Category: 3641-13-2

Some common heterocyclic compound, 3641-13-2, name is 5-Amino-4H-1,2,4-triazole-3-carboxylic acid, molecular formula is C3H4N4O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 5-Amino-4H-1,2,4-triazole-3-carboxylic acid

3-Amino-1,2,4-triazole-5-carboxylic acid hydrate (1.28g, O.OImol) was dissolved in water (50ml). Sodium nitrite (0.76g, 0.011mol) was added and the solution was stirred until the sodium nitrite had dissolved. The mixture was then added dropwise to a cooled mix of ice-water (30g) and concentrated hydrochloric acid (3.0ml) at 0-5C. The mixture was stirred for 30 minutes at 0-5C and then excess nitrous acid was destroyed by the addition of sulfamic acid. The resultant diazonium salt suspension was added slowly to a solution of 6-hydroxyquinoline (1.45g, O.OImol) in water (100ml) at pH 8-9 (adjusted with 2M NaOH) and cooled to below 5C. The reaction mixture was then stirred at 0-5C for one hour and the product was precipitated by acidification to pH 4 with 2M HCI and collected by filtration. The product was washed with water and then dried in a vacuumdesiccator to give an orange solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3641-13-2, its application will become more common.

Reference:
Patent; AVECIA LIMITED; WO2004/108834; (2004); A2;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthetic Route of 3641-13-2, These common heterocyclic compound, 3641-13-2, name is 5-Amino-4H-1,2,4-triazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of benzil (0.01 mol), aldehydes (0.01 mol), 3-amino-1,2,4-triazole-5-carboxylic acid (0.01 mol), ammonium acetate (0.01 mol) and ceric ammonium nitrate (15 mol%) as a catalyst were refluxed in ethanol (15 mL) for about 3-4 h. The progress of the reaction was monitored by TLC. After completion of reaction, the mixture was cooled to room temperature. The solid formed was filtered and dried. The crude products were recrystallized by ethanol.

Statistics shows that 5-Amino-4H-1,2,4-triazole-3-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 3641-13-2.

Reference:
Article; Nikalje, Anna Pratima G.; Ghodke, Mangesh S.; Kalam Khan, Firoz A.; Sangshetti, Jaiprakash N.; Chinese Chemical Letters; vol. 26; 1; (2015); p. 108 – 112;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Electric Literature of 3641-13-2,Some common heterocyclic compound, 3641-13-2, name is 5-Amino-4H-1,2,4-triazole-3-carboxylic acid, molecular formula is C3H4N4O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of benzil (0.01 mol), aldehydes (0.01 mol), 3-amino-1,2,4-triazole-5-carboxylic acid (0.01 mol), ammonium acetate (0.01 mol) and ceric ammonium nitrate (15 mol%) as a catalyst were refluxed in ethanol (15 mL) for about 3-4 h. The progress of the reaction was monitored by TLC. After completion of reaction, the mixture was cooled to room temperature. The solid formed was filtered and dried. The crude products were recrystallized by ethanol.

The synthetic route of 3641-13-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Nikalje, Anna Pratima G.; Ghodke, Mangesh S.; Kalam Khan, Firoz A.; Sangshetti, Jaiprakash N.; Chinese Chemical Letters; vol. 26; 1; (2015); p. 108 – 112;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3641-13-2, name is 5-Amino-4H-1,2,4-triazole-3-carboxylic acid, A new synthetic method of this compound is introduced below., Quality Control of 5-Amino-4H-1,2,4-triazole-3-carboxylic acid

A mixture of benzil (0.01 mol), aldehydes (0.01 mol), 3-amino-1,2,4-triazole-5-carboxylic acid (0.01 mol), ammonium acetate (0.01 mol) and ceric ammonium nitrate (15 mol%) as a catalyst were refluxed in ethanol (15 mL) for about 3-4 h. The progress of the reaction was monitored by TLC. After completion of reaction, the mixture was cooled to room temperature. The solid formed was filtered and dried. The crude products were recrystallized by ethanol.

The synthetic route of 3641-13-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Nikalje, Anna Pratima G.; Ghodke, Mangesh S.; Kalam Khan, Firoz A.; Sangshetti, Jaiprakash N.; Chinese Chemical Letters; vol. 26; 1; (2015); p. 108 – 112;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application of 3641-13-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3641-13-2 name is 5-Amino-4H-1,2,4-triazole-3-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A mixture of benzil (0.01 mol), aldehydes (0.01 mol), 3-amino-1,2,4-triazole-5-carboxylic acid (0.01 mol), ammonium acetate (0.01 mol) and ceric ammonium nitrate (15 mol%) as a catalyst were refluxed in ethanol (15 mL) for about 3-4 h. The progress of the reaction was monitored by TLC. After completion of reaction, the mixture was cooled to room temperature. The solid formed was filtered and dried. The crude products were recrystallized by ethanol.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Amino-4H-1,2,4-triazole-3-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Article; Nikalje, Anna Pratima G.; Ghodke, Mangesh S.; Kalam Khan, Firoz A.; Sangshetti, Jaiprakash N.; Chinese Chemical Letters; vol. 26; 1; (2015); p. 108 – 112;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Related Products of 3641-13-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3641-13-2 as follows.

The organometallic complex [Mo(CO)3Br2(NCMe)2] was preparedaccording to literature methods [1,4,5]. A solution of Mo-II(2.3 g, 5.45 mmol) in ethanol (60 mL) was treated with 3-amino-1,2,4-triazole-5-carboxylic acid (ATZAc) (0.70 g, 5.45 mmol). Theresulting solutionwas stirred for 8 h under reflux and evaporated todryness. The solid obtained was washed with hexane and dried under vacuum (2.22 g of yield) [6]. Elemental Analysis forMoC7O3Br2N2H6 (421.94 g/mol): calculated C 19.90%, N 6.63%, H1.42%, Mo 22.73%; found C 19.76%, N 6.59%, H 1.31%, Mo 22.65%. IR(KBr pellet, cm-1): nu (?CO) =1879, 1974, 204, nu (C?O) =1679. EDS(Full scale 37854 ct cursor: -0.348 (octs), keV): C, N, O, Br, Mo.

According to the analysis of related databases, 3641-13-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Vieira, Eduardo Guimaraes; Dal-Bo, Alexandre Goncalves; Frizon, Tiago Elias Allievi; Dias Filho, Newton Luiz; Journal of Organometallic Chemistry; vol. 834; (2017); p. 73 – 82;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthetic Route of 3641-13-2, A common heterocyclic compound, 3641-13-2, name is 5-Amino-4H-1,2,4-triazole-3-carboxylic acid, molecular formula is C3H4N4O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 2 (Synthesis of Dye 12); A solution of sodium nitrite (7.59 g; 0.11 mol) in 25 ml water was added rapidly dropwise to a slurry of 3-amino-1,2,4-triazole-5-carboxylic acid (12.81 g; 0.1 mol) in 49 g concentrated HCl (37% aq.) and 100 ml water at 0-5 C. The mixture was stirred 90 minutes at 0-5 C. The resultant diazonium slurry was added rapidly dropwise during 15 minutes to a solution of N-(2- carboxyethyl)-5-aminoquinoline (21.62 g; 0.1 mol; prepared above) in 300 ml 20% aqueous sodium carbonate at 0 C and cooled in ice bath. The mixture was stirred 5 hours, slowly warming to room temperature as the ice bath melted. The pH of the slurry was adjusted to 6.0 with concentrated HCl (37% aq.). The resulting orange precipitate was filtered and then dried at 60 C (crude yield = 49.5 g). The crude product (42.9 g) was re-dissolved in 2000 ml water. Addition of solid nickel(II) acetate tetrahydrate (7.75 g; 0.031 mol) immediately afforded a bright magenta solution of Dye 12 (lambdamax = 525 nm). The dye solution was further purified by ultra-filtration prior to evaluation.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; LEXMARK INTERNATIONAL, INC.; EP1609823; (2005); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application of 3641-13-2, These common heterocyclic compound, 3641-13-2, name is 5-Amino-4H-1,2,4-triazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of 3-amino-1,2,4-triazole-5-carboxylic acid (ATZAc)(49.41 g, 385.7 mmol) in anhydrous dimethylformamide (300 mL)was added over a period of 50 min to a stirred solution of POSS-PrCl(25 g, 24.11 mmol) in 300mL of DMF. The temperaturewas allowedto rise to 160 C and stirring was continued for 48 h resulting in awhite solution. Ethanol was added to precipitate octa[3-amino-1,2,4-triazole-5-carboxylic acid) propyl] silsesquioxane. The precipitatewas separated by filtration and washed with ethanolresulting in the POSS-ATZAc, according to our previous work [4].The resulting product was obtained after several attempts.Elemental Analysis for Si8O28C48H72N32 (1768.8 g/mol): C 32.56%, N25.32%, H 4.07%; found C 32.49%, N 24.95%, H 4.00%. IR (KBr pellet,cm-1): nu (C-H)=2939, nu (CO) =704, nu (CN) =1600, nu (CN)=1446, nuas (Si-O-Si) =1112. 13C solid-state NMR (100.61 MHz,ppm): 9.64 (CH2-Si), 23.23 (CH2-CH2Si), 48.95 (CH2-N),140.66-149.40 (aromatic ring), 155.22 (carboxylic acid group). 29Sisolid-state NMR (79.48 MHz, (Si-O), ppm): 66.04 (highintensity), 58.04 (low intensity). EDS (Full scale 58029 ctcursor: 0.152 (octs), keV): C, N, O, Si.

Statistics shows that 5-Amino-4H-1,2,4-triazole-3-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 3641-13-2.

Reference:
Article; Vieira, Eduardo Guimaraes; Dal-Bo, Alexandre Goncalves; Frizon, Tiago Elias Allievi; Dias Filho, Newton Luiz; Journal of Organometallic Chemistry; vol. 834; (2017); p. 73 – 82;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Some common heterocyclic compound, 3641-13-2, name is 5-Amino-4H-1,2,4-triazole-3-carboxylic acid, molecular formula is C3H4N4O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 5-Amino-4H-1,2,4-triazole-3-carboxylic acid

General procedure: A mixture of benzil (0.01 mol), aldehydes (0.01 mol), 3-amino-1,2,4-triazole-5-carboxylic acid (0.01 mol), ammonium acetate (0.01 mol) and ceric ammonium nitrate (15 mol%) as a catalyst were refluxed in ethanol (15 mL) for about 3-4 h. The progress of the reaction was monitored by TLC. After completion of reaction, the mixture was cooled to room temperature. The solid formed was filtered and dried. The crude products were recrystallized by ethanol.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3641-13-2, its application will become more common.

Reference:
Article; Nikalje, Anna Pratima G.; Ghodke, Mangesh S.; Kalam Khan, Firoz A.; Sangshetti, Jaiprakash N.; Chinese Chemical Letters; vol. 26; 1; (2015); p. 108 – 112;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3641-13-2, name is 5-Amino-4H-1,2,4-triazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C3H4N4O2

General procedure: A mixture of benzil (0.01 mol), aldehydes (0.01 mol), 3-amino-1,2,4-triazole-5-carboxylic acid (0.01 mol), ammonium acetate (0.01 mol) and ceric ammonium nitrate (15 mol%) as a catalyst were refluxed in ethanol (15 mL) for about 3-4 h. The progress of the reaction was monitored by TLC. After completion of reaction, the mixture was cooled to room temperature. The solid formed was filtered and dried. The crude products were recrystallized by ethanol.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3641-13-2.

Reference:
Article; Nikalje, Anna Pratima G.; Ghodke, Mangesh S.; Kalam Khan, Firoz A.; Sangshetti, Jaiprakash N.; Chinese Chemical Letters; vol. 26; 1; (2015); p. 108 – 112;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics