Category: 16227-12-6

Research speed reading in 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 16227-12-6, name is 4-Phenyl-4H-1,2,4-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 4-Phenyl-4H-1,2,4-triazole

General procedure: 1,4-bis(Bromomethyl)benzene (0.20 g, 0.76 mmol) and the appropriateimidazole or triazole (1.60 mmol) in DCM (3 mL) were refluxed for 12.16 h in a 10 mL Ace pressure tube. The reaction mixture was cooledto room temperature and extracted with water (3 ~ 5 mL). The aqueousphase was dried in vacuo and the crude product crystallised frommethanol/acetone (1:4) to give pure product as a white solid.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 16227-12-6, and we look forward to future research findings.

Reference:
Article; Du, Yufeng; Tang, Huiling; Ding, Hong; Shi, Yanhui; Cao, Changsheng; Pang, Guangsheng; Journal of Chemical Research; vol. 40; 12; (2016); p. 735 – 739;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

New discoveries in chemical research and development in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 16227-12-6, name is 4-Phenyl-4H-1,2,4-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 4-Phenyl-4H-1,2,4-triazole

EXAMPLE 127 4-phenyl-1-(pent-1-yl)triazolium bromide 0.15 g (0.001 mol) 4-phenyltriazole 1 and 0.37 ml (0.45 g, 0.003 mol) 1-bromopentane 2 are combined in a pressure tube. The mixture is stirred 12 h at 110 C. Subsequently, it is cooled down to room temperature. The precipitated solid is taken up in a 1:1 mixture of THF and petroleum ether, is filtered off, and washed with diethylether. M 296.21 C13H18N3Br Yield: 0.231 g (78%) 1H-NMR DM-229 (300 MHz/DMSO): (ppm)=0.88 (t, 3H, 11-H); 1.37 (m, 4H, 9); 1.96 (q, 2H, 8-H); 4.44 (t, 2H, 7-H); 7.69 (m, 3H, 5/5’/6H); 7.85 (d, 2H, 4/4′-H); 9.81 (s, 1H, 2-H); 10.86 (s, 1H, 1-H) 13C-NMR DM-229 (75.475 MHz/DMSO):

If you are hungry for even more, make sure to check my other article about 16227-12-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TECHNISCHE UNIVERSITAET DRESDEN; US2011/105761; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application of 16227-12-6, New Advances in Chemical Research in 2021.In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 16227-12-6, name is 4-Phenyl-4H-1,2,4-triazole, molecular formula is C8H7N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

EXAMPLE 128 4-phenyl-1-(hept-1-yl)triazolium bromide 0.15 g (0.001 mol) 4-phenyltriazole 1 and 0.47 ml (0535 g, 0.003 mol) 1-bromoheptane 2 are combined in a pressure tube. The mixture is stirred for 12 h at 110 C. Subsequently, it is cooled down to room temperature. The precipitated solid is taken up in a 1:1 mixture of THF and petroleum ether, is filtered off, and washed with diethylether. M 324.26 C15H22N3Br Yield: 0.306 (94%) 1H-NMR DM-230 (300 MHz/DMSO): (ppm)=0.88 (t, 3H, 13-H); 1.37 (m, 8H, 9/10/11/12H); 1.96 (q, 2H, 8-H); 4.44 (t, 2H, 7-H); 7.69 (m, 3H, 5/5’/6H); 7.85 (d, 2H, 4/4′-H); 9.81 (s, 1H, 2-H); 10.85 (s, 1H, 1-H) 13C-NMR DM-230 (75.475 MHz/DMSO):

Future efforts will undeniably focus on the diversification of the new catalytic transformations. These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. Keep reading other articles of 16227-12-6.

Reference:
Patent; TECHNISCHE UNIVERSITAET DRESDEN; US2011/105761; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Research speed reading in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 16227-12-6, name is 4-Phenyl-4H-1,2,4-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. category: Triazoles

EXAMPLE 125 4-phenyl-1-(ethyl)triazolium bromide 0.15 g (0.001 mol) 4-phenyltriazole 1 and 0.22 ml (0.32 g, 0.003 mol) 1-bromoethane 2 are combined in a pressure tube. The mixture is stirred 12 h at 110 C. Subsequently, it is cooled down to room temperature. The precipitated solid is taken up in a 1:1 mixture of THF and petroleum ether, is filtered off, and washed with diethylether. M 254.13 C10H12N3Br Yield: 0.2307 g (97%) 1H-NMR DM-226 (300 MHz/DMSO): (ppm)=1.57 (t, 3H, 8-H); 4.49 (q, 2H, 7-H); 7.71 (m, 3H, 5/5’/6H); 7.87 (d, 2H, 4/4′-H); 9.82, (s, 1H, 2-H); 10.88 (s, 1H, 1-H) 13C-NMR DM-226 (75.475 MHz/DMSO):

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 4-Phenyl-4H-1,2,4-triazole, in my other articles.

Reference:
Patent; TECHNISCHE UNIVERSITAET DRESDEN; US2011/105761; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

New discoveries in chemical research and development in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world.16227-12-6, name is 4-Phenyl-4H-1,2,4-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 16227-12-6

EXAMPLE 130 4-phenyl-1-(undec-1-yl)triazolium bromide 0.15 g (0.001 mol) 4-phenyltriazole 1 and 0.486 g (0.003 mol) 1-bromoheptane 2 are combined in a pressure tube. The mixture is stirred for 12 h at 110 C. Subsequently, it is cooled down on room temperature. The precipitated solid is taken up in a 1:1 mixture of THF and petroleum ether, is filtered off, and washed with diethylether. M 380.37 C15H22N3Br Yield: 0.242 g (64%) 1H-NMR DM-230 (300 MHz/DMSO): (ppm)=0.88 (t, 3H, 13-H); 1.37 (m, 8H, 9/10/11/12H); 1.96 (q, 2H, 8-H); 4.44 (t, 2H, 7-H); 7.69 (m, 3H, 5/5’/6H); 7.85 (d, 2H, 4/4′-H); 9.81 (s, 1H, 2-H); 10.85 (s, 1H, 1-H) 13C-NMR DM-230 (75.475 MHz/DMSO):

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 4-Phenyl-4H-1,2,4-triazole ,and how the biochemistry of the body works.

Reference:
Patent; TECHNISCHE UNIVERSITAET DRESDEN; US2011/105761; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Related Products of 16227-12-6, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 16227-12-6, name is 4-Phenyl-4H-1,2,4-triazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 129 4-phenyl-1-(hex-1-yl)triazolium bromide 0.15 g (0.001 mol) 4-phenyltriazole 1 and 0.42 ml (0.495 g, 0.003 mol) 1-bromohexane 2 are combined in a pressure tube. The mixture is stirred for 12 h at 110 C. Subsequently, it is cooled down to room temperature. The precipitated solid is taken up in a 1:1 mixture of THF and petroleum ether, is filtered off, and washed with diethylether. M 310.23 C14H20N3Br Yield: 0.254 g (82%) 1H-NMR DM-231 (300 MHz/DMSO): (ppm)=0.89 (t, 3H, 12-H); 1.33 (m, 6H, 9/10/11H): 1.96 (q, 2H, 8-H); 4.45 (t, 2H, 7-H); 7.69 (m, 3H, 5/5’/6H); 7.86 (d, 2H, 4/4′-H); 9.81 (s, 1H, 2-H); 10.88 (s, 1H, 1-H) 13C-NMR DM-231 (75.475 MHz/DMSO):

Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.In my other articles, you can also check out more blogs about 4-Phenyl-4H-1,2,4-triazole.

Reference:
Patent; TECHNISCHE UNIVERSITAET DRESDEN; US2011/105761; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Reference of 16227-12-6, New Advances in Chemical Research in 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 16227-12-6, name is 4-Phenyl-4H-1,2,4-triazole, molecular formula is C8H7N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

EXAMPLE 131 4-phenyl-1-(tetradec-1-yl)-(1,2,4)-triazolium bromide 0.100 g (0.0007 mol) 4-phenyl-(1,2,4)-triazole 1 and 0.572 g (0.0021 mol) 1-bromotetradecane 2 are combined in a pressure tube. The reaction mixture is stirred 3 d at 110 C. To the resulted solid 10 ml petroleum ether was added. The product is filtered off, washed with petroleum ether/THF 1:1 and diethylether, and is dried in high vacuum. M 422.53 C22H36N3Br Yield: 0.242 g (74%) 1H-NMR DM-233 (300 MHz/DMSO): (ppm)=0.85 (t, 3H, 20-H); 1.24 (m, 24H, 9-19-H); 1.94 (q, 2H, 8-H); 4.42 (t, 21-1,7-H); 7.71 (m, 3H, 5/5’/6H); 7.82 (d, 2H, 4/4′-H); 9.78 (s, 1H, 1-H); 10.79 (s, 1H, 2-H) 13C-NMR DM-233 (75.475 MHz/DMSO):

In the meantime we’ve collected together some recent articles in this area about 4-Phenyl-4H-1,2,4-triazole to whet your appetite. Happy reading!

Reference:
Patent; TECHNISCHE UNIVERSITAET DRESDEN; US2011/105761; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16227-12-6, name is 4-Phenyl-4H-1,2,4-triazole, This compound has unique chemical properties. The synthetic route is as follows., category: Triazoles

EXAMPLE 127 4-phenyl-1-(pent-1-yl)triazolium bromide 0.15 g (0.001 mol) 4-phenyltriazole 1 and 0.37 ml (0.45 g, 0.003 mol) 1-bromopentane 2 are combined in a pressure tube. The mixture is stirred 12 h at 110 C. Subsequently, it is cooled down to room temperature. The precipitated solid is taken up in a 1:1 mixture of THF and petroleum ether, is filtered off, and washed with diethylether. M 296.21 C13H18N3Br Yield: 0.231 g (78%) 1H-NMR DM-229 (300 MHz/DMSO): (ppm)=0.88 (t, 3H, 11-H); 1.37 (m, 4H, 9); 1.96 (q, 2H, 8-H); 4.44 (t, 2H, 7-H); 7.69 (m, 3H, 5/5’/6H); 7.85 (d, 2H, 4/4′-H); 9.81 (s, 1H, 2-H); 10.86 (s, 1H, 1-H) 13C-NMR DM-229 (75.475 MHz/DMSO):

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 16227-12-6.

Reference:
Patent; TECHNISCHE UNIVERSITAET DRESDEN; US2011/105761; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Electric Literature of 16227-12-6, These common heterocyclic compound, 16227-12-6, name is 4-Phenyl-4H-1,2,4-triazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 131 4-phenyl-1-(tetradec-1-yl)-(1,2,4)-triazolium bromide 0.100 g (0.0007 mol) 4-phenyl-(1,2,4)-triazole 1 and 0.572 g (0.0021 mol) 1-bromotetradecane 2 are combined in a pressure tube. The reaction mixture is stirred 3 d at 110 C. To the resulted solid 10 ml petroleum ether was added. The product is filtered off, washed with petroleum ether/THF 1:1 and diethylether, and is dried in high vacuum. M 422.53 C22H36N3Br Yield: 0.242 g (74%) 1H-NMR DM-233 (300 MHz/DMSO): (ppm)=0.85 (t, 3H, 20-H); 1.24 (m, 24H, 9-19-H); 1.94 (q, 2H, 8-H); 4.42 (t, 21-1,7-H); 7.71 (m, 3H, 5/5’/6H); 7.82 (d, 2H, 4/4′-H); 9.78 (s, 1H, 1-H); 10.79 (s, 1H, 2-H) 13C-NMR DM-233 (75.475 MHz/DMSO):

The synthetic route of 16227-12-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TECHNISCHE UNIVERSITAET DRESDEN; US2011/105761; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16227-12-6, name is 4-Phenyl-4H-1,2,4-triazole, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 16227-12-6

EXAMPLE 125 4-phenyl-1-(ethyl)triazolium bromide 0.15 g (0.001 mol) 4-phenyltriazole 1 and 0.22 ml (0.32 g, 0.003 mol) 1-bromoethane 2 are combined in a pressure tube. The mixture is stirred 12 h at 110 C. Subsequently, it is cooled down to room temperature. The precipitated solid is taken up in a 1:1 mixture of THF and petroleum ether, is filtered off, and washed with diethylether. M 254.13 C10H12N3Br Yield: 0.2307 g (97%) 1H-NMR DM-226 (300 MHz/DMSO): (ppm)=1.57 (t, 3H, 8-H); 4.49 (q, 2H, 7-H); 7.71 (m, 3H, 5/5’/6H); 7.87 (d, 2H, 4/4′-H); 9.82, (s, 1H, 2-H); 10.88 (s, 1H, 1-H) 13C-NMR DM-226 (75.475 MHz/DMSO):

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 16227-12-6.

Reference:
Patent; TECHNISCHE UNIVERSITAET DRESDEN; US2011/105761; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics