Category: 28938-17-2

New discoveries in chemical research and development in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 28938-17-2, name is 4,5-Dibromo-2-methyl-2H-1,2,3-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. 28938-17-2

4-bromo-2-methyl-2H-l,2,3-triazole. n-Butyllithium (8.3 mL) was added dropwise to a solution of 4,5-dibromo-2-methyl-2H-l,2,3-triazole (2.0 g, 8.37 mmol) in tetrahydrofuran (50 mL) under -78C, Once addition was completed, the mixture was stirred for another 30 minutes at -78C. The reaction was quenched with water, extracted with ethyl acetate (50 mL x 3), washed by brine (30 mL x 3). The organic phase was dried over anhydrous sodium sulfate and then filtered. The filtrate was concentrated in vacuo to afford 4-bromo-2-methyl-2H- 1,2,3- triazole.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 4,5-Dibromo-2-methyl-2H-1,2,3-triazole help many people in the next few years.

Reference:
Patent; CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; GEHLING, Victor, S.; HEWITT, Michael, C.; TAYLOR, Alexander, M.; HARMANGE, Jean-Christophe; WO2012/151512; (2012); A2;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Research speed reading in 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic. 28938-17-2, name is 4,5-Dibromo-2-methyl-2H-1,2,3-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 28938-17-2

Example 21 1.20 g (5.0 mmol) of 2-methyl-4,5-dibromo-2H-1,2,3-triazole was dissolved in 10 ml of tetrahydrofuran, cooled to -20?0C, 2.74 ml (5.18 mmol) of 2.0M isopropylmagnesium tetrahydrofuran solution was added dropwise slowly in 30 minutes. Added dropwise was completed, continued to stir for 30?60 minutes. 1.26 g (5.0 mmol) of solid iodine was added, continued to react for 30 minutes. Reaction liquid was added by 20 ml of saturated ammonium chloride aqueous solution, extracted by using 30 ml of ethyl acetate, dried by anhydrous sodium sulfate, concentrated to dry under reduced pressure, the residual solid was added by 10 ml of isopropanol/water (5/1), heated to reflux for 1 hour, cooled to 0?10C, continued to be stirred for 1 hour, filtered, vacuum dried under a temperature <40C. 1.16 g of 2-methyl-4-bromo-5-iodo-2H-1,2,3-triazole solid was obtained, the yield was 81%. 1H NMR (CDCl3, 400 MHz): delta 4.20 (s, 3H); 13C NMR (CDCl3, 400 MHz): delta 130.4, 94.6, 43.0. In conclusion, we affirm that quantitative kinetic descriptions of catalytic behavior continue to serve as an indispensable tool to navigate research efforts intended to model. Read on for other articles about 28938-17-2. Reference:
Patent; ABA Chemicals Corporation; JIANG, Yueheng; QUE, Limin; CAI, Tong; QIN, Dongguang; EP2889292; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

New discoveries in chemical research and development in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 28938-17-2, name is 4,5-Dibromo-2-methyl-2H-1,2,3-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. 28938-17-2

4-bromo-2-methyl-2H-l,2,3-triazole. n-Butyllithium (8.3 mL) was added dropwise to a solution of 4,5-dibromo-2-methyl-2H-l,2,3-triazole (2.0 g, 8.37 mmol) in tetrahydrofuran (50 mL) under -78C, Once addition was completed, the mixture was stirred for another 30 minutes at -78C. The reaction was quenched with water, extracted with ethyl acetate (50 mL x 3), washed by brine (30 mL x 3). The organic phase was dried over anhydrous sodium sulfate and then filtered. The filtrate was concentrated in vacuo to afford 4-bromo-2-methyl-2H- 1,2,3- triazole.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 4,5-Dibromo-2-methyl-2H-1,2,3-triazole help many people in the next few years.

Reference:
Patent; CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; GEHLING, Victor, S.; HEWITT, Michael, C.; TAYLOR, Alexander, M.; HARMANGE, Jean-Christophe; WO2012/151512; (2012); A2;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

These common heterocyclic compound, 28938-17-2, name is 4,5-Dibromo-2-methyl-2H-1,2,3-triazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C3H3Br2N3

Intermediate 14d (0551) 5-Bromo-2-methyl-2H- 1 ,2,3-triazole-4-carboxylic acid (0552) A solution of 4,5-dibromo-2-methyl-2H-l,2,3-triazole (Intermediate 14e; 144 g, 597.81 mmol) in anhydrous THF (1.5 L) was cooled to -30 C under nitrogen atmosphere and i- PrMgCl (330 mL, 658 mmol, 2M in THF) was added dropwise. The solution was stirred at -30 C for 1 hour, and then bubbled with C02 for 3 hours at <10 C. The reaction was then stirred at 25 C for 16 hours. The mixture was quenched with aqueous HC1 (-3000 mL, 0.1M) to pH = ~2 and extracted with EtOAc (3 L x 3). The organic phase was then extracted with aqueous NaOH (0.1M, 2 L x 3). The aqueous phase was then added to aqueous HC1 (~6 L, 0.1M) to pH=~2 and extracted with EtOAc (3L x 3). The organic phase was dried with Na2S04 and concentrated under vacuum to give 5-bromo-2-methyl- 2H-l,2,3-triazole-4-carboxylic acid (Intermediate 14d; 105 g, 85.26% yield) as a white solid. lH NMR (DMSO, 400 MHz) delta 4.23 (s, 3H). 13C-NMR (400MHz, DMSO) delta 160.86, 138.23, 124.52, 43.38. The synthetic route of 4,5-Dibromo-2-methyl-2H-1,2,3-triazole has been constantly updated, and we look forward to future research findings. Reference:
Patent; ASTRAZENECA AB; WARD, Richard, Andrew; JONES, Clifford, David; FERON, James, Lyman; (80 pag.)WO2017/80980; (2017); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 28938-17-2 as follows. Computed Properties of C3H3Br2N3

Example 21 1.20 g (5.0 mmol) of 2-methyl-4,5-dibromo-2H-1,2,3-triazole was dissolved in 10 ml of tetrahydrofuran, cooled to -20?0C, 2.74 ml (5.18 mmol) of 2.0M isopropylmagnesium tetrahydrofuran solution was added dropwise slowly in 30 minutes. Added dropwise was completed, continued to stir for 30?60 minutes. 1.26 g (5.0 mmol) of solid iodine was added, continued to react for 30 minutes. Reaction liquid was added by 20 ml of saturated ammonium chloride aqueous solution, extracted by using 30 ml of ethyl acetate, dried by anhydrous sodium sulfate, concentrated to dry under reduced pressure, the residual solid was added by 10 ml of isopropanol/water (5/1), heated to reflux for 1 hour, cooled to 0?10C, continued to be stirred for 1 hour, filtered, vacuum dried under a temperature <40C. 1.16 g of 2-methyl-4-bromo-5-iodo-2H-1,2,3-triazole solid was obtained, the yield was 81%. 1H NMR (CDCl3, 400 MHz): delta 4.20 (s, 3H); 13C NMR (CDCl3, 400 MHz): delta 130.4, 94.6, 43.0. According to the analysis of related databases, 28938-17-2, the application of this compound in the production field has become more and more popular. Reference:
Patent; ABA Chemicals Corporation; JIANG, Yueheng; QUE, Limin; CAI, Tong; QIN, Dongguang; EP2889292; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Some common heterocyclic compound, 28938-17-2, name is 4,5-Dibromo-2-methyl-2H-1,2,3-triazole, molecular formula is C3H3Br2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: Triazoles

4-bromo-2-methyl-2H-l,2,3-triazole. n-Butyllithium (8.3 mL) was added dropwise to a solution of 4,5-dibromo-2-methyl-2H-l,2,3-triazole (2.0 g, 8.37 mmol) in tetrahydrofuran (50 mL) under -78C, Once addition was completed, the mixture was stirred for another 30 minutes at -78C. The reaction was quenched with water, extracted with ethyl acetate (50 mL x 3), washed by brine (30 mL x 3). The organic phase was dried over anhydrous sodium sulfate and then filtered. The filtrate was concentrated in vacuo to afford 4-bromo-2-methyl-2H- 1,2,3- triazole.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 28938-17-2, its application will become more common.

Reference:
Patent; CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; GEHLING, Victor, S.; HEWITT, Michael, C.; TAYLOR, Alexander, M.; HARMANGE, Jean-Christophe; WO2012/151512; (2012); A2;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthetic Route of 28938-17-2,Some common heterocyclic compound, 28938-17-2, name is 4,5-Dibromo-2-methyl-2H-1,2,3-triazole, molecular formula is C3H3Br2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 1 3.0 g (12.45 mmol) of 2-methyl-4,5-dibromo-2H-1,2,3-triazole was dissolved in 25 ml of tetrahydrofuran, cooled to -20?-10C, 6.85 ml (13.7 mmol) of 2.0M isopropylmagnesium chloride tetrahydrofuran solution was added dropwise slowly in 30 minutes. Added dropwise was completed, continued to stir for 30?60 minutes. Chlorine was inleted slowly until reaction liquid was no longer heating up. Reaction liquid was added by 20 ml of saturated ammonium chloride aqueous solution, extracted by using 30 ml of methyl tertiary butyl ether, dried by anhydrous sodium sulfate, concentrated to dry under reduced pressure, the residual solid was added by 20 ml of methyl tertiary butyl ether/n-hexane (1/5), heated to reflux for 1 hour, cooled to 0?10C, continued to be stirred for 1 hour, filtered, vacuum dried under a temperature <40C. 2.06 g of 2-methyl-4-bromo-5-chloro-2H-1,2,3-triazole solid was obtained, the yield was 85%. 1H NMR (CDCl3, 400 MHz): delta 4.15 (s, 3H); 13C NMR (CDCl3, 400 MHz): delta 137.0, 120.8, 43.1. The synthetic route of 28938-17-2 has been constantly updated, and we look forward to future research findings. Reference:
Patent; ABA Chemicals Corporation; JIANG, Yueheng; QUE, Limin; CAI, Tong; QIN, Dongguang; EP2889292; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 28938-17-2 name is 4,5-Dibromo-2-methyl-2H-1,2,3-triazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 28938-17-2

4-bromo-2-methyl-2H-l,2,3-triazole. n-Butyllithium (8.3 mL) was added dropwise to a solution of 4,5-dibromo-2-methyl-2H-l,2,3-triazole (2.0 g, 8.37 mmol) in tetrahydrofuran (50 mL) under -78C, Once addition was completed, the mixture was stirred for another 30 minutes at -78C. The reaction was quenched with water, extracted with ethyl acetate (50 mL x 3), washed by brine (30 mL x 3). The organic phase was dried over anhydrous sodium sulfate and then filtered. The filtrate was concentrated in vacuo to afford 4-bromo-2-methyl-2H- 1,2,3- triazole.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4,5-Dibromo-2-methyl-2H-1,2,3-triazole, and friends who are interested can also refer to it.

Reference:
Patent; CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; GEHLING, Victor, S.; HEWITT, Michael, C.; TAYLOR, Alexander, M.; HARMANGE, Jean-Christophe; WO2012/151512; (2012); A2;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics