Category: 4928-88-5

Application of 4928-88-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4928-88-5 name is Methyl 1H-1,2,4-triazole-3-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In a 250 mL four-necked flask equipped with a mechanical stirrer, thermometer and distillation apparatus, 100.0 g of tetraacetyl ribose was added and heated to 100 ¡ã C in an oil bath.After the tetraacetyl ribose is completely melted into a transparent liquid, the stirring is started.40.0 g of methyl 1,2,4-triazolecarboxylate was added, and the two materials were uniformly mixed.Add 1.4g of elemental iodine, continue to raise the temperature to 115 ¡ã C, and keep warm for 2 hours.Then, vacuuming was started, and by-product acetic acid was distilled off; after 1 hour, the reaction was stopped, and the mixture was cooled to 70 ¡ã C or lower, 100 mL of methanol was taken, and the mixture was added to the flask, and the mixture was stirred to uniformly dissolve the material, and poured into a beaker. Allow to cool to room temperature,Precipitate solids, filter, wash, dry,Ribavirin intermediate[1-(2,3,5-Tri-O-acetyl-beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxylic acid methyl ester], yield 82percent (Based on tetraacetyl ribose, the same below.)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 1H-1,2,4-triazole-3-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; Henan Academy Of Sciences High Technology Research Center; Zhang Jiaxiang; Guo Xiaozhan; Chen Tiantian; Wang Huafen; Ren Zhiyong; Gong Wei; Fu Yang; Jiang Lei; (10 pag.)CN109336937; (2019); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application of 4928-88-5,Some common heterocyclic compound, 4928-88-5, name is Methyl 1H-1,2,4-triazole-3-carboxylate, molecular formula is C4H5N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 6000 ml 4-necked anhydrous reactor equipped with a thermometer, a condenser and a mechanical stirrer, 1680 ml of dichloromethane, 400.05 g of tetraacetyl ribose and 185.11 g of 3-carbomethoxytriazole were added while stirring and introducing nitrogen. The mixture was cooled to about 5 ¡ã C and 360.03 g of tin tetrachloride was added to the suspension as a trickle while stirring, and the reaction was allowed to exotherm by cooling with an ice bath so that the temperature did not exceed 15-20 ¡ãC, and when fully added, the reaction mixture was heated to reflux for 2 h, cooled to 20 ¡ã C with water and ice bath over 15 min.Then 30percent hydrochloric acid (176.7 ml) and water (1503.3 ml) were added at a temperature below +20 ¡ã C and stirred for 45 min; the mixture was allowed to stand for 15 min to separate, and then the aqueous phase of the upper layer was separated from the enriched organic phase, followed by The organic phase was treated with 30percent hydrochloric acid (176.7 ml) and water (1503.3 ml).After stirring for 45 min, the mixture was allowed to stand for 15 min to separate the phases, the upper aqueous phase was separated from the enriched organic phase, and then the organic phase was treated with 30percent hydrochloric acid (176.7 ml) and water (1503.3 ml). After 45 minutes,The mixture was allowed to stand for 15 min to separate the phases by phase separation: the organic phase was distilled at atmospheric pressure (internal temperature 45 ¡ã C) and 3000 ml of toluene was added to the oil residue, and the mixture was distilled under vacuum at a residual pressure of about 200 mbar. Stirred moist paste.It was allowed to cool to 5-10 ¡ã C for 2 h and was filtered on a Buchner funnel while washing with toluene. 521.36 g of a moist product were obtained.

The synthetic route of 4928-88-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Li Shuangxi; (12 pag.)CN109134565; (2019); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application of 4928-88-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4928-88-5 as follows.

EXAMPLE 5 Preparation of Methyl 1-(2,3,5-tri-O-Acetyl-beta-L-ribofuranosyl)-1,2,4-triazole-3-carboxylate From Alpha-1,2,3,5-tetra-O-acetyl-L-ribofuranose [0047] A 250 mL flask was charged with [0048] 1.92 g of triazolemethylester and a solution of [0049] 4.8 g of the pure alpha-1,2,3,5-tetra-O-acetyl-L-ribofuranose, prepared in Example 4 in [0050] 50 mL of methyl acetate. The mixture was concentrated at atmospheric pressure to almost dryness (bath temperature: 90¡ã C.). To this mixture was added a solution of [0051] 22.7 mg of triflic acid in 1 mL of methyl acetate. The mixture was stirred at 115+/-5¡ã C. (pot temperature) under vacuum (30 mbar) for 4 h. Upon the completion of the reaction the mixture was cooled to 70¡ã C. and to it was added [0052] 23 mL of 2B alcohol (ethyl alcohol). When a homogeneous solution was formed the mixture was cooled to 50¡ã C. and held until heavy precipitation formed. The mixture was then slowly cooled to -5¡ã C. (bath temperature) in 2 h and held for 13 h. The solid was filtered, washed with [0053] 20 mL of cold 2B Alcohol (ethyl alcohol), and dried under vacuum at 50¡ã C. for 17 h to give 4.1 g (70percent yield) of methyl 1-(2,3,5-tri-O-acetyl-beta-L-ribofuranosyl)-1,2,4-triazole-3-carboxylate as an off-white solid.

According to the analysis of related databases, 4928-88-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Dong, Zhiming; Zhang, Pingsheng; US2004/34213; (2004); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 4928-88-5, name is Methyl 1H-1,2,4-triazole-3-carboxylate, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4928-88-5, COA of Formula: C4H5N3O2

To a cooled (0 oC) solution of methyl 1H-1,2,4-triazole-3-carboxylate (36 g, 283.2 mmol, 1.0 equiv) in pyridine(300mL) was added triphenylmethyl chloride (85 g, 304.9 mmol, 1.1 equiv) and the suspension was stirred for 90 min at room temperature. Then the suspension was then heated at 100 oC and refluxed for 2h. The clear solution was cooled to room temperature and concentrated under vacuum. Isopropanol (500 mL) was added to the residue and the solid was filtered and washed with 3x 300 mL H2O. The solid was dried in an oven under reduced pressure to afford 85 g of the title compound as a white solid. LCMS ES+ 243 [M+H]+ (Trityl fragment).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 1H-1,2,4-triazole-3-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BRONNER, Sarah M.; CRAWFORD, James J.; CRIDLAND, Andrew; CYR, Patrick; FAUBER, Benjamin; GANCIA, Emanuela; GOBBI, Alberto; HURLEY, Christopher; KILLEN, Jonathan; LEE, Wendy; RENE, Olivier; VAN NIEL, Monique Bodil; WARD, Stuart; WINSHIP, Paul; ZBIEG, Jason; (439 pag.)WO2018/83105; (2018); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthetic Route of 4928-88-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4928-88-5 name is Methyl 1H-1,2,4-triazole-3-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

1-(1-Ethoxyethyl)-1,2,4-triazole-3-carboxamide and 1-(1-Ethoxyethyl)-1,2,4-triazole-5-carboxamide. A mixture of methyl 1,2,4-triazole-3-carboxylate (25.4 g, 0.20 mole), dimethylformamide (200 ml), bis(p-nitrophenyl) phosphate (0.20 g), and ethyl vinyl ether (80 ml) was stirred in a stoppered flask at 25¡ã for 120 hrs. The solvent was removed in vacuo and ethyl acetate (300 ml) was added to the residue. A small amount of insoluble material was removed by filtration and the filtrate was evaporated to a syrup. The crude product was treated at 25¡ã for 24 hours with methanol saturated with anhydrous ammonia (300 ml). The solvent was removed in vacuo and addition of ethanol (100 ml) to the residue gave a crystalline product (12.0 g). Recrystallization from ethanol provided 10.0 g (27percent) of pure 1-(1-ethoxyethyl)-1,2,4-triazole-3-carboxamide with mp 163¡ã-166¡ã. Nmr (dmso-d6) delta1.11 (t, 3, J=7Hz, CH3 –CH2 –), 1.70 (d, 3, J=6 Hz, CH3), 3.44 (m, 2, CH3 CH2 –) 5.80 (q, 1, J=6 Hz, C–H), 7.65 and 7.85 (2 S, 2, NH2) 8.90 (s, 1, H-5). Anal. Calcd for C7 H12 N4 O2: C, 45.64; H, 6.57; N, 30.42. Found: C, 45.48; H, 6.61; N, 30.54.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 1H-1,2,4-triazole-3-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; ICN Pharmaceuticals, Inc.; US3991078; (1976); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4928-88-5, name is Methyl 1H-1,2,4-triazole-3-carboxylate, A new synthetic method of this compound is introduced below., Formula: C4H5N3O2

EXAMPLE 4 A mixture of methyl 1,2,4-triazole-3-carboxylate (24.0 g, 0.19 mole) and beta-D-ribofuranosyl-1,2,3,5-tetraacetate (60.2 g, 0.19 mole) was melted and then 1.1 g of p-toluenesulfonic acid was added thereto. The reaction mixture was reacted for 5 hours, while maintaining the temperature of the reaction mixture at 95+-5¡ã C. And then, the reaction mixture was crystallized with 300.8 DA of methanol to give 60.0 g of 1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-1,2,4-triazole-3-carboxylic acid methyl ester (yield: 82percent).

The synthetic route of 4928-88-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Lee, Tai-Au; Park, Nam-Jin; Khoo, Ja-Heouk; Lee, Byung-Cheol; US2003/120064; (2003); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

4928-88-5, name is Methyl 1H-1,2,4-triazole-3-carboxylate, belongs to Triazoles compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of Methyl 1H-1,2,4-triazole-3-carboxylate

EXAMPLE 3 A mixture of methyl 1,2,4-triazole-3-carboxylate (26.4 g, 0.21 mole) and beta-D-ribofuranosyl-1,2,3,5-tetraacetate (60.2 g, 0.19 mole) was melted and then 1.1 g of p-toluenesulfonic acid was added thereto. The reaction mixture was reacted for 3 hours, while maintaining the temperature of the reaction mixture at 105+-5¡ã C. And then, the reaction mixture was crystallized with 300.8 ml of methanol to give 58.6 g of 1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-1,2,4-triazole-3-carboxylic acid methyl ester (yield: 80percent).

The synthetic route of 4928-88-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Lee, Tai-Au; Park, Nam-Jin; Khoo, Ja-Heouk; Lee, Byung-Cheol; US2003/120064; (2003); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthetic Route of 4928-88-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4928-88-5, name is Methyl 1H-1,2,4-triazole-3-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 16 A mixture of methyl 1,2,4-triazole-3-carboxylate (1.27 g, 0.01 mole) and beta-D-ribofuranosyl-1,2,3,5-tetraacetate (3.18 g, 0.01 mole) was melted and then 0.076 g of p-toluenesulfonic acid was added thereto. The reaction mixture was reacted for 3 hours, while maintaining the temperature of the reaction mixture at 95+-5¡ã C. And then, the reaction mixture was crystallized with 20 ml of isobutanol to give 2.92 g of 1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-1,2,4-triazole-3-carboxylic acid methyl ester (yield: 92percent).

The chemical industry reduces the impact on the environment during synthesis Methyl 1H-1,2,4-triazole-3-carboxylate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Lee, Tai-Au; Park, Nam-Jin; Khoo, Ja-Heouk; Lee, Byung-Cheol; US2003/120064; (2003); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Related Products of 4928-88-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4928-88-5 name is Methyl 1H-1,2,4-triazole-3-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 15 A mixture of methyl 1,2,4-triazole-3-carboxylate (1.27 g, 0.01 mole) and beta-D-ribofuranosyl-1,2,3,5-tetraacetate (3.18 g, 0.01 mole) was melted and then 0.076 g of p-toluenesulfonic acid was added thereto. The reaction mixture was reacted for 3 hours, while maintaining the temperature of the reaction mixture at 95+-5¡ã C. And then, the reaction mixture was crystallized with 20 ml of butanol to give 2.70 g of 1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-1,2,4-triazole-3-carboxylic acid methyl ester (yield: 85percent).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 1H-1,2,4-triazole-3-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; Lee, Tai-Au; Park, Nam-Jin; Khoo, Ja-Heouk; Lee, Byung-Cheol; US2003/120064; (2003); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Electric Literature of 4928-88-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4928-88-5, name is Methyl 1H-1,2,4-triazole-3-carboxylate belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 8 A mixture of methyl 1,2,4-triazole-3-carboxylate (26.4 g, 0.21 mole) and beta-D-ribofuranosyl-1,2,3,5-tetraacetate (60.2 g, 0.19 mole) was melted and then 1.1 g of p-toluenesulfonic acid was added thereto. The reaction mixture was reacted for 5 hours, while maintaining the temperature of the reaction mixture at 95+-5¡ã C. And then, the reaction mixture was crystallized with 180.5 ml of methanol to give 68.9 g of 1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-1,2,4-triazole-3-carboxylic acid methyl ester (yield: 95percent).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 1H-1,2,4-triazole-3-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Lee, Tai-Au; Park, Nam-Jin; Khoo, Ja-Heouk; Lee, Byung-Cheol; US2003/120064; (2003); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics