Category: 217448-86-7

Reference of 217448-86-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 217448-86-7, name is Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below.

Example 4 Preparation of Rufinamide (I). Mixture of 10 g (0.039 mol) of methyl-1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate, and 150 ml of methanolic ammonia solution was stirred at ambient temperature. The reaction mixture was heated to 45 C. for 22 hours. Cooled to ambient temperature. Solid was filtered, washed with methanol and dried under reduced pressure. Yield 69 g (87%); HPLC purity: 99.83%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; LUPIN LIMITED; Siyan, Rajinder Singh; Aher, Yogesh Subhas; Bhise, Nandu Baban; Singh, Girij Pal; Gohel, Sunilkumar Vinubhai; US2014/357871; (2014); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Related Products of 217448-86-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 217448-86-7, name is Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

Example 8; Synthesis of compound (I): 1-(2,6-Difluorobenzyl)-1H-1,2,3-triazole-4-carboxyamide (Rufinamide) Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate (II) (10.6 g, 41.9 mmoles), prepared as reported in Example 7, is dissolved in methanol (10 ml) and treated at room temperature under stirring with a 30% ammonia aqueous solution (40 ml), then the reaction mixture is refluxed and kept under stirring for 3 hours. The mixture is cooled to 20C, then diluted with water, filtered, and the resulting white solid is washed with water and dried in a static dryer at 50C. Rufinamide (8.7 g) is obtained as a crystalline white solid in 87% yield. 1H NMR (400 MHz, DMSO-d6), delta ppm: 8.56 (s, 1 H), 7.87 (bs, 1H), 7.60-7.43 (m, 2H), 7.20 (m, 2H), 5.72 (s, 2H).

The chemical industry reduces the impact on the environment during synthesis Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Dipharma Francis S.r.l.; EP2230234; (2010); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Electric Literature of 217448-86-7, These common heterocyclic compound, 217448-86-7, name is Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 8Synthesis of Compound (I)1-(2,6-Difluorobenzyl)-1H-1,2,3-triazole-4-carboxyamide (Rufinamide); Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate (II) (10.6 g, 41.9 mmoles), prepared as reported in Example 7, is dissolved in methanol (10 ml) and treated at room temperature under stirring with a 30% ammonia aqueous solution (40 ml), then the reaction mixture is refluxed and kept under stirring for 3 hours. The mixture is cooled to 20 C., then diluted with water, filtered, and the resulting white solid is washed with water and dried in a static dryer at 50 C. Rufinamide (8.7 g) is obtained as a crystalline white solid in 87% yield.1H NMR (400 MHz, DMSO-d6), delta ppm: 8.56 (s, 1H), 7.87 (bs, 1H), 7.60-7.43 (m, 2H), 7.20 (m, 2H), 5.72 (s, 2H).

Statistics shows that Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate is playing an increasingly important role. we look forward to future research findings about 217448-86-7.

Reference:
Patent; DIPHARMA FRANCIS S.R.L.; US2010/234616; (2010); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

A common heterocyclic compound, 217448-86-7, name is Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate, molecular formula is C11H9F2N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 217448-86-7.

ExampIe-4: Preparation of l-(2, 6-difIuorobenzyl)-lH-l, 2, 3-triazole-4- carboxylic acid[0029] A mixture of Methyl l -(2, 6-difluorobenzyl)-l H- l, 2, 3-triazole-4- carboxylate. (50 gms) and a solution of sodium hydroxide ( 1 1.76 gms in 100ml water) were stirred at room temperature contents till it becomes clear. Hydrochloric acid (30ml) in DM water (70 ml) was charged to above reaction mass. Adjusted the PH of the reaction till 2-3 by adding the hydrochloric acid solution at 25-30C. After the completion, reaction mass was filtered and dried the material at 65C-70C for 15 hours. Yield: 40gms Example

The synthetic route of Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DAVULURI, Ramamohan Rao; WO2012/25936; (2012); A2;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

A common heterocyclic compound, 217448-86-7, name is Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate, molecular formula is C11H9F2N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 217448-86-7.

Mixture of 10 g (0.039 mol) of methyl- l-(2,6-difluorobenzyl)-lH-l,2,3-triazole-4- carboxylate, and 150 ml of methanolic ammonia solution was stirred at ambient temperature. The reaction mixture was heated to 45C for 22 hours. Cooled to ambient temperature. Solid was filtered, washed with methanol and dried under reduced pressure. Yield 69 g (87%); HPLC purity: 99.83%.

The synthetic route of Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LUPIN LIMITED; SIYAN, Rajinder, Singh; AHER, Yogesh, Subhas; BHISE, Nandu, Baban; SINGH, Girij, Pal; GOHEL, Sunilkumar Vinubhai; WO2013/105029; (2013); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

A common compound: 217448-86-7, name is Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate, belongs to Triazoles compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 217448-86-7

In a 250 ml round bottom flask, 2,6-difluorobenzylbromide (0.024 mol, 5 g), sodium azide (0.026 mol, 1.72 g) and water (50 ml) were added. The reaction mixture was heated to 700C to 750C for 30 hours and formation of the azide intermediate was monitored by thin layer chromatography (TLC). After the completion of reaction, the reaction contents were cooled to room temperature and then to this methyl propiolate (0.024 mol, 2.1 ml) was added dropwise, maintaining the contents at room temperature. On complete addition, the mixture was again heated at 600C to 650C for 4 to 5 hours. After the reaction was completed, the contents were cooled to room temperature and to this 25% aqueous ammonia (40 ml) solution was added dropwise. The reaction contents were heated to 700C to 750C for 4 to 5 hours and then gradually cooled to room temperature. The solid obtained was filtered and washed with water. The product was dried under vacuum at 700C – 750C to give 3.0 g of rufinamide.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 217448-86-7, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CIPLA LIMITED; KANKAN, Rajendra, Narayanrao; RAO, Dharmaraj, Ramachandra; BIRARI, Dilip, Ramdas; CURTIS, Philip, Anthony; WO2010/43849; (2010); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics