Related Products of 3641-14-3, These common heterocyclic compound, 3641-14-3, name is Methyl 5-Amino-1,2,4-triazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1 : Methyl 5-bromo-1 /–1.2.4-triazole-3-carboxylate (306a) Methyl 5-amino-1 H-1 ,2,4-triazole-3-carboxylate (6.5 g, 45 mmol) was suspended in a mixture of cone. H2S04 (6 ml_) and water (100 ml_). Then an aq. solution of NaN02 (6.4 g, 67 mmol) was added to the suspension at -3C. After 30 min at -3C a freshly prepared aq. solution of CuBr (4.2 g, 21 mmol) and KBr (13.0 g, 91 mmol) was added dropwise. After stirring for 3 h at 25C the mixture was extracted with EA. The crude product was purified by CC (DCM/CH3OH = 20/1) to give compound 306a (5.5 g, 58%) as a white solid.
The synthetic route of 3641-14-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PHENEX PHARMACEUTICALS AG; GEGE, Christian; KINZEL, Olaf; STEENECK, Christoph; KLEYMANN, Gerald; HOFFMANN, Thomas; WO2014/23367; (2014); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics