Category: 20725-34-2

Research speed reading in 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 20725-34-2, name is 1-(4-Bromophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C10H8BrN3O2

In a 20 mL reaction vial, l-(4-bromo-phenyl)-5-methyl-lH-[l ,2,3]triazole-4-carboxylic acid (0.67 g, 2.38 mmol), (R)-l-phenylethanol (0.29 g, 0.29 mL, 2.4 mmol) and triethylamine (0.24 g, 0.33 mL, 2.4 mmol) were combined with toluene (100 mL) to give a yellow solution and to this was added diphenylphosphorylazide (0.65 g, 0.5 mL, 2.4 mmol). The vial’s atmosphere was purged with nitrogren, sealed, heated in a dry block at 80 C for 4 h, and cooled to room temperature overnight. The reaction was diluted with EtOAc (100 mL) and washed with water (100 mL) and brine (50 mL). The aqueous layers were extracted with EtOAc (100 mL). The organic layers were combined, dried over MgS04, filtered, concentrated, dissolved in minimal DCM, and purified by flash chromatography (silica gel, 0% to 25% EtOAc in hexanes). Appropriate fractions combined, concentrated, dried from DCM / hexanes, to give [l-(4-bromo-phenyl)-5-methyl-lH-[l ,2,3]triazol-4-yl]-carbamic acid (R)-l-phenyl-ethyl ester (0.507 g, 53.2% yield) as an off-white solid. LC/MS calcd. for Ci8Hi7BrN402 (m/e) 400/402, obsd. 401/403 (M+H, ES+).

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 20725-34-2, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GABRIEL, Stephen Deems; HAMILTON, Matthew Michael; QIAN, Yimin; SIDDURI, Achyutharao; WO2013/189865; (2013); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 20725-34-2, name is 1-(4-Bromophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20725-34-2, Product Details of 20725-34-2

In a 20 mL reaction vial, l-(4-bromo-phenyl)-5-methyl-lH-[l ,2,3]triazole-4-carboxylic acid (0.67 g, 2.38 mmol), (R)-l-phenylethanol (0.29 g, 0.29 mL, 2.4 mmol) and triethylamine (0.24 g, 0.33 mL, 2.4 mmol) were combined with toluene (100 mL) to give a yellow solution and to this was added diphenylphosphorylazide (0.65 g, 0.5 mL, 2.4 mmol). The vial’s atmosphere was purged with nitrogren, sealed, heated in a dry block at 80 C for 4 h, and cooled to room temperature overnight. The reaction was diluted with EtOAc (100 mL) and washed with water (100 mL) and brine (50 mL). The aqueous layers were extracted with EtOAc (100 mL). The organic layers were combined, dried over MgS04, filtered, concentrated, dissolved in minimal DCM, and purified by flash chromatography (silica gel, 0% to 25% EtOAc in hexanes). Appropriate fractions combined, concentrated, dried from DCM / hexanes, to give [l-(4-bromo-phenyl)-5-methyl-lH-[l ,2,3]triazol-4-yl]-carbamic acid (R)-l-phenyl-ethyl ester (0.507 g, 53.2% yield) as an off-white solid. LC/MS calcd. for Ci8Hi7BrN402 (m/e) 400/402, obsd. 401/403 (M+H, ES+).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(4-Bromophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GABRIEL, Stephen Deems; HAMILTON, Matthew Michael; QIAN, Yimin; SIDDURI, Achyutharao; WO2013/189865; (2013); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthetic Route of 20725-34-2,Some common heterocyclic compound, 20725-34-2, name is 1-(4-Bromophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid, molecular formula is C10H8BrN3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of compound 7 (5 mmol) in POCl3(15 mL), a solution of compound 11 (5 mmol) in ethanol (25 mL) was added and the reaction mixture was heated under reflux for 14 h under anhydrous conditions. The solvent was distilled in vacuo, the residual mass was poured over crushed ice and the excess POCl3 was neutralized with 10% sodium bicarbonate solution. The solid thus separated was filtered, washed with 10% sodium bicarbonate solution and finally with water, dried and purified by recrystallization from ethanol to give pure compounds12a-j.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(4-Bromophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid, its application will become more common.

Reference:
Article; Sanjeeva Reddy; Vani Devi; Sunitha; Kalyani; Nagaraj; Indian Journal of Chemistry – Section B Organic and Medicinal Chemistry; vol. 55B; 5; (2016); p. 590 – 597;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics