Category: 4546-95-6

Syntheses and crystal structures of copper(II) and nickel complexes with 1,2,3-triazole-carboxylic acid was written by Wang, Duo-Zhi;Bai, Mei;Zhang, Jian-Bin;Ma, Peng-Yuan. And the article was included in Chinese Journal of Structural Chemistry in 2012.Safety of 1H-1,2,3-Triazole-4,5-dicarboxylic acid This article mentions the following:

Three novel complexes [Cu(L¹)₂(H₂O)₂] (1), [Ni(L¹)₂(H₂O)₂]·(H₂O)₄ (2, HL¹ = 5-methyl-1-(4-methylphenyl)-1,2,3-triazole-4-carboxylic acid) and [Ni₂(HL²)₂(CH₃OH)₆]·(CH₃OH)₂ (3, H₃L² = 1,2,3-triazole-4,5-dicarboxylic acid) were synthesized and characterized by elemental anal., IR and x-ray diffraction. Complexes 1 and 2 are mononuclear structures, and are assembled into a two-dimensional sheet by C(7)-H(7)···O(3) weak interactions or hydrogen-bonding interaction. Complex 3 is a centrosym. dinuclear structure, and is assembled into a three-dimensional supramol. structure by hydrogen-bonding interaction. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Safety of 1H-1,2,3-Triazole-4,5-dicarboxylic acid).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Triazoles consist of a five-membered ring containing three nitrogen atoms and are biologically active, especially as antifungal, antimicrobial and enzyme inhibitors. The presence of the three nitrogen atoms in triazole structures afforded opportunities for a plethora of structural modification with the generation of novel therapeutically potential agents, which is different from other heterocyclic compounds.Safety of 1H-1,2,3-Triazole-4,5-dicarboxylic acid

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

catena-Poly[(chloridozinc)-μ-5-(1-methyl-1H-benzimidazol-2-yl-κN³)-1,2,3-triazol-1-ido-κ²N¹:N³] was written by Sun, Chen-Guang;Song, Ji-Rong. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2012.Application In Synthesis of 1H-1,2,3-Triazole-4,5-dicarboxylic acid This article mentions the following:

In the title complex, [Zn(C₁₀H₈N₅)Cl]_n, the Zn^II ion is four-coordinated by one Cl atom and three N atoms from two in situ-generated deprotonated 5-(1-methyl-1H-benzimidazol-2-yl-κN³)-1,2,3-triazol-1-ide ligands in a slightly distorted tetrahedral geometry. The Zn^II ions are bridged by the ligands, forming a helical chain along [001]. C-H···N and C-H···Cl H bonds and π-π interactions between the imidazole rings [centroid-centroid distance = 3.4244(10) Å] assemble the chains into a three-dimensional supramol. network. Crystallog. data and at. coordinates are given. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Application In Synthesis of 1H-1,2,3-Triazole-4,5-dicarboxylic acid).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.Application In Synthesis of 1H-1,2,3-Triazole-4,5-dicarboxylic acid

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Virtual Combinatorial Syntheses and Computational Screening of New Potential Anti-Herpes Compounds was written by de Julian-Ortiz, Jesus V.;Galvez, Jorge;Munoz-Collado, Carlos;Garcia-Domenech, Ramon;Gimeno-Cardona, Concepcion. And the article was included in Journal of Medicinal Chemistry in 1999.HPLC of Formula: 4546-95-6 This article mentions the following:

The activity of new anti-HSV-1 chem. structures, designed by virtual combinatorial chem. synthesis and selected by a computational screening, is determined by an in vitro assay. A virtual library of phenol esters and anilides was formed from two databases of building blocks: one with carbonyl fragments and the other containing both substituted phenoxy and phenylamino fragments. The library of virtually assembled compounds was computationally screened, and those compounds which were selected by our math. model as active ones were finally synthesized and tested. Our antiviral activity model is a “tandem” of four linear functions of topol. graph-theor. descriptors. A given chem. structure was selected as active if it satisfies every discriminant equation in that model. The final result was that five new structures were selected, synthesized, and tested: all of them demonstrated activity, and three showed appreciable anti-HSV-1 activity, with IC₅₀ values of 0.9 μM. The same model, applied to a database of known compounds, has identified the anti-herpes activity of the following compounds: 3,5-dimethyl-4-nitroisoxazole, nitrofurantoin, 1-(pyrrolidinocarbonylmethyl)piperazine, nebularine, cordycepin, adipic acid, thymidine, α-thymidine, inosine, 2,4-diamino-6-(hydroxymethyl)pteridine, 7-(carboxymethoxy)-4-methylcoumarin, 5-methylcytidine, and others that showed less activity. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6HPLC of Formula: 4546-95-6).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. Many triazoles have antifungal effects: the triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole and triazole plant-protection fungicides include epoxiconazole, triadimenol, myclobutanil, propiconazole, prothioconazole, metconazole, cyproconazole, tebuconazole, flusilazole and paclobutrazol.HPLC of Formula: 4546-95-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

3,4-Diamino-1,2,4-triazole based energetic salts: synthesis, characterization, and energetic properties was written by Wu, Jin-Ting;Zhang, Jian-Guo;Yin, Xin;Cheng, Zi-Yuan;Xu, Cai-Xia. And the article was included in New Journal of Chemistry in 2015.Synthetic Route of C4H3N3O4 This article mentions the following:

The protonation or metathesis synthesis and energetic properties of a new class of energetic materials, energetic salts of 3,4-diamino-triazole (DATr), are described. They were characterized by Fourier transform IR spectroscopy (FT-IR), elemental anal. (EA), differential scanning calorimetry (DSC), and X-ray single-crystal diffraction. The DSC results showed that these salts had acceptable thermal stabilities; the decomposition temperatures of these salts, except compound 3,4-Diamino-1,2,4-triazoliumnitro-formate, were over 200°. The d. of the series of salts ranged from 1.704 (3,4-Diamino-1,2,4-triazolium nitrate and 3,4-Diamino-1,2,4-triazolium picrate)-1.82 g cm^-3 (3,4-Diamino-1,2,4-triazolium trinitrophloroglucinate), placing them in a class of relatively dense compounds, and the heats of formation were calculated with the Gaussian 03 suite of programs. All the salts except 3,4-Diamino-1,2,4-triazolium 4,5-dicarboxylic-1,2,3-triazolate exhibited promising detonation performances (detonation pressure: 21.5-32.8 GPa, detonation velocity: 7017-8620 m s^-1), which were much higher than both those of TNT, and salt 3,4-Diamino-1,2,4-triazoliumnitro-formate was even comparable to RDX. Impact sensitivities were also determined by hammer tests and the results ranged from 8 J (sensitive) to > 40 J (insensitive). In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Synthetic Route of C4H3N3O4).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.Synthetic Route of C4H3N3O4

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Rapid and selective detection of aluminum ion using 1,2,3-triazole-4,5-dicarboxylic acid-functionalized gold nanoparticle-based colorimetric sensor was written by Zhao, Shengliang;Chen, Liqiong;Liu, Feiyan;Fan, Yongyao;Liu, Yiheng;Han, Yulai;Hu, Yunfei;Su, Jingyun;Song, Chunyan. And the article was included in RSC Advances in 2021.Recommanded Product: 1H-1,2,3-Triazole-4,5-dicarboxylic acid This article mentions the following:

A highly selective, sensitive, rapid, low-cost, simple and visual colorimetric system for Al³⁺ ion detection was developed based on gold nanoparticles (AuNPs) modified with 1,2,3-triazole-4,5-dicarboxylic acid (TADA). The modified gold nanoparticles (TADA-AuNPs) were first prepared by sodium citrate (Na₃Ct) reduction of chloroauric acid (HAuCl₄) and then capped with a TADA ligand. Five TADA-AuNPs sensors were constructed with sodium citrate (Na₃Ct)/chloroauric acid (HAuCl₄) under different molar ratios. Results showed that the molar ratio of Na₃Ct/HAuCl₄, TADA-AuNPs concentration, pH range and detection time had obvious influences on the performance of this colorimetric method. The optimal detection conditions for Al³⁺ ions were as follows: Na₃Ct/HAuCl₄ molar ratio of 6.4 : 1, 0.1 mM of TADA-AuNPs concentration, 4-10 pH range and 90 s of detection time. Under the optimal conditions and using di-Ph carbazone (DPC) as a Cr³⁺ masking agent, this colorimetric sensor exhibited outstanding time efficiency, selectivity and sensitivity for Al³⁺ detection. In particular, the detection limits of this sensor obtained via UV-vis and the naked eye were 15 nM and 1.5μM, resp., which were much lower than the current limit (3.7μM) for drinking water in WHO regulation and better than the previous reports. Moreover, this colorimetric sensing system could be used to for on-site, trace level and real-time rapid detection of Al³⁺ in real water samples. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Recommanded Product: 1H-1,2,3-Triazole-4,5-dicarboxylic acid).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.Recommanded Product: 1H-1,2,3-Triazole-4,5-dicarboxylic acid

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

A luminescent novel octanuclear silver(I) cluster framework with potential Cr₂O₇^2- sensing was written by Jin, Jun-Cheng;Jiang, Chen;Chang, Wen-Gui;Xu, Guang-Nian;Fu, Xu-Cheng. And the article was included in Inorganic Chemistry Communications in 2016.Recommanded Product: 1H-1,2,3-Triazole-4,5-dicarboxylic acid This article mentions the following:

An unique and novel octanuclear silver(I) cluster compound, [Ag₈(ADC)₄]_n (1) (H₂ADC = 1,3-adamantanedicarboxylic acid), was synthesized and characterized. Compound 1 exhibits significant Ag-Ag interactions to form 2-dimensional infinite silver layers with multiple unsaturated Ag atoms. Also, Luminescent studies show that 1 can exhibit highly selective response to Cr₂O₇^2- through luminescence quenching effect in aqueous solution, which make its good candidate as luminescent sensor. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Recommanded Product: 1H-1,2,3-Triazole-4,5-dicarboxylic acid).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. The many free lone pairs in triazoles make them useful as coordination compounds, although not typically as haptic ligands. Both the triazoles and their derivatives have significant biological properties including antimicrobial, antiviral, antitubercular, anticancer, anticonvulsant, analgesic, antioxidant, anti-inflammatory, and antidepressant activities.Recommanded Product: 1H-1,2,3-Triazole-4,5-dicarboxylic acid

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthesis and characterization of a novel one-dimensional Zn(II) coordination polymer based on in situ generated 1-methyl-2-(3H-[1,2,3]triazol-4-yl)-1H-benzoimidazole was written by Sun, Chen-guang;Xu, Kang-zhen;Yin, Zheng;Song, Ji-rong;Zeng, Ming-hua. And the article was included in Inorganic Chemistry Communications in 2012.Application of 4546-95-6 This article mentions the following:

One novel 1-dimensional chain of {[Zn₂(L)₃(H₂O)(NO₃)]·2.5H₂O}_n (1)(HL = 1-methyl-2-(3H-[1,2,3]triazol-4-yl)-1H-benzoimidazole) was hydrothermally constructed from in situ generated 1-methyl-2-(3H-[1,2,3]triazol-4-yl)-1H-benzoimidazole ligand at 160°. Compound 1 exhibits a 1-dimensional butterfly-like chain architecture, which is further assembled into a 3-dimensional supermol. network by interchain H bonds. TGA studies show that compound 1 is highly thermally stable. The fluorescent property in the solid state is also explored, and the emission spectrum shows a blue shift of 62 nm compared with that of HL, which may be assigned to ligand-to-metal charge transfer. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Application of 4546-95-6).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Application of 4546-95-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthesis and characterization of a novel one-dimensional Zn(II) coordination polymer based on in situ generated 1-methyl-2-(3H-[1,2,3]triazol-4-yl)-1H-benzoimidazole was written by Sun, Chen-guang;Xu, Kang-zhen;Yin, Zheng;Song, Ji-rong;Zeng, Ming-hua. And the article was included in Inorganic Chemistry Communications in 2012.Application of 4546-95-6 This article mentions the following:

One novel 1-dimensional chain of {[Zn₂(L)₃(H₂O)(NO₃)]·2.5H₂O}_n (1)(HL = 1-methyl-2-(3H-[1,2,3]triazol-4-yl)-1H-benzoimidazole) was hydrothermally constructed from in situ generated 1-methyl-2-(3H-[1,2,3]triazol-4-yl)-1H-benzoimidazole ligand at 160°. Compound 1 exhibits a 1-dimensional butterfly-like chain architecture, which is further assembled into a 3-dimensional supermol. network by interchain H bonds. TGA studies show that compound 1 is highly thermally stable. The fluorescent property in the solid state is also explored, and the emission spectrum shows a blue shift of 62 nm compared with that of HL, which may be assigned to ligand-to-metal charge transfer. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Application of 4546-95-6).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Application of 4546-95-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics