Category: 151899-62-6

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 151899-62-6, name is 3-Iodo-1-trityl-1H-1,2,4-triazole, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 3-Iodo-1-trityl-1H-1,2,4-triazole

Step 2: Preparation of 5-(3-chloro-4-fluorophenyl)-3-methyl-3-(pyrimidin-5-ylmethyl)-l-(l- trityl-l,2,4-triazol-3yl)-l,3-dihydro-2H-indol-2-oneTo 5-(3-chloro-4-fluorophenyl)-3-methyl- 1 -pyrimidin-2-yl- 1 ,3-dihydro-2H-indol-2-one (648 mg, 1.76 mmol), l-trityl-3-iodo-l,2,4-triazole (809 mg, 1.85 mmol, prepared using similar procedures as described in US Pat. No. 5,393,732 incorporated herein by reference in its entirety. Potassium carbonate (1071 mg, 7.75 mmol), N, N’-dimethylethylenediamine (0.300 mL, 2.82 mmol) and copper (I) iodide (268 mg, 1.41 mmol) under nitrogen was added toluene (15 mL).The mixture was stirred at 100 0C for 18 hours. The mixture was cooled and the solvent was evaporated under reduced pressure. The residue was purified by column chromatography on silica gel Biotage 25S, eluting with 0-100% ethyl acetate/hexanes, to afford -(3-chloro-4- fluorophenyl)-3-methyl-l-pyrimidin-2-yl-l,3-dihydro-2H-indol-2-one as a white solid. 1H NMR (CDCl3): delta 8.98 (s, 1 H), 8.34 (s, 2 H), 8.04 (s, 1 H), 7.56 (m, 1 H), 7.41 (m, 1 H), 7.30(m, 18 H), 7.05 (d, 1 H, J = 8.3 Hz), 3.31 (d, I H1 J = 13.7 Hz), 3.12 (d, I H1 J = 13.8 Hz) 1.59 (s,3H)MS: m/e 699.24 (M + Na)+

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 151899-62-6.

Reference:
Patent; MERCK & CO., INC.; WO2009/45386; (2009); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Related Products of 151899-62-6, A common heterocyclic compound, 151899-62-6, name is 3-Iodo-1-trityl-1H-1,2,4-triazole, molecular formula is C21H16IN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Nitrogen gas was bubbled through a solution of (15)-3-[(25r,3lambda)-2-(4-{4- (acetyloxy)-3 – [(acetyloxy)methyl] -3 -hydroxybut- 1 -yn- 1 -yl } phenyl)- 1 -(4-ethynylphenyl)-4- oxoazetidin-3-yl]-l-(4-fluorophenyl)propyl acetate (4.Og, 6.3mmol; intermediate step B), 3-iodo- l-trityl-lH-l,2,4-triazole (i-8) (5.47g, 12.5mmol), triethylamine (4.4mL, 31.3mmol), and tetra-n- butylammonium iodide (2.3 Ig, 6.3mmol) in anhydrous DMF (5mL) and was heated at 5O0C for 20 minutes. Pd(PPh3)4 (0.72g, 0.63mmol) and CuI (0.2g, 1.25mmol) were added and the reaction mixture was heated at 5O0C under nitrogen atmosphere for ~18hr. The reaction mixture was cooled to RT, poured into water (70OmL) and extracted with EtOAc (3x200mL). The combined organic layers were washed with water (2x500mL), brine (20OmL) dried over Na2SO4,10 filtered and the solvent removed under vacuum. The residue was purified by column chromatography eluting with 0%EtOAc/hexanes then gradient from 0%EtOAc/hexanes to 50%EtOAc/hexanes then 50% EtOAc/hexanes to 60% EtOAc/hexanes then 60% EtOAc/hexanes to afford the title compound. 1HNMR (500 MHz, CDCl3) delta: 8.03 (s, IH), 7.45 (d, J = 8.0, 2H), 7.44 (d, J = 8.7, 2H), 7.36 (m, 9H), 7.29 (m, 4H), 7.19 (d, J – 8.7, 2H), 7.15 (m, 6H), 7.04 (t, J =15 8.4, 2H), 5.71 (t, J – 6.6, IH), 4.63 (d, J = 2.3, IH), 4.39 (d, J = 11.5, 2H), 4.32 (d, J = 11.5, 2H), 3.36 (s, IH), 3.08 (m, IH), 2.15 (s, 6H), 2.07 (s, 3H), 2.07-2.02 (m, 2H), 1.93-1.85 (m, 2H).

The synthetic route of 151899-62-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK & CO., INC.; WO2008/57336; (2008); A2;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Electric Literature of 151899-62-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 151899-62-6, name is 3-Iodo-1-trityl-1H-1,2,4-triazole belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below.

3-iodo-1-trityl -1H-1,2,4- triazole (300 mg),3-cyanophenyl boronic acid (101 mg), tetrakis triphenylphosphine palladium (79 mg), ethanol 2M aqueous sodium carbonate (1.5 mL) (1.0 mL) – toluene (1.5 mL) mixed solution of the mixture was stirred for 4 hours at 100 C. After cooling to room temperature, and separated the two layers.The aqueous layer was extracted with ethyl acetate, it was concentrated under reduced pressure and the organic layers were washed with. The residue was purified by column chromatography (silica gel cartridge, hexane: ethyl acetate = 88: 12-50: 50) to give the title compound (227 mg) as a colorless solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Iodo-1-trityl-1H-1,2,4-triazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TAISHO PHARMACEUTICAL COMPANY LIMITED; KONISHI, KAZUHIDE; KANUMA, KOSUKE; NAKAMURA, TOSHIO; AMADA, HIDEAKI; YAMAMOTO, SHUJI; KASHIWA, SHUHEI; MASUDA, SEIJI; OKADA, KUMIKO; KAWAMOTO, HIROSHI; (74 pag.)JP2015/78127; (2015); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

These common heterocyclic compound, 151899-62-6, name is 3-Iodo-1-trityl-1H-1,2,4-triazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C21H16IN3

Nitrogen gas was bubbled through a solution of 3-iodo-1-trityl-1H-1,2,4-triazole (i-28, 37.3 g, 85.35 mmol) and triethylamine (17.8 ml, 128 mmol) in anhydrous DMF (300 ml) heated at 35 C. for 30 mins. Pd(PPh3)2Cl2 (2.4 g, 3.4 mmol) and CuI (651 mg, 3.4 mmol) were added followed by addition of ethynyltrimethylsilane (18 ml, 128 mmol) in anhydrous DMF (18 ml) over 15 hours via syringe pump. After complete addition the mixture was heated at 35 C. for a further 5 hours. The mixture was poured into water (700 ml) and extracted with EtOAc (3¡Á300 ml). Combined EtOAc layers were washed with water (2¡Á500 ml), sat. NaCl (250 ml), dried over Na2SO4, filtered and evaporated. The residue was purified by MPLC on silica gel eluting with a gradient from 100% hexanes to 10% EtOAc in hexanes to afford the title compound. 1HNMR (500 MHz, CDCl3) delta: 7.96 (s, 1H), 7.37 (m, 9H), 7.14 (m, 6H), 0.27 (s, 9H)

The synthetic route of 3-Iodo-1-trityl-1H-1,2,4-triazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Morriello, Gregori J.; DeVita, Robert J.; US2008/280836; (2008); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics