Category: 40594-98-7

Synthesis and investigation of tuberculosis inhibition activities of some 1,2,3-triazole derivatives was written by Dabak, Kadir;Sezer, Ozkan;Akar, Ahmet;Anac, Olcay. And the article was included in European Journal of Medicinal Chemistry in 2003.Category: triazoles This article mentions the following:

In this study, 浼?diazo-灏?oxoaldehyde compounds were condensed with different amines to yield 4-acyl-1H-1,2,3-triazole derivatives The 1,2,3-triazole compounds were investigated for their inhibition activities against tuberculosis. In the experiment, the researchers used many compounds, for example, Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7Category: triazoles).

Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7) belongs to triazole derivatives. The triazole ring is a relatively stable functional group, and the triazole bond can be used for a variety of applications, such as replacing the phosphate backbone of DNA. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeCategory: triazoles

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

6-(Substituted methylene)penems, potent broad-spectrum inhibitors of bacterial β-lactamase. V. Chiral 1,2,3-triazolyl derivatives was written by Bennett, Isabel S.;Brooks, Gerald;Broom, Nigel J. P.;Calvert, Stephen H.;Coleman, Kenneth;Francois, Irene. And the article was included in Journal of Antibiotics in 1991.SDS of cas: 40594-98-7 This article mentions the following:

A series of (5R)-6-triazolylmethylenepenems I [R = H, Me, Et, Pr, CF₃CH₂, NaO₂CCH₂, Me₂N, MeO, HO, HOCH₂CH₂, HO(CH₂)₃, cyclopropyl] with potent β-lactamase inhibitory activity were prepared and their structure-activity relationships determined In most cases, their in vitro synergistic activity with amoxycillin is superior to that of clavulanic acid, sulbactam and tazobactam. Against an Escherichia coli TEM-1 infection in mice, I showed a broad range of potencies; an optimum polarity was found, however, which gave maximum potency. In the experiment, the researchers used many compounds, for example, Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7SDS of cas: 40594-98-7).

Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7) belongs to triazole derivatives. Triazoles consist of a five-membered ring containing three nitrogen atoms and are biologically active, especially as antifungal, antimicrobial and enzyme inhibitors. Both the triazoles and their derivatives have significant biological properties including antimicrobial, antiviral, antitubercular, anticancer, anticonvulsant, analgesic, antioxidant, anti-inflammatory, and antidepressant activities.SDS of cas: 40594-98-7

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Syntheses of D-arabinofuranosyl and 2′-deoxy-D-ribofuranosyl 1,2,3-triazolecarboxamides was written by Makabe, Osamu;Suzuki, Hiroshi;Umezawa, Sumio. And the article was included in Bulletin of the Chemical Society of Japan in 1977.Recommanded Product: 40594-98-7 This article mentions the following:

Several D-arabino- and 2′-deoxy-D-ribonucleosides of 1,2,3-triazolecarboxamides were synthesized by 2 methods, one involving acid-catalyzed fusion reactions of 1-O-acetyl-2,3,5-tri-O-benzyl-D-arabinofuranose or 1-O-acetyl-3,5-di-O-(p-nitrobenzoyl)-D-2-deoxyribofuranose with Et 1,2,3-triazole-4-carboxylate (I), and the other by glycosylation of the trimethylsilyl derivative of I with 2,3,5-tri-O-benzyl-D-arabinofuranosyl chloride or 3,5-di-O-(p-toluoyl)-D-2-deoxyribofuranosyl chloride. Evidence for the N-glycosylation sites (1 or 2 of triazole) and anomeric configurations of the resulting nucleosides is presented. Of the compounds prepared nucleosides II (R = H, OH) showed antiviral and cytotoxic activities (no data). In the experiment, the researchers used many compounds, for example, Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7Recommanded Product: 40594-98-7).

Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7) belongs to triazole derivatives. The many free lone pairs in triazoles make them useful as coordination compounds, although not typically as haptic ligands. The presence of the three nitrogen atoms in triazole structures afforded opportunities for a plethora of structural modification with the generation of novel therapeutically potential agents, which is different from other heterocyclic compounds.Recommanded Product: 40594-98-7

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies was written by Bezencon, Olivier;Heidmann, Bibia;Siegrist, Romain;Stamm, Simon;Richard, Sylvia;Pozzi, Davide;Corminboeuf, Olivier;Roch, Catherine;Kessler, Melanie;Ertel, Eric A.;Reymond, Isabelle;Pfeifer, Thomas;de Kanter, Ruben;Toeroek-Schafroth, Michael;Moccia, Luca G.;Mawet, Jacques;Moon, Richard;Rey, Markus;Capeleto, Bruno;Fournier, Elvire. And the article was included in Journal of Medicinal Chemistry in 2017.Recommanded Product: 40594-98-7 This article mentions the following:

The authors report the discovery and pharmacol. characterization of N-(1-benzyl-1H-pyrazol-3-yl)-2-phenylacetamide derivatives as potent, selective, brain-penetrating T-type calcium channel blockers. Optimization focused mainly on solubility, brain penetration, and the search for an aminopyrazole metabolite that would be neg. in an Ames test. This resulted in the preparation and complete characterization of compound 66b (ACT-709478 (N-(1-((5-cyanopyridin-2-yl)methyl)-1H-pyrazol-3-yl)-2-(4-(1-(trifluoromethyl)cyclopropyl)phenyl)acetamide)), which has been selected as a clin. candidate. In the experiment, the researchers used many compounds, for example, Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7Recommanded Product: 40594-98-7).

Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7) belongs to triazole derivatives. Triazoles exhibit substantial isomerism, depending on the positioning of the nitrogen atoms within the ring. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeRecommanded Product: 40594-98-7

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Reaction of aluminum azide with cyanoesters. Preparation of tetrazolo[1,5-c]pyrimidin-5(6H)-one and tetrazolo[1,5-c]quinazolin-5(6H)-one was written by Wagner, Eugene R.. And the article was included in Journal of Organic Chemistry in 1973.Name: Ethyl 1H-1,2,3-triazole-5-carboxylate This article mentions the following:

The reaction of Al(N3)3 with a variety of unsaturated β-cyano esters was studied. Both cis- and trans-3-cyanoacrylates gave trans-3-tetrazole-5-acrylate. trans-3-Cyanocrotonate gave trans-3-methyltetrazole-5-acrylate, while cis-3-cyanocrotonate gave a mixture consisting mainly of 1-(2-cyanopropenyl)tetrazolin-5(4H)-one and tetrazolo[1,5-c]pyrimidin-5-(6H)-one. The reaction of Al(N3)3 and Et o-cyanobenzoate gave a mixture of tetrazolo[1,5-c]quinazolin-5(6H)-one, 1-[o-(tetrazol-5-yl)phenyl]-tetrazolin-5(4H)-one, Et o-(5-tetrazolyl)benzoate, and o-(5-oxo-2-tetrazolin-1-yl)benzonitrile. The formation of the quinazolinone via a Curtius rearrangement is proposed. In the experiment, the researchers used many compounds, for example, Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7Name: Ethyl 1H-1,2,3-triazole-5-carboxylate).

Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeName: Ethyl 1H-1,2,3-triazole-5-carboxylate

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Diazo aldehyde chemistry. Part 3. synthesis of 4-acyl-1H-1,2,3-triazole derivatives was written by Sezer, Oezkan;Dabak, Kadir;Akar, Ahmet;Anac, Olcay. And the article was included in Helvetica Chimica Acta in 1996.Computed Properties of C5H7N3O2 This article mentions the following:

Ten α-diazo-β-oxo aldehydes were condensed with PhNH₂, NH₃, NH₂OH, and NH₂CONHNH₂ to yield 1-substituted 4-acyl-1H-1,2,3-triazoles in moderate to good yields. The method is simple and regiospecific. Thus, it is superior to the widely used acylacetylene and azide approach. In the experiment, the researchers used many compounds, for example, Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7Computed Properties of C5H7N3O2).

Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules.Computed Properties of C5H7N3O2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics