Category: 51039-49-7

New discoveries in chemical research and development in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 51039-49-7, name is 2-Phenyl-2H-1,2,3-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 51039-49-7

Step3. Synthesis of 2-(4-bromophenyl)-2H-1,2,3-triazole. [1.1.5c] 1.1.5c 1.1.5b (68 mg, 0.468 mmol) was dissolved in concentrated H2S04 (2 mL) and Br2 (0.024 mL, 0.468 mmol) was added, followed by Ag2S04 (175 mg, 0.56 mmol). After stirring at room temperature for 40 minutes, the reaction mixture was poured into water and extracted with ethyl acetate. The organic layer was dried (Na2S04) and concentrated to afford 1.1.5c (40 mg, 38 % yield) as an off white solid. LCMS (m/z) 225.9 [M+H]+ 1H NMR (400 MHz, CDCI3) 7.99 (d, J = 8.61 Hz, 2H), 7.83 (s, 2H), 7.62 (d, J = 8.61 Hz, 2H)

If you are hungry for even more, make sure to check my other article about 51039-49-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; FU, Jiping; KARUR, Subramanian; MADERA, Ann Marie; PECCHI, Sabina; SWEENEY, Zachary Kevin; TJANDRA, Meiliana; YIFRU, Aregahegn; WO2014/160649; (2014); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Some common heterocyclic compound, 51039-49-7, name is 2-Phenyl-2H-1,2,3-triazole, molecular formula is C8H7N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 51039-49-7

Step3. Synthesis of 2-(4-bromophenyl)-2H-1,2,3-triazole. [1.1.5c] 1.1.5c 1.1.5b (68 mg, 0.468 mmol) was dissolved in concentrated H2S04 (2 mL) and Br2 (0.024 mL, 0.468 mmol) was added, followed by Ag2S04 (175 mg, 0.56 mmol). After stirring at room temperature for 40 minutes, the reaction mixture was poured into water and extracted with ethyl acetate. The organic layer was dried (Na2S04) and concentrated to afford 1.1.5c (40 mg, 38 % yield) as an off white solid. LCMS (m/z) 225.9 [M+H]+ 1H NMR (400 MHz, CDCI3) 7.99 (d, J = 8.61 Hz, 2H), 7.83 (s, 2H), 7.62 (d, J = 8.61 Hz, 2H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 51039-49-7, its application will become more common.

Reference:
Patent; NOVARTIS AG; FU, Jiping; KARUR, Subramanian; MADERA, Ann Marie; PECCHI, Sabina; SWEENEY, Zachary Kevin; TJANDRA, Meiliana; YIFRU, Aregahegn; WO2014/160649; (2014); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics