yield.

The synthetic route of 1455-77-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Organic Chemistry Institute; Yang Jun; Huang Haifeng; Shi Yameng; (17 pag.)CN110128344; (2019); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics