Category: 3641-13-2

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3641-13-2 as follows. Quality Control of 5-Amino-4H-1,2,4-triazole-3-carboxylic acid

0.2mmol, 0.0252g H2atrc, 0.2mmol, 0.0389g 4,4?-bipy and 0.2mmol, 0.0520g CdSO4¡¤8/3H2O mixed with 10mL H2O and 5mL EtOH were placed in a 25mL Teflon-lined stainless-steel autoclave. The mixture was kept inside a furnace at 110C for 5 days, and then naturally cooled to ambient temperature. The colorless platelet crystals of 1 suitable for X-ray diffraction were collected after soak clearing with water and ethanol. Yield based on Hatrz: 23.1mg, 39.48%. IR data (in KBr, cm-1) for 1: 3428(m), 3339(m), 3268(w), 3204(w), 3147(w), 2987(w), 2859(w), 1643(m), 1592(m), 1528(w), 1413(w), 1362(w), 1278(w), 1125(s), 1055(m), 882(w), 805(w), 600(w), 460(w).

According to the analysis of related databases, 3641-13-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Liu, Bing; Feng, Hui-Jun; Zhang, Zong-Hui; Xu, Ling; Jiao, Huan; Journal of Molecular Structure; vol. 1098; (2015); p. 240 – 245;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application of 3641-13-2,Some common heterocyclic compound, 3641-13-2, name is 5-Amino-4H-1,2,4-triazole-3-carboxylic acid, molecular formula is C3H4N4O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of benzil (0.01 mol), aldehydes (0.01 mol), 3-amino-1,2,4-triazole-5-carboxylic acid (0.01 mol), ammonium acetate (0.01 mol) and ceric ammonium nitrate (15 mol%) as a catalyst were refluxed in ethanol (15 mL) for about 3-4 h. The progress of the reaction was monitored by TLC. After completion of reaction, the mixture was cooled to room temperature. The solid formed was filtered and dried. The crude products were recrystallized by ethanol.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Amino-4H-1,2,4-triazole-3-carboxylic acid, its application will become more common.

Reference:
Article; Nikalje, Anna Pratima G.; Ghodke, Mangesh S.; Kalam Khan, Firoz A.; Sangshetti, Jaiprakash N.; Chinese Chemical Letters; vol. 26; 1; (2015); p. 108 – 112;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application of 3641-13-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3641-13-2, name is 5-Amino-4H-1,2,4-triazole-3-carboxylic acid belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below.

2-(((3R,4S)-3-fluoropiperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile (70 mg, 0.13 mmol), HATU (100 mg, 0.26 mmol), DIEA (52 mg, 0.4 mmol) and 3-amino-1H-1,2,4-triazole-5-carboxylic acid (34 mg, 0.26 mmol) were dissolved in DMF (4 mL) and stirred at room temperature for 2 hr. The mixture was diluted with DCM and extracted with water. The organic phase was dried over Na2SO4 and concentrated. The residue was purified silica gel column with ESCO system with 5-20% MeOH in CH2Cl2 to give the title compound. 1H NMR (400 MHz, DMSO-d6) delta 12.33 (d, J=7.3 Hz, 1H), 10.12 (d, J=22.3 Hz, 1H), 8.81-8.66 (m, 1H), 8.66-8.42 (m, 2H), 7.71-7.34 (m, 3H), 6.95 (t, J=9.2 Hz, 2H), 6.15 (s, 1H), 5.26-4.85 (m, 2H), 4.51 (m, 4H), 4.17 (s, 1H), 3.73 (m, 1H), 3.60 (m, 1H), 3.45 (m, 1H), 3.12 (m, 4H), 2.41 (m, 4H), 2.12-1.79 (m, 2H). LCMS-ESI+ (m/z): [M+H]+ calcd for C31H33FN12O3: 641.3. found: 641.4

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Amino-4H-1,2,4-triazole-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Gilead Sciences, Inc.; Du, Zhimin; Guerrero, Juan A.; Kaplan, Joshua A.; Knox, JR., John E.; Lo, Jennifer R.; Mitchell, Scott A.; Naduthambi, Devan; Phillips, Barton W.; Venkataramani, Chandrasekar; Wang, Peiyuan; Watkins, William J.; Zhao, Zhongdong; (593 pag.)US2016/96827; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Related Products of 3641-13-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3641-13-2 name is 5-Amino-4H-1,2,4-triazole-3-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A mixture of benzil (0.01 mol), aldehydes (0.01 mol), 3-amino-1,2,4-triazole-5-carboxylic acid (0.01 mol), ammonium acetate (0.01 mol) and ceric ammonium nitrate (15 mol%) as a catalyst were refluxed in ethanol (15 mL) for about 3-4 h. The progress of the reaction was monitored by TLC. After completion of reaction, the mixture was cooled to room temperature. The solid formed was filtered and dried. The crude products were recrystallized by ethanol.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Amino-4H-1,2,4-triazole-3-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Article; Nikalje, Anna Pratima G.; Ghodke, Mangesh S.; Kalam Khan, Firoz A.; Sangshetti, Jaiprakash N.; Chinese Chemical Letters; vol. 26; 1; (2015); p. 108 – 112;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics